Q838K1

PR
Gene name
menE (EF_0446)
Protein name
2-succinylbenzoate--CoA ligase
Names
o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase
Species
Enterococcus faecalis (strain ATCC 700802 / V583)
KEGG Pathway
efa:EF0446
EC number
6.2.1.26: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-196 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q838K1

Entry ID Method Resolution Chain Position Source
AF-Q838K1-F1 Predicted AlphaFoldDB

No variants for Q838K1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q838K1

No associated diseases with Q838K1

3 regional properties for Q838K1

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 5 - 386 IPR000873
conserved_site AMP-binding, conserved site 144 - 155 IPR020845
domain AMP-binding enzyme, C-terminal domain 395 - 468 IPR025110

Functions

Description
EC Number 6.2.1.26 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
o-succinylbenzoate-CoA ligase activity Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate.

1 GO annotations of biological process

Name Definition
menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTWLNKQVQK RPDHPAFYFQ DESWTFLEVQ QEVSHWVATY QQVLAPEEKR VALFSKNSKE
70 80 90 100 110 120
LYFSILALWE LGKELLFLNT HLTLAELTFQ LKDAQVKTII GAPETQALLE EISFVDVQPM
130 140 150 160 170 180
IKKQHSLSHQ EFQQPSDLES VASIMYTSGT TGQPKGVLQR FKNHLASARG TQENMGITAE
190 200 210 220 230 240
DCWLCAVPLF HISGLSIVVR QLVLGCSIRL YDKFDEQQVT QDLQEGRGTV ISVVATMLQQ
250 260 270 280 290 300
LLSVYPEAGY SASFKGMLLG GGPIAPDKLA QCEEKGIPVI QSYGMTETCS QVVALKFEDA
310 320 330 340 350 360
ALKIGSAGQP LKDMQIKIVD ELGQEQPEKQ VGEILLKGPN VVSGYLNQRQ PEKWTADGWF
370 380 390 400 410 420
KTGDMGYLDA QSYLYLVSRL SELIISGGEN IYPTEVEQVL QAITGIKAAA VVGEPDAQWG
430 440 450 460 470 480
AVPVAYVISD QEITLAQIQD QCSRKLAKYK RPKRIYFCHS FPQTASGKIA KHRFMTEERE
AFLIR