Q86JA1

PR
Gene name
psmC2 (DDB_G0276917)
Protein name
26S proteasome regulatory subunit 7
Names
26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0276917
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86JA1

Entry ID Method Resolution Chain Position Source
AF-Q86JA1-F1 Predicted AlphaFoldDB

No variants for Q86JA1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q86JA1

No associated diseases with Q86JA1

4 regional properties for Q86JA1

Type Name Position InterPro Accession
domain AAA+ ATPase domain 203 - 342 IPR003593
domain ATPase, AAA-type, core 207 - 339 IPR003959
conserved_site ATPase, AAA-type, conserved site 310 - 328 IPR003960
domain AAA ATPase, AAA+ lid domain 362 - 406 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

2 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVNKEDVEDE LLNETAPVAL DEGDIALLKS YGVGPYSKSI RILEEDIKKM TSKVNELCGI
70 80 90 100 110 120
KESDTGIGPP SQWDLVVDKT SAHEEPPLQV ARCTKIIDVG KPNAKYIITV KQIAKFVVAL
130 140 150 160 170 180
GDKLSPTDVE EGIRVGVDRN KYQIQIPLPP KIDASVTMMQ VEEKPDITYK DVGGCKEQIE
190 200 210 220 230 240
KLREVVEMPL LHPEKFVNLG IDPPKGVLMY GPPGTGKTLC ARAVANRTDA AFVRVIGSEL
250 260 270 280 290 300
VQKYVGEGAR MVRDLFQMAR SKKACIIFFD EVDAIGGARF DDGAGGDNEV QRTMLELINQ
310 320 330 340 350 360
LDGFDPRGNI KVLMATNRPD TLDPALLRPG RLDRKVEFGL PDLEGRAHIF TIHAKTMSCA
370 380 390 400 410 420
RDIRFELLAR LCPNSTGADI RSVCTEAGMF AIRARRKVVS EKDFLEAIDK VIKSYAKFSA
TSRYMHYN