Q83AL0

PR
Gene name
gshB
Protein name
Glutathione synthetase
Names
GSH synthetase, GSH-S, GSHase, Glutathione synthase
Species
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
KEGG Pathway
cbu:CBU_1875
EC number
6.3.2.3: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

200-272 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q83AL0

Entry ID Method Resolution Chain Position Source
AF-Q83AL0-F1 Predicted AlphaFoldDB

No variants for Q83AL0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q83AL0

No associated diseases with Q83AL0

3 regional properties for Q83AL0

Type Name Position InterPro Accession
domain Prokaryotic glutathione synthetase, N-terminal 3 - 121 IPR004215
domain Prokaryotic glutathione synthetase, ATP-binding 125 - 298 IPR004218
domain ATP-grasp fold 125 - 311 IPR011761

Functions

Description
EC Number 6.3.2.3 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutathione synthase activity Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
metal ion binding Binding to a metal ion.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLKVGVLMD PIANIAIHKD TTFAMLLALQ ARQHEVYYLE PADIFLRNEK ILGSMRRLQV
70 80 90 100 110 120
ADDPSQWFNL SESEIKPLHA LDVLLMRKDP PFNMSYVYLT YLLELAEKQG LFVVNKPASL
130 140 150 160 170 180
RDANEKLFTG WFPHCTPKTL VTSRKAILQE FIREQKEVVI KPLGAMAGES IFYLTVNDPN
190 200 210 220 230 240
IPVVIETMTA NGHQLVMAQR FIPEVKSGDK RIILIDGEPI PYTLARIPPK GDFRGNLARG
250 260 270 280 290 300
AKGEGRELTD RDRWICEQVG PTLRKKGLWF VGLDIIGDYL TEINVTSPTG VRELQAQFDV
310 320
DIAGQFIAFL ETKYATTTDI E