Q835H3

PR
Gene name
mutS2
Protein name
Endonuclease MutS2
Names
Species
Enterococcus faecalis (strain ATCC 700802 / V583)
KEGG Pathway
efa:EF1404
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

659-733 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q835H3

Entry ID Method Resolution Chain Position Source
AF-Q835H3-F1 Predicted AlphaFoldDB

No variants for Q835H3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q835H3

No associated diseases with Q835H3

4 regional properties for Q835H3

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 327 - 512 IPR000432
domain Smr domain 710 - 788 IPR002625
domain DNA mismatch repair protein MutS, core 13 - 314 IPR007696
domain MutS2 and Smr-associated SH3 domain 645 - 684 IPR046893

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNQRILSTLG FDKVKQQLLQ FIVTAQGTNE VSELLPIADE NKIQSWLNET QDGLKVQRLR
70 80 90 100 110 120
GGIPIPKLEN IQPHMKRIEI GADLNGIELA QVGRVLSTTS ELTRFFDELS ENEVDFERLY
130 140 150 160 170 180
MWREQLEVLP ELNRQLKQAI DDDGYVTDEA SPALKAIRQN IRRSEQTIRE ELDSIIRGKN
190 200 210 220 230 240
ARYLSDALVT MRNERYVIPV KQEYKNIFGG VVHDQSASGQ TLFIEPKQIL EMNNRLRQQQ
250 260 270 280 290 300
IAERNEITRI LAELSAELVP YRREITHNAY VIGKLDFINA KARLGKELKA VVPEISQANH
310 320 330 340 350 360
VVFKQARHPL LNPEKAVAND IVIGEEYQAI VITGPNTGGK TITLKTLGLL QLMGQAGLPI
370 380 390 400 410 420
PVEEESKMGI FTEVFADIGD EQSIEQSLST FSSHMTNIVS VLKKVDHQSL VLFDELGAGT
430 440 450 460 470 480
DPQEGAALAI AILDSLGAKG AYVMATTHYP ELKVYGYNRA GTINASMEFD VDTLSPTYRL
490 500 510 520 530 540
LIGVPGRSNA FEISKRLGLD NSIIEAAKQI MDGESQDLNE MIEDLENRRK MAETEYLEAR
550 560 570 580 590 600
HYVDESAALH KELKEAYQVF FEEREKELQK ARKEANKIIA EAEENAETII SDIRKMQLES
610 620 630 640 650 660
GQQGGVKEHQ LIDAKTQLSQ LHHEETKLAK NKVLKKAKEQ KKLKAGDEVI VNTYGQRGTL
670 680 690 700 710 720
LKDNGKGQWQ VQLGILKMNV SEEDMTPVAP QKEAKPRVTT VRSAESSHVG TQLDLRGKRY
730 740 750 760 770 780
EEALAEVDQY IDAAILAGYP QVTIVHGKGT GALRTGITEF LKNHRSVKSY EFAPQNQGGN
GATVVKFQ