Q86L04

PR
Gene name
trap1 (DDB_G0276947)
Protein name
TNF receptor-associated protein 1 homolog, mitochondrial
Names
TNFR-associated protein 1 homolog, Trap1 homolog
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0276947
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86L04

Entry ID Method Resolution Chain Position Source
AF-Q86L04-F1 Predicted AlphaFoldDB

No variants for Q86L04

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q86L04

No associated diseases with Q86L04

1 regional properties for Q86L04

Type Name Position InterPro Accession
domain Heat shock protein Hsp90, N-terminal 99 - 301 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cell cortex
  • Cytoplasm, cytoskeleton
  • Mitochondrion
  • Spore, perispore
  • Nucleus, nucleolus
  • Localizes to the cortical actin cytoskeleton
  • Translocates to the mitochondrion during the prestarvation response and in response to differentiation
  • In prespore cells, colocalizes with grp94 in the prespore-specific vacuole
  • Found in the outermost layer of spore cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
spore wall The specialized envelope lying outside the cell membrane of a spore.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
unfolded protein binding Binding to an unfolded protein.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRTLSKVIL NSGKNNLLKS SNLLNSNLLK ATTTNIIGIK TINNNNNVNS IIGFKSLNKR
70 80 90 100 110 120
YFTSNTPKVE EEDDEIAPDE AIKAEEKIKE TERVIGLSEK LSFQTETQKI LHIVAESLYT
130 140 150 160 170 180
EKEVFIRELI SNASDAIEKV RHTQLTNASM IEDASIPFEI KISTDEDNKT LIIQDSGIGM
190 200 210 220 230 240
TKDEMIKNLG KIGYSGSSDF IKKLGENPDK ASIIGQFGVG FYSCFMVGHT IKIYTKSATP
250 260 270 280 290 300
GSKGYLWESD GTGSYSITEA EGVSRGTKII IHLKPSSYEY SKKSIVENII KKYSNFVGFP
310 320 330 340 350 360
IALNGTTVNT IKPLWTLNKN AISEEEHKEF YQFLSKSYDT PSYRVHFSTD TPLSIRSIFY
370 380 390 400 410 420
IPSQHMEKYG MGKMEPGVSL FSRKVLIQQK ANGILPEWMR FVRGVVDSED IPLNVSREHL
430 440 450 460 470 480
QDNGLIQRIS SVLVKRILKH LNDEAKSDPE KFNVFMTEFG GFFKEGIITD FKWKDEISKL
490 500 510 520 530 540
LRFESSNGST ASKTDAVSLE QYVSRMKPEQ KNIYFLSVPN RAVGLSSPYY EPFQLKDIEV
550 560 570 580 590 600
IFLYNAVDEF VLTNVGHFGD KKIVSVESKE AEEFLATNQD KKTETLSQDE IDKFLSWVST
610 620 630 640 650 660
VASDKVTQAK STTRSISSPA IIIDHESANF RRMLKMVEPG KQHETPKQVV EFNMNHPIIL
670 680 690 700 710
KLVQQTESNP TIAKLVIDQV VDNAFVSAGL IEDNREMIPR INQLLDSLLT K