Q83E35

PR
Gene name
tmk
Protein name
Thymidylate kinase
Names
dTMP kinase
Species
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
KEGG Pathway
cbu:CBU_0499
EC number
2.7.4.9: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

170-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q83E35

Entry ID Method Resolution Chain Position Source
AF-Q83E35-F1 Predicted AlphaFoldDB

No variants for Q83E35

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q83E35

No associated diseases with Q83E35

1 regional properties for Q83E35

Type Name Position InterPro Accession
domain Thymidylate kinase-like domain 15 - 204 IPR039430

Functions

Description
EC Number 2.7.4.9 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
uridylate kinase activity Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

4 GO annotations of biological process

Name Definition
dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
dUDP biosynthetic process The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKNMGIERG RFISFEGIEG VGKTTALNWV REQLDAARIP YVVTREPGGT PIAEAIRDVL
70 80 90 100 110 120
LSHSDEMMCP DTELLLMFAG RAQNIAHVVL PALRRGQWVL SDRFTDASFA YQGGGRGIPV
130 140 150 160 170 180
KHIEELAGWV LGNLKPDLTL LLDAPVSVGL CRVKSRGAKD RIEAEGLEFF KRVRECYLAL
190 200 210 220
ANQEPARFRV IHTDQDLSNV KNQIMKAIKP LLTASPLPGE KTEIEGL