Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q84WU9

Entry ID Method Resolution Chain Position Source
AF-Q84WU9-F1 Predicted AlphaFoldDB

63 variants for Q84WU9

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_23022643_C_T 10 D>N No 1000Genomes
ENSVATH00738187 11 P>A No 1000Genomes
tmp_5_23022631_G_A 14 R>C No 1000Genomes
tmp_5_23022630_C_T 14 R>H No 1000Genomes
ENSVATH14636481 18 L>I No 1000Genomes
tmp_5_23022607_C_A 22 V>F No 1000Genomes
tmp_5_23022493_G_T 31 P>T No 1000Genomes
ENSVATH00738183 38 V>I No 1000Genomes
tmp_5_23022464_C_A 40 Q>H No 1000Genomes
ENSVATH07436402 41 F>I No 1000Genomes
tmp_5_23022412_C_T 58 G>S No 1000Genomes
tmp_5_23022402_T_G 61 Q>P No 1000Genomes
tmp_5_23022396_G_T 63 P>Q No 1000Genomes
ENSVATH12814747 77 P>T No 1000Genomes
ENSVATH07436401 83 T>S No 1000Genomes
ENSVATH07436400 87 A>S No 1000Genomes
ENSVATH12814745 99 V>I No 1000Genomes
ENSVATH00738181 100 C>S No 1000Genomes
ENSVATH07436399 111 K>E No 1000Genomes
ENSVATH07436398 113 S>T No 1000Genomes
ENSVATH07436395 119 V>I No 1000Genomes
ENSVATH07436394 134 K>I No 1000Genomes
tmp_5_23022105_G_C 137 Q>E No 1000Genomes
tmp_5_23021926_G_C 167 N>K No 1000Genomes
ENSVATH12814732 172 S>F No 1000Genomes
ENSVATH12814731 181 S>F No 1000Genomes
tmp_5_23021882_G_A 182 S>F No 1000Genomes
tmp_5_23021706_A_T 209 Y>N No 1000Genomes
ENSVATH07436392 212 E>D No 1000Genomes
ENSVATH07436391 220 T>I No 1000Genomes
tmp_5_23021633_T_A 233 N>I No 1000Genomes
tmp_5_23021316_G_C 249 S>C No 1000Genomes
tmp_5_23021310_A_T 251 M>K No 1000Genomes
tmp_5_23021307_G_A 252 S>L No 1000Genomes
tmp_5_23021286_T_C 259 K>R No 1000Genomes
ENSVATH00738180 261 P>S No 1000Genomes
ENSVATH07436385 271 Q>L No 1000Genomes
tmp_5_23021220_G_C 281 P>R No 1000Genomes
ENSVATH14636475 311 K>Q No 1000Genomes
tmp_5_23021130_T_C 311 K>R No 1000Genomes
tmp_5_23021103_C_T 320 R>H No 1000Genomes
ENSVATH07436383 333 R>I No 1000Genomes
tmp_5_23021063_T_G 333 R>S No 1000Genomes
ENSVATH14636473 361 E>G No 1000Genomes
ENSVATH14636474 361 E>K No 1000Genomes
ENSVATH07436382 367 S>G No 1000Genomes
ENSVATH14636472 368 I>K No 1000Genomes
tmp_5_23020941_G_T 374 S>Y No 1000Genomes
tmp_5_23020827_T_A 382 E>D No 1000Genomes
ENSVATH14636471 391 S>N No 1000Genomes
tmp_5_23020785_T_A 396 L>F No 1000Genomes
ENSVATH07436381 398 V>A No 1000Genomes
tmp_5_23020730_C_T 415 E>K No 1000Genomes
ENSVATH00738179 445 N>T No 1000Genomes
tmp_5_23020416_C_T 494 A>T No 1000Genomes
tmp_5_23020207_C_G 534 G>R No 1000Genomes
ENSVATH00738177 541 L>W No 1000Genomes
tmp_5_23019847_C_A 565 R>M No 1000Genomes
tmp_5_23019812_C_A 577 E>* No 1000Genomes
tmp_5_23019811_T_A 577 E>V No 1000Genomes
ENSVATH12814698 581 L>R No 1000Genomes
tmp_5_23019791_C_A 584 D>Y No 1000Genomes
ENSVATH03441470 589 F>Y No 1000Genomes

No associated diseases with Q84WU9

4 regional properties for Q84WU9

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 303 - 331 IPR000571-1
domain Zinc finger, CCCH-type 335 - 363 IPR000571-2
domain Cwf19-like protein, C-terminal domain-2 505 - 593 IPR006767
domain Cwf19-like, C-terminal domain-1 372 - 490 IPR006768

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding Binding to a metal ion.
RNA lariat debranching enzyme activator activity Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide.

1 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O16216 F17A9.2 CWF19-like protein 1 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MAPRILLCGD PLGRLNQLFK RVQSVSKSAG PFDALICVGQ FFPDSPEILD EFLDYVEGRA
70 80 90 100 110 120
QVPIPTYFTG DYGVVAPKIL STTSKKAENQ GFKMDGLEVC HNLFWLRGSG KFSLHGLSVA
130 140 150 160 170 180
YLSGRQSSES QFGKYSQDDV DALRALAEEP GGVDLFLTNE WPAGVTNRAA VSDIPVGISD
190 200 210 220 230 240
SSCSDSTVSE LVMEVKPRYH IAGSMGVFYA REPYLNAEST HVTRFIGLAQ VGNKNKQKFL
250 260 270 280 290 300
HALSPTPTST MSPAELSAKP PKTTLWPYNL QDGAAESKKR PNDSDSDSQY WRYDVPKRQK
310 320 330 340 350 360
SGSQGEKLCF KFVCSGSCPR GEDCHFQHNA EAREQCRRGV CLDLIIKGKC EKGPECSYKH
370 380 390 400 410 420
EFQDESSIQR KPRSENANRS KECWFCLSSP SVESHLIVSV GESFYCALPK GSLVEDHILI
430 440 450 460 470 480
IPIEHLPNTL VLSPEVESEL SRYQNGLRNC YKSQGNDAVF FELVSKRVSH ANLQVVPVPS
490 500 510 520 530 540
SRARLLPNIF SLAAEKLGFK LVTKKFNDST DGRKYLQKEY NAALGLFYVE LPDGTVLSHT
550 560 570 580 590
LEENEVFPAQ FGREVLAGLL KIPDRADWRN CKISQEEEAK LAEDFKKQFQ EFDPCQ