Q869V1

PR
Gene name
nramp1 (nramp, slc11a1, DDB_G0276973)
Protein name
Metal transporter nramp1 homolog
Names
Natural resistance-associated membrane protein 1
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0276973
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q869V1

Entry ID Method Resolution Chain Position Source
AF-Q869V1-F1 Predicted AlphaFoldDB

No variants for Q869V1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q869V1

No associated diseases with Q869V1

5 regional properties for Q869V1

Type Name Position InterPro Accession
repeat Pumilio RNA-binding repeat 114 - 149 IPR001313-1
repeat Pumilio RNA-binding repeat 150 - 187 IPR001313-2
repeat Pumilio RNA-binding repeat 355 - 390 IPR001313-3
repeat Pumilio RNA-binding repeat 538 - 575 IPR001313-4
repeat Pumilio RNA-binding repeat 576 - 613 IPR001313-5

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Located at vesicles of variable size, which are distributed all over the cytoplasm, in part clustered at a perinuclear site
  • Several tiny vesicles travel rapidly outward from and towards the perinuclear cluster
  • These vesicles are part of the endo- and phagolysosomal pathway
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
macropinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
phagolysosome A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

4 GO annotations of molecular function

Name Definition
cadmium ion transmembrane transporter activity Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.
ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
iron ion transmembrane transporter activity Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
manganese ion transmembrane transporter activity Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

7 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
iron ion export across plasma membrane The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region.
iron ion transmembrane transport A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
manganese ion transport The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTPRIESEES APLVNKNNNN NNDNNNNNNV DEENPLIIES GIPIEDLEQK NKPYLIKVPN
70 80 90 100 110 120
IDKPDSKWIN FKTLWAFTGP GFLMSIAYLD PGNLESDIQA GAMAGYQLLW VLFWSTVIGF
130 140 150 160 170 180
WLQMLASRLG VVTGKHLAEH CREQYPKTPR LLLWLMTELA IIGSDIQEVI GTAIALQILS
190 200 210 220 230 240
NGHIPLWAGV LFTAADTFTF LFLEKYGIRK LEAFFCSLIA IMAISFGVEY IISKPDQIEV
250 260 270 280 290 300
VKGVFIPLCS QNNISQAVGI LGAVVMPHNI YLHSALVQSR EIDRKSETQV KIANKYNRLE
310 320 330 340 350 360
SAFALIISFI INLLLVSVFA KGFYGETTEI GLSSAADFLM DKYGKVAKYI WAIGLFSAGQ
370 380 390 400 410 420
CSTMTGTYSG QFVMEGFLKL KIAPWKRLLI TRCTAIVPAM VVAILSTSHL DSLDQWLNIL
430 440 450 460 470 480
QSIQLPFAVV PVLLFTSSEK IMGSKFKNHW LNNQFVRFLS LLIIAINIYL IITFSMQISE
490 500 510 520 530
SAWMISIVSI SFFFYFIFIV YLSMGQENFN SMTKKIKNLF NNNSNQTYNN INY