Q867B5
PR
Gene name |
RAG1 |
Protein name |
V(D)J recombination-activating protein 1 |
Names |
CXC-R3, CXCR-3, Interferon-inducible protein 10 receptor, IP-10 receptor, RAG-1 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:397506 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q867B5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q867B5-F1 | Predicted | AlphaFoldDB |
No variants for Q867B5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q867B5 | |||||
No associated diseases with Q867B5
5 regional properties for Q867B5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, RING-type | 293 - 332 | IPR001841 |
| conserved_site | Zinc finger, RING-type, conserved site | 308 - 317 | IPR017907 |
| domain | V(D)J recombination-activating protein 1, Zinc finger | 354 - 383 | IPR019485 |
| domain | RAG nonamer-binding domain | 392 - 459 | IPR023336 |
| domain | RAG1 importin-binding | 12 - 291 | IPR035714 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| metal ion binding | Binding to a metal ion. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell differentiation | The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. |
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| histone monoubiquitination | The modification of histones by addition of a single ubiquitin group. |
| pre-B cell allelic exclusion | Expression of a single heavy chain allele during pre-B cell differentiation. |
| protein autoubiquitination | The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. |
| T cell differentiation in thymus | The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. |
| V(D)J recombination | The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVSLPPTLG | LSSAPDEIQH | PHIKFSEWKF | KLFRVRSFEK | APEKAQTEKQ | DSSEGKPSLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSPAVLDKPG | GQKSALPQPA | FKPHPKFLKE | SHEDGKARDK | AIHQANLRRL | CRICGNSFNT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGHKRRYPVH | GPVDGKTQVL | LRKKEKRATS | WPDLIAKVFR | IDVKADVDSI | HPTEFCHNCW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SFMHRKFSST | PCEVYSPRNA | AMEWHPHTLN | CDICHIARRG | LKRKSQQPNM | QLSKKLKTVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DRARQARQRK | RRAQARISSK | ELMKKIANCG | QIHLSPKLLA | VDFPAHFVKS | ISCQICEHIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADPVETSCKH | VFCRICILRC | LKVMGSSCPS | CHYPCFPTDL | ESPVKSFLSI | LNTLMVKCPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KECNEEISLE | KYNHHISSHK | ESKETFVHIN | KGGRPRQHLL | SLTRRAQKHR | LRELKLQVKA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FADKEEGGDV | KSVCLTLFLL | VLRARNEHRQ | ADELEAIMRG | QGSGLQPAVC | LAIRVNTFLS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CSQYHKMYRT | VKAITGRQIF | QPLHALRNAE | KVLLPGYHPF | EWQPPLKNVS | SSTDVGIIDG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSGLSSSVDD | YPVDTIAKRF | RYDSALVSAL | MDMEEDILEG | MRAQDLDDYL | NGPFTVVVKE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SCDGMGDVSE | KHGSGPVVPE | KAVRFSFTVM | KITIAHGSQN | VKVFEEAKPN | SELCCKPLCL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MLADESDHET | LTAILSPLIA | EREAMKSSQL | MLEMGGILRT | FKFIFRGTGY | DEKLVREVEG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LEASGSVYIC | TLCDATRLEA | SQNLVFHSIT | RSHAENLERY | EVWRSNPYHE | TVDELRDRVK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GVSAKPFIET | VPSIDALHCD | IGNAAEFYKI | FQLEIGEAYK | NPHASKEERK | RWQATLDKHL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RKKMNLKPIM | RMNGNFARKL | MTKETVEAVC | ELIPSEERHE | ALRELMDLYL | KMKPVWRSSC |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PAKECPESLC | QYSFNSQRFA | ELLSTKFKYR | YEGKITNYFH | KTLAHVPEII | ERDGSIGAWA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SEGNESGNKL | FRRFRKMNAR | QSKYYEMEDV | LKHHWLYTSK | YLQKFMNAHK | AFKNSGFTIN |
| 1030 | 1040 | ||||
| LQRSSGDTLD | LENSPESQDL | MEF |