Q86AX3

PR
Gene name
uroc1 (DDB_G0277727)
Protein name
Probable urocanate hydratase
Names
Urocanase, Imidazolonepropionate hydrolase
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0277727
EC number
4.2.1.49: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86AX3

Entry ID Method Resolution Chain Position Source
AF-Q86AX3-F1 Predicted AlphaFoldDB

No variants for Q86AX3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q86AX3

No associated diseases with Q86AX3

3 regional properties for Q86AX3

Type Name Position InterPro Accession
domain Urocanase, Rossmann-like domain 216 - 434 IPR035085
domain Urocanase, N-terminal domain 87 - 213 IPR035400
domain Urocanase, C-terminal domain 437 - 645 IPR035401

Functions

Description
EC Number 4.2.1.49 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
urocanate hydratase activity Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O.

3 GO annotations of biological process

Name Definition
histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidine catabolic process to glutamate and formamide The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide.
histidine catabolic process to glutamate and formate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKDLLSSLSK GIPFEPLPEH PGLDSTVPHA PGRPINLTLN EKKLAIKNSL RYFPNSLHSI
70 80 90 100 110 120
LANEFLEELN KYGHIYMYRF RPTHYEMKAY PIEEYPAKSR QAASIMLMIM NNLDREVAQF
130 140 150 160 170 180
PNELVTYGGN GSVFQNWAQY HLTMKYLSEM TDQQTLTMYS GHPMGLFPSN ESSPRVIVTN
190 200 210 220 230 240
GMVIPNYSSH KDYERMYAQG VTQYGQMTAG SYCYIGPQGI VHGTTITLLN AGRKYLGVES
250 260 270 280 290 300
LIGKVFVSSG LGGMSGAQTK AAYICGAICI VAEVSPAAVK KRHAQNWVME VYSDLNELFA
310 320 330 340 350 360
RGSCSKEKKP LSIAYQGNVV TLWEKLVEEK DITVDLGSDQ TSLHNPFNGG YYPVQCSFEE
370 380 390 400 410 420
SNRLMVQEPT KFKEMVQETL RRHTTAINAL SARGMKFWDY GNSFLLEASR AKADIIKPGT
430 440 450 460 470 480
DGKEFIYPSY VQDIMGDIFS LGFGPFRWVC TSGNPKDLEI TDRIAKELIE KLRSQPGVPK
490 500 510 520 530 540
NVQQQFNDNH LWISQAGEHK LVVGSQARIL YSDCIGRSEL AVAFNKAVAD GTLSAPVVIS
550 560 570 580 590 600
RDHHDVSGTD APWRETSNIK DGSQFCADMA IHNVIGDSFR GATWVAIHNG GGTGFGEAIN
610 620 630 640 650 660
GGFGLYLCGS KLQEEKARMM LNWDVNNGIA RRSWSYNDNA ENTIKRAMEL DPSLKVTIPN
670
HTSDDLINSL NF