Q83BB6

PR
Gene name
rpoD
Protein name
RNA polymerase sigma factor RpoD
Names
Sigma-70
Species
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
KEGG Pathway
cbu:CBU_1596
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q83BB6

Entry ID Method Resolution Chain Position Source
AF-Q83BB6-F1 Predicted AlphaFoldDB

No variants for Q83BB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q83BB6

No associated diseases with Q83BB6

12 regional properties for Q83BB6

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 486 - 499 IPR000943-1
domain RNA polymerase sigma-70 510 - 518 IPR000943-2
domain RNA polymerase sigma-70 634 - 646 IPR000943-3
domain RNA polymerase sigma-70 655 - 681 IPR000943-4
domain RNA polymerase sigma factor 70, region 1.1 102 - 172 IPR007127
domain RNA polymerase sigma-70 region 3 541 - 616 IPR007624
domain RNA polymerase sigma-70 region 2 462 - 531 IPR007627
domain RNA polymerase sigma-70 region 4 631 - 683 IPR007630
domain RNA polymerase sigma factor 70, non-essential domain 226 - 431 IPR007631
domain RNA polymerase sigma-70 region 1.2 185 - 215 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 458 - 694 IPR012760
domain RNA polymerase sigma-70 like domain 458 - 683 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSRKKKSSV TKTKKKTTGK KARVTAKAKP SVKSKLKTVK RAPAKPKSVT VAKTKSKKEK
70 80 90 100 110 120
AKVVSQPLPK TAEKKPSAPP SETQQPKIGE NAAESQRLGF GALLEEAKNK GYLVHEDLIN
130 140 150 160 170 180
LLPNDYADPS QMEGIIGRLT EMGIKVFEIP PDADSLLLEE DTQSDDDEIN EDVAEVLATE
190 200 210 220 230 240
TRTTDPVRMY MREMGSVELL TREGEIVIAK RIEEGIRQVM GAVVQYPELI EKFIKEYDTI
250 260 270 280 290 300
VATEGRLSDL LIGFFDEEES TASPVAPEAR DKEAETSDED DGGEGGSDEF GESGPDPLIT
310 320 330 340 350 360
QQHMEELKKL YGRYQNAIKR YGKKAPATLK HQKALAELFS TFKLSIKQFN RLTGQLRRML
370 380 390 400 410 420
RAARAQERLI MSYCVVKAKT PRKKFIASFP HNETNMKWLE QYKNENKEQA KRLEKYSKEI
430 440 450 460 470 480
YRAQRNLAQL EEQNNLNIQE IKEINRRVAI GEAKSRRAKK EMIEANLRLV ISIAKKYTNR
490 500 510 520 530 540
GLQFLDLIQE GNIGLMKAVD KFEYRRGYKF STYATWWIRQ AITRSIADQA RTIRIPVHMI
550 560 570 580 590 600
ETINKLNRIS RQILQETGIE ATPEELGRRM DMPEEKVRKV LKIAKEPISM ETPIGEDEDS
610 620 630 640 650 660
NLGDFIEDIN MESPVDFATS AGLMEATREI LSTLTPREAK VLRMRFGIDM NTDHTLEEVG
670 680 690
KQFDVTRERI RQIEAKALRK LRHPSRAEKL HSFIEVEE