Q869Q3

PR
Gene name
napA (nap1, DDB_G0274519)
Protein name
Nck-associated protein 1 homolog
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0274519
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

287-361 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q869Q3

Entry ID Method Resolution Chain Position Source
AF-Q869Q3-F1 Predicted AlphaFoldDB

No variants for Q869Q3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q869Q3

No associated diseases with Q869Q3

No regional properties for Q869Q3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q869Q3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell leading edge The area of a motile cell closest to the direction of movement.
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
filopodium tip The end of a filopodium distal to the body of the cell.
pseudopodium A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
SCAR complex A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

15 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized.
cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
cell-substrate adhesion The attachment of a cell to the underlying substrate via adhesion molecules.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
polyphosphate-mediated signaling Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal.
positive phototaxis The directed movement of a cell or organism towards a source of light.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.
regulation of actin polymerization or depolymerization Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
ruffle assembly The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAHTNLPEKF QVVIENGENI LQRVYNTYKL FQNNKVKPSF FNDEKISKIL KNLIAKYPEL
70 80 90 100 110 120
PENNDKSITG FDLLTSRAKQ HLEELEDHYY TITDAYDWKE ASFILMQEIS SNTVSINFNN
130 140 150 160 170 180
NIQLCSKFLD VLVLYGKINY LVSLIPDKKI ITAVYAKLFL YTRSASEPTF SKMGRWINDI
190 200 210 220 230 240
EQPFKKIQEE FRVLNDAVGH ALSSFELTYA KRRVITQLRK DGALNLILKP EDIARPVQDS
250 260 270 280 290 300
YRIELAYAGR IQQWILFGYL FAPGTLSTPQ SIELLRFTLS ECFYLSVFKD ISISIHNEFN
310 320 330 340 350 360
TLFKNYKSKT INLQKQKKII KDAAQASTQE APRKHAERRV YIRQELEAMW NLFRDKPCLL
370 380 390 400 410 420
APKINVLLAA LSMAKEEIFW YFRHTDVIPP EKVKKFYNKQ NEVREKRISS LLSLVDHLVQ
430 440 450 460 470 480
LVHTHKKMIQ NYYLEYISGA DILGLQKVIT PQLLQNAGSI VTQAVNTIVN ELKSLNANGQ
490 500 510 520 530 540
DYSFEGFRAN WMRLGYLLQS NSCPLKESES KQITSRLNLI YTHSKNVDCL DQLLDEYGNM
550 560 570 580 590 600
TQLWSYKEPL FHSFDAAIVD MTCDQPSHSM IYLKLLSQFP NHVANQFYPE EKELIGKECV
610 620 630 640 650 660
ELANSCLTKI TNRIVSIMAN TIASTFLSDE QQLADVNAAF PLLQKKKDWK PPKDFVPPIE
670 680 690 700 710 720
PASESQFRNR ANLEQLRSEE KNAFQLCTAL NEFLDITIYD HIFVPREFLR EKLGSALKQY
730 740 750 760 770 780
MRQSIQPPAP TSSSSQIDIN ITRLSTYESQ LRVFIGVLIL VENHVDIDIG DLIRETILTE
790 800 810 820 830 840
FYAKALGKSG RVDWFPEGEI EMNELTLHSI TSYYVDLVSK KLNTPGVVFS PVKLGFISKA
850 860 870 880 890 900
GTPFRAEEHA DLTEMRALCD LVGPYGIKVI EREILRFILT TTTSMKEILS LNAANLEEFA
910 920 930 940 950 960
SNYYKPKAME LLKKFKTTDL DLIVTKSIAI GNALHLRSMI RESMKDVITD NFPYINNAVA
970 980 990 1000 1010 1020
NAFDQYNRNT FMFPDFLGVD TLALDSGLNV GIADQYLKVI LRKVSSEADK RIWELLPVMF
1030 1040 1050 1060 1070 1080
SLTFYGNIWK ETQYKATIDA HSNNVHVLSK TIIDLLIAFG AINSTTGNEA ELFQSFKRFL
1090 1100 1110 1120 1130 1140
EISSVNILRM FKGKQGEKFV PNEIQSVIIF LDKFTQQCPL LSKDSLEQYI PYSLIRNMYK
1150
DLYEHKNLQK QQSETSEQNF