Q86AS6

PR
Gene name
hisS (DDB_G0274159)
Protein name
Histidine--tRNA ligase, cytoplasmic
Names
Histidyl-tRNA synthetase, HisRS
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0274159
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86AS6

Entry ID Method Resolution Chain Position Source
AF-Q86AS6-F1 Predicted AlphaFoldDB

No variants for Q86AS6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q86AS6

No associated diseases with Q86AS6

4 regional properties for Q86AS6

Type Name Position InterPro Accession
domain Anticodon-binding 384 - 474 IPR004154
domain Aminoacyl-tRNA synthetase, class II 44 - 380 IPR006195
domain Histidyl-anticodon-binding 382 - 473 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 44 - 368 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

2 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEPVVDNVT NKVEKMEVKE KTSAPPKEKK EKKSNKVQLK TPKGTQDYNP RQMTIREQVF
70 80 90 100 110 120
DGIKQVFKRH GAVTIETPVF ELKETLTGKY GEDSKLIYDL QDQGGEICSL RYDLTVPFAR
130 140 150 160 170 180
YVAMNGVLNI KRYHIARVYR RDNPIMTKGR FREFYQCDFD IAGTYDLMVP DAECLVMICE
190 200 210 220 230 240
ILEQVKVGDF QIKLNHRKLL DAIFAICGVP ADKFRAICSA VDKLDKSPWE EVRKEMVEVK
250 260 270 280 290 300
ALDGAVADKI EKFVSLKDEP IKLLQHLRAT GMCDGNKDAT EALSQLETLF GYLECFGVTQ
310 320 330 340 350 360
HILFDLSLAR GLDYYTGIIY EAVLTGQDRV GSIAAGGRYD GLVGMYGKKD VPAVGFSIGI
370 380 390 400 410 420
ERIFTILEDE YKKENKKIRE NATQVFVVQM EKDLIKERLA IVSELWKAGI NAEFSYKVNP
430 440 450 460 470 480
KLPAQLNTAD ESNIPLIIII GKSEVETNSL SVKTMHDRKQ VSIERSNFTV KIKEILSTIP
K