AiPD: Autoinhibited Protein Database

Q86V25

Gene name	VASH2
Protein name	Tubulinyl-Tyr carboxypeptidase 2
Names	Vasohibin-2, Vasohibin-like protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79805
EC number	3.4.17.17: Metallocarboxypeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-63 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for Q86V25

Entry ID	Method	Resolution	Chain	Position	Source
6J4O	X-ray	230 A	A	46-296	PDB
6J4P	X-ray	160 A	A	46-296	PDB
6J4Q	X-ray	270 A	A/C/F/J	46-296	PDB
6J4S	X-ray	280 A	A	1-355	PDB
6J4V	X-ray	210 A	A	46-296	PDB
6QBY	X-ray	209 A	A/C	40-295	PDB
7ZCW	EM	360 A	C	1-355	PDB
AF-Q86V25-F1	Predicted				AlphaFoldDB

287 variants for Q86V25

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1246485508 CA344796931	3	G>R		No	ClinGen TOPMed gnomAD
rs1184804017 CA344796952	4	S>Y		No	ClinGen gnomAD
rs763067247 CA1386241	6	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	7	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1416099809 CA344797057	10	R>H		No	ClinGen TOPMed gnomAD
CA344797120 rs1411354969	12	P>L		No	ClinGen gnomAD
CA344797106 rs1363955409	12	P>S		No	ClinGen gnomAD
CA344797138 rs1359455128	13	H>L		No	ClinGen TOPMed
rs913842786 CA344797143	13	H>Q		No	ClinGen gnomAD
rs1226553627 CA344797210	17	A>T		No	ClinGen gnomAD
CA1386245 rs761657176	19	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1420960109 CA344797275	20	T>A		No	ClinGen TOPMed
rs1420960109 CA344797276	20	T>S		No	ClinGen TOPMed
CA344797287 rs1287233323	21	R>G		No	ClinGen TOPMed gnomAD
rs989450377 CA36881843	22	S>Y		No	ClinGen TOPMed
rs1253049156 CA344797318	23	R>Q		No	ClinGen TOPMed gnomAD
rs945281241 CA36881859	26	H>Y		No	ClinGen gnomAD
CA1386247 rs750333194	27	A>T		No	ClinGen ExAC gnomAD
CA344797376 rs1267022601	27	A>V		No	ClinGen gnomAD
rs1239270181 CA344797390	28	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1473132255 CA344797401	29	P>H		No	ClinGen gnomAD
CA344797398 rs1234545147	29	P>S		No	ClinGen Ensembl
CA344797425 rs1162739136	31	S>N		No	ClinGen gnomAD
rs765828817 CA1386249	32	L>F		No	ClinGen ExAC
rs1168972117 CA344797453	33	A>G		No	ClinGen TOPMed gnomAD
rs370044266 CA36881888	33	A>S		No	ClinGen ESP
rs574615632 CA36881892	34	T>N		No	ClinGen 1000Genomes
rs1183292809 CA344797462	34	T>S		No	ClinGen gnomAD
rs1336157877 CA344797485	36	G>R		No	ClinGen gnomAD
rs1336157877 CA344797489	36	G>W		No	ClinGen gnomAD
CA36881957 rs924925445	37	G>D		No	ClinGen TOPMed gnomAD
CA1386251 rs754645363	37	G>S		No	ClinGen ExAC TOPMed gnomAD
rs924925445 CA344797511	37	G>V		No	ClinGen TOPMed gnomAD
CA344797527 rs1228736371	39	E>K		No	ClinGen gnomAD
rs1275790750 CA344797539	39	E>V		No	ClinGen gnomAD
CA36881972 rs937777839	41	E>D		No	ClinGen Ensembl
rs1572052765 CA344797581	42	D>G		No	ClinGen Ensembl
rs1572052757 CA344797577	42	D>N		No	ClinGen Ensembl
CA36881978 rs759620375	43	K>E		No	ClinGen Ensembl
rs868203688 CA36881984	44	D>E		No	ClinGen gnomAD
CA344797615 rs1341968841	44	D>N		No	ClinGen gnomAD
CA344797628 rs1558138450	44	D>V		No	ClinGen Ensembl
CA344797641 rs1281255472	45	G>R		No	ClinGen TOPMed gnomAD
CA344797637 rs1281255472	45	G>S		No	ClinGen TOPMed gnomAD
rs765047470 CA1386254	46	G>R		No	ClinGen ExAC gnomAD
rs1558138465 CA344797681	47	V>G		No	ClinGen Ensembl
CA344797673 rs751957489	47	V>L		No	ClinGen ExAC gnomAD
rs751957489 CA1386255	47	V>M		No	ClinGen ExAC gnomAD
CA1386256 rs202035062	48	L>M		No	ClinGen ExAC TOPMed gnomAD
CA1386257 rs781735501	49	F>L		No	ClinGen ExAC TOPMed gnomAD
CA344797699 rs781735501	49	F>V		No	ClinGen ExAC TOPMed gnomAD
CA344797742 rs746388701	50	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA344797755 rs1356915024	51	V>I		No	ClinGen TOPMed
rs922109850 CA36881992	52	N>S		No	ClinGen TOPMed
CA344797789 rs1389306392	53	K>T		No	ClinGen gnomAD
rs756166915 CA1386259	54	S>R		No	ClinGen ExAC TOPMed gnomAD
CA344797896 rs1413885925	57	P>A		No	ClinGen gnomAD
rs1572052853 CA344797902	58	I>L		No	ClinGen Ensembl
CA344797971 rs1366818216	61	H>N		No	ClinGen TOPMed gnomAD
rs774571991 CA344797976	61	H>P		No	ClinGen ExAC TOPMed
rs774571991 CA1386263	61	H>R		No	ClinGen ExAC TOPMed
CA344797970 rs1366818216	61	H>Y		No	ClinGen TOPMed gnomAD
CA1386265 rs771886693 CA344798011	63	W>R		No	ClinGen ExAC gnomAD
rs561573614 CA1386266	64	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344798036 rs1324323224	64	E>Q		No	ClinGen TOPMed gnomAD
rs1471901051 CA344798064	65	R>L		No	ClinGen TOPMed
rs766379295 CA1386268	66	M>L		No	ClinGen ExAC TOPMed gnomAD
CA344798130 rs1261334755	68	M>T		No	ClinGen gnomAD
rs1200432708 CA344798124	68	M>V		No	ClinGen gnomAD
rs1466358524 CA344798165	69	H>Q		No	ClinGen gnomAD
rs776000020 CA1386269	70	V>L		No	ClinGen ExAC gnomAD
CA344798211 rs1247574595	72	K>M		No	ClinGen gnomAD
CA1386270 rs759173471	73	V>L		No	ClinGen ExAC gnomAD
rs1378030471 CA344798227	74	H>N		No	ClinGen gnomAD
CA1386271 rs764922504 CA344798258	76	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1048833699 CA36882038	76	K>T		No	ClinGen TOPMed
rs1558138599 CA344798263	77	G>E		No	ClinGen Ensembl
rs147838895 CA1386272 CA344798260	77	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs147838895 CA1386273	77	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA1386275 rs767792299	78	G>A		No	ClinGen ExAC gnomAD
TCGA novel	78	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767792299 CA1386274	78	G>V		No	ClinGen ExAC gnomAD
TCGA novel	79	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	79	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1376431162 CA344798286	79	E>V		No	ClinGen TOPMed
CA344798291 rs1457245685	80	M>V		No	ClinGen gnomAD
CA1386276 rs756578657	81	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	83	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344798332 rs1382256453	83	A>V		No	ClinGen gnomAD
COSM382997 rs1223426011 CA344798382	88	A>P	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs749272646 CA1386278	88	A>V		No	ClinGen ExAC TOPMed gnomAD
CA344798397 rs1401500214	89	F>L		No	ClinGen TOPMed
rs1173190569 CA344798417	91	A>T		No	ClinGen TOPMed
CA1386313 rs374073809	93	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs374073809 CA1386312	93	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs374073809 CA1386311	93	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs368019092 CA36890391	95	I>V		No	ClinGen ESP TOPMed gnomAD
CA1386315 rs765798613	96	P>H		No	ClinGen ExAC gnomAD
TCGA novel	97	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1249483645 CA344800367	97	Q>H		No	ClinGen gnomAD
rs1484213043 CA344800395	98	V>D		No	ClinGen gnomAD
CA344800482 rs1181886073	101	Y>D		No	ClinGen gnomAD
rs1181886073 CA344800479	101	Y>H		No	ClinGen gnomAD
rs1335390776 CA344800499	102	R>K		No	ClinGen TOPMed
CA36890396 rs956708184	102	R>S		No	ClinGen TOPMed
CA1386319 rs751836238	104	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1386318 rs777789606	104	S>P		No	ClinGen ExAC TOPMed gnomAD
CA344800529 rs751836238	104	S>W		No	ClinGen ExAC TOPMed gnomAD
CA36890410 rs546864186	105	M>T		No	ClinGen TOPMed
CA1386321 rs781108855	105	M>V		No	ClinGen ExAC gnomAD
rs745695023 COSM1232187 CA1386322 COSM1232188	106	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs748743761 CA1386325	107	I>M		No	ClinGen ExAC TOPMed gnomAD
CA344800561 rs1303466914	107	I>N		No	ClinGen gnomAD
CA36890454 rs138725158	109	D>A		No	ClinGen ESP TOPMed gnomAD
CA344800595 rs1425924285	110	W>*		No	ClinGen gnomAD
rs1351722049 CA344800590	110	W>G		No	ClinGen Ensembl
CA1386326 rs768248056	110	W>L		No	ClinGen ExAC gnomAD
rs1300027573 CA344800600	111	L>I		No	ClinGen gnomAD
CA344800614 rs1572061871	112	Q>P		No	ClinGen Ensembl
COSM532363 rs771662401 COSM532364 CA344800623	113	A>E	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1386328 rs146398288	113	A>T		No	ClinGen ESP ExAC gnomAD
rs771662401 COSM903629 CA1386329 COSM903628	113	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	115	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs189459502 CA1386331	118	M>L		No	ClinGen 1000Genomes ExAC gnomAD
rs142987440 CA1386332	118	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1213292733 CA344800868	125	H>P		No	ClinGen gnomAD
rs1446029797 CA344800866	125	H>Y		No	ClinGen gnomAD
rs1415480351 CA344800883	126	T>I		No	ClinGen TOPMed
rs749272047 CA1386343	129	Q>R		No	ClinGen ExAC gnomAD
rs981296919 CA36893515	135	K>R		No	ClinGen Ensembl
CA36893520 rs780891441	138	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs960671397 CA36893809	145	T>K		No	ClinGen TOPMed
rs1233513357 CA344802138	150	T>I		No	ClinGen gnomAD
rs1221181181 CA344802141	151	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs558983637 CA1386350	151	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775923575 CA1386351	153	S>A		No	ClinGen ExAC gnomAD
rs1277697895 CA344802226	158	C>R		No	ClinGen TOPMed
rs763490312 CA1386352	160	E>G		No	ClinGen ExAC gnomAD
rs1162658597 CA344802282	162	V>A		No	ClinGen gnomAD
rs1558145658 CA344802329	166	I>T		No	ClinGen Ensembl
rs1222932493 CA344804360	167	Y>*		No	ClinGen gnomAD
CA36898555 rs202039649	168	L>F		No	ClinGen Ensembl
rs1213769651 CA344804380	169	T>S		No	ClinGen TOPMed
TCGA novel	170	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1206013839 CA344804424	173	P>S		No	ClinGen gnomAD
rs1206013839 CA344804422	173	P>T		No	ClinGen gnomAD
rs199579781 CA1386372	175	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1207193213 CA344804455	176	E>K		No	ClinGen TOPMed
CA1386373 rs772304910	177	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1051024012 CA36898560	177	R>W		No	ClinGen TOPMed
COSM3418721 COSM3418720 CA36898607 rs890925192	186	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs753655168 CA1386377	188	G>A		No	ClinGen ExAC gnomAD
CA1386379 rs765153217	190	Y>H		No	ClinGen ExAC gnomAD
CA344804642 rs1246446084	192	H>N		No	ClinGen TOPMed gnomAD
CA344804640 rs1246446084	192	H>Y		No	ClinGen TOPMed gnomAD
rs1013655646 COSM903635 CA36898660 COSM903636	194	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs757854031 CA1386381	196	L>V		No	ClinGen ExAC TOPMed gnomAD
rs777239628 CA1386382	197	G>E		No	ClinGen ExAC TOPMed gnomAD
rs751105699 CA1386383	200	C>G		No	ClinGen ExAC gnomAD
CA1386384 rs185093740	201	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs749602409 CA1386386	203	R>C		No	ClinGen ExAC TOPMed gnomAD
rs150945050 CA1386387	203	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA344804717 rs1348837590	204	Y>D		No	ClinGen TOPMed gnomAD
rs1348837590 CA344804716	204	Y>H		No	ClinGen TOPMed gnomAD
rs1182805241 CA344804727	205	G>A		No	ClinGen TOPMed gnomAD
CA344804738 rs1484843582	207	L>S		No	ClinGen TOPMed
CA1386389 rs190097084	208	G>A		No	ClinGen 1000Genomes ExAC TOPMed
CA344804745 rs190097084	208	G>D		No	ClinGen 1000Genomes ExAC TOPMed
CA344804742 rs1292274306	208	G>S		No	ClinGen gnomAD
rs772746948 CA1386390	211	R>C		No	ClinGen ExAC gnomAD
rs1197260560 COSM425262 CA344804766 COSM425263	211	R>H	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA344804788 rs1164742031	214	E>D		No	ClinGen TOPMed gnomAD
rs1213409637 CA344804799	216	M>T		No	ClinGen TOPMed
CA1386393 rs771129048	217	D>E		No	ClinGen ExAC gnomAD
rs760897843 CA1386392	217	D>N		No	ClinGen ExAC gnomAD
rs759334108 CA1386395	223	R>Q		No	ClinGen ExAC gnomAD
CA1386394 rs776720732	223	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1412504172 CA344804849	224	T>A		No	ClinGen TOPMed
rs1558148402 CA344804853	224	T>I		No	ClinGen Ensembl
rs763227584 CA1386396	226	S>G		No	ClinGen ExAC TOPMed gnomAD
rs752585913 CA1386397	227	D>H		No	ClinGen ExAC gnomAD
rs1392000979 CA344804884	229	I>T		No	ClinGen TOPMed gnomAD
CA344804881 rs1376176462	229	I>V		No	ClinGen TOPMed gnomAD
CA344804893 rs1306444566	230	F>L		No	ClinGen gnomAD
CA344804895 rs1334171764	231	D>H		No	ClinGen gnomAD
rs1334171764 CA344804896	231	D>Y		No	ClinGen gnomAD
rs1457333432 CA344804941	237	K>E		No	ClinGen TOPMed gnomAD
CA344804945 rs1315450266	237	K>R		No	ClinGen gnomAD
rs1358390376 CA344804951	238	K>T	Variant assessed as Somatic; 0.0002772 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs751052622 CA1386400	243	V>I		No	ClinGen ExAC gnomAD
CA344805003 rs756768360	245	K>N		No	ClinGen ExAC gnomAD
rs780860487 CA1386403	247	K>E		No	ClinGen ExAC gnomAD
rs780860487 CA1386404	247	K>Q		No	ClinGen ExAC gnomAD
CA1386405 rs143295860	248	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1386406 rs779117080	248	I>T		No	ClinGen ExAC TOPMed gnomAD
CA344805045 rs140457516	251	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778439455 CA1386409	251	Y>C		No	ClinGen ExAC gnomAD
COSM1232189 rs547668925 COSM1232190 CA1386411	252	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1386414 rs767217848	254	H>Q		No	ClinGen ExAC gnomAD
CA1386412 rs776863243	254	H>Y		No	ClinGen ExAC
CA1386417 rs762791391	255	E>D		No	ClinGen ExAC TOPMed gnomAD
rs775256605 CA1386416	255	E>K		No	ClinGen ExAC TOPMed gnomAD
rs267598362 CA36898886	256	P>L		No	ClinGen Ensembl
CA1386419 rs372369361	256	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1386418 rs372369361	256	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1243433850 CA344805107	257	H>Y		No	ClinGen TOPMed gnomAD
CA1386420 rs761340891	258	S>N		No	ClinGen ExAC gnomAD
rs922948611 CA36898894	259	F>S		No	ClinGen Ensembl
CA1386423 rs138495697	262	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs369702207 CA1386424	262	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA344805186 rs1203762738	263	E>G		No	ClinGen gnomAD
rs1459722563 CA344805199	264	W>*		No	ClinGen gnomAD
CA344805231 rs1180447061	266	Q>R		No	ClinGen gnomAD
CA344805250 rs914105883	268	V>F		No	ClinGen TOPMed gnomAD
rs914105883 CA36898916	268	V>I		No	ClinGen TOPMed gnomAD
rs1470973480 CA344805277	270	N>S		No	ClinGen gnomAD
rs372322708 CA1386429	271	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1386432 rs769890903	272	S>T		No	ClinGen ExAC gnomAD
CA344805331 rs1356243158	274	M>I		No	ClinGen TOPMed
rs1442799079 CA344805327	274	M>T		No	ClinGen TOPMed
rs200712541 CA36898924	275	L>P		No	ClinGen Ensembl
CA344805383 rs376961593 CA1386433	279	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1381454131 CA344805387	279	I>T		No	ClinGen gnomAD
rs376961593 CA1386434	279	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1572073005 CA344805440	284	E>Q		No	ClinGen Ensembl
CA1386435 rs768463996	287	A>V		No	ClinGen ExAC gnomAD
CA344805489 rs1223543072	290	M>I		No	ClinGen gnomAD
CA1386436 rs149392900	290	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA36898934 rs149392900	290	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA36899715 rs1019948322	294	I>V		No	ClinGen Ensembl
CA344806373 rs1326867694	295	L>P		No	ClinGen TOPMed
rs762248062 CA1386464	296	K>N		No	ClinGen ExAC gnomAD
CA344806429 rs1443955639	297	P>R		No	ClinGen gnomAD
rs767841990 CA1386465	297	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1338221147 CA344806437	298	A>P		No	ClinGen gnomAD
CA344806440 rs1383113563	298	A>V		No	ClinGen gnomAD
CA344806456 rs1247116760	299	S>N		No	ClinGen gnomAD
TCGA novel	302	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1354826794 CA344806516	302	S>Y		No	ClinGen gnomAD
CA1386467 rs533306170	303	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780081188 CA1386468	303	P>L	Variant assessed as Somatic; 0.0003235 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755180737 CA1386470	305	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs1413492029 CA344806562	306	V>M		No	ClinGen TOPMed
CA344806626 rs1182716628	309	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1386472 COSM1232185 rs779122598 COSM1232186	309	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs747833049 CA36899779	312	S>F		No	ClinGen ExAC TOPMed gnomAD
rs747833049 CA1386473	312	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA1386474 rs771934608	313	L>V		No	ClinGen ExAC TOPMed gnomAD
CA1386475 rs777521640	314	S>F		No	ClinGen ExAC gnomAD
TCGA novel	314	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs908332955 CA36899792	319	Q>E		No	ClinGen TOPMed gnomAD
CA344806798 rs1558149213	320	A>T		No	ClinGen Ensembl
rs147347763 CA1386479	322	P>L		No	ClinGen ESP ExAC gnomAD
rs759171226 CA344806841	323	P>A		No	ClinGen ExAC TOPMed gnomAD
rs769510234 CA1386481	323	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759171226 CA1386480	323	P>T		No	ClinGen ExAC TOPMed gnomAD
CA1386483 rs762040777	324	R>G		No	ClinGen ExAC gnomAD
CA344806856 rs1426841019	324	R>K		No	ClinGen gnomAD
TCGA novel	325	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767904683 CA1386484	325	R>G		No	ClinGen ExAC gnomAD
rs549406503 CA36899866	326	L>F		No	ClinGen gnomAD
CA1386485 rs199687294	327	G>S		No	ClinGen ExAC gnomAD
rs1254353034 CA344806921	327	G>V		No	ClinGen TOPMed gnomAD
CA1386487 rs35976699	328	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145299792 CA1386486	328	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA344806935 rs1476830659	329	R>*		No	ClinGen gnomAD
rs60032955 CA1386488	329	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1232191 rs907908245 CA36899898 COSM1232192	330	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs755056065 CA1386489	332	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA344809147 rs1337726294	333	P>T		No	ClinGen TOPMed gnomAD
rs745819910 CA1386516	334	A>V		No	ClinGen ExAC gnomAD
CA344809160 rs1308246195	335	L>R		No	ClinGen gnomAD
rs544857449 CA1386517	336	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA344809196 rs1490291716	340	V>A		No	ClinGen Ensembl
rs748810843 CA1386519	341	A>T		No	ClinGen ExAC gnomAD
CA36907059 rs376941663	344	S>G		No	ClinGen Ensembl
rs747266193 CA344809223	345	T>P		No	ClinGen gnomAD
rs747266193 CA36907063	345	T>S		No	ClinGen gnomAD
CA344809239 rs542871161	347	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1378104731 CA344809242	348	E>K		No	ClinGen gnomAD
CA344809251 rs1295563328	349	V>M		No	ClinGen TOPMed
rs561175067 CA1386523	350	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1386524 rs777031301	351	Y>H		No	ClinGen ExAC gnomAD
rs1386384700 CA344809269	352	Q>*		No	ClinGen TOPMed gnomAD
rs1386384700 CA344809268	352	Q>E		No	ClinGen TOPMed gnomAD
CA1386525 rs760003665	352	Q>R		No	ClinGen ExAC gnomAD
CA1386526 rs528044734	354	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD

No associated diseases with Q86V25

No regional properties for Q86V25

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q86V25

Functions

		Description
EC Number	3.4.17.17	Metallocarboxypeptidases
Subcellular Localization	Cytoplasm Secreted Cytoplasm, cytoskeleton	Mainly localizes in the cytoplasm (PubMed:19204325) Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312) Associates with microtubules (PubMed:31235911)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

4 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
metallocarboxypeptidase activity	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
tubulin-tyrosine carboxypeptidase	Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-

8 GO annotations of biological process

Name	Definition
axon development	The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
cell-cell fusion	A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.
labyrinthine layer blood vessel development	The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of angiogenesis	Any process that modulates the frequency, rate or extent of angiogenesis.
syncytium formation by plasma membrane fusion	The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MTGSAADTHR	CPHPKGAKGT	RSRSSHARPV	SLATSGGSEE	EDKDGGVLFH	VNKSGFPIDS
70	80	90	100	110	120
HTWERMWMHV	AKVHPKGGEM	VGAIRNAAFL	AKPSIPQVPN	YRLSMTIPDW	LQAIQNYMKT
130	140	150	160	170	180
LQYNHTGTQF	FEIRKMRPLS	GLMETAKEMT	RESLPIKCLE	AVILGIYLTN	GQPSIERFPI
190	200	210	220	230	240
SFKTYFSGNY	FHHVVLGIYC	NGRYGSLGMS	RRAELMDKPL	TFRTLSDLIF	DFEDSYKKYL
250	260	270	280	290	300
HTVKKVKIGL	YVPHEPHSFQ	PIEWKQLVLN	VSKMLRADIR	KELEKYARDM	RMKILKPASA
310	320	330	340	350
HSPTQVRSRG	KSLSPRRRQA	SPPRRLGRRE	KSPALPEKKV	ADLSTLNEVG	YQIRI