Q82ZW6

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Enterococcus faecalis (strain ATCC 700802 / V583)
KEGG Pathway
efa:EF2931
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-137 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q82ZW6

Entry ID Method Resolution Chain Position Source
AF-Q82ZW6-F1 Predicted AlphaFoldDB

No variants for Q82ZW6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q82ZW6

No associated diseases with Q82ZW6

5 regional properties for Q82ZW6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 48 - 59 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 20 - 564 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 607 - 753 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 813 - 877 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 563 - 698 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEEKNLPTK YQPTEIEAGR YQKWLDQDLF KPSGDKKAKP YSIVIPPPNV TGKLHLGHAW
70 80 90 100 110 120
DTTLQDMIIR QKRMQGFDTL WLPGMDHAGI ATQAKVEEKL AQQGISRYDL GREKFVDQVW
130 140 150 160 170 180
EWKEEYASHI REQWAKMGLS LDYSRERFTL DEGLSEAVRK VFVSLYEKDL IYRGEYIINW
190 200 210 220 230 240
DPKAKTALSD IEVIHKDIEG AFYHMSYPLS DGSGVVEIAT TRPETMLGDT AIAVHPEDER
250 260 270 280 290 300
YQELIGKTVV LPLVDKEIPI IADDYVDMEF GTGVVKITPA HDPNDFEVGN RHDLPRVNVM
310 320 330 340 350 360
NEDGTMNELA GKYEGMDRFA ARKAIVSDLK ELGRLIKIET MNHSVGHSER TGVVVEPRLS
370 380 390 400 410 420
TQWFVKMGPL AEKAMKNQET EDAVEFYPPR FNQTFLRWME NVHDWVISRQ LWWGHQIPAW
430 440 450 460 470 480
YHKETGEMYV GMEEPADSEN WVQDSDVLDT WFSSALWPFS TMGWPNEASE DYQRYFPTST
490 500 510 520 530 540
LVTGYDIIFF WVSRMIFQSL EFTGERPFQN VLIHGLIRDE QGRKMSKSLG NGIDPMDVIE
550 560 570 580 590 600
KYGADALRWF LSNGSAPGQD VRFSYEKMDA SWNFINKIWN ASRFVIMNVE GMTAADIDFS
610 620 630 640 650 660
GEKTVADRWI LTRLNETVAR VTELFDRFEF GEAGRQLYNF IWDDFCDWYI EMSKEILYGD
670 680 690 700 710 720
NEAAKQTTRS ILVYTLDQIL RLLHPIMPFV TEEIWEKIPH QGESLVVAEY PVVHEEFNDE
730 740 750 760 770 780
AAARGMEVLK EVIRSVRNIR AEVNTPLSKP ITLLIKTNDT EVEEFLTANT SYLERFCNPE
790 800 810 820 830 840
ELVISREIEA PELAMSAVLT GAELFLPLAG LINIEEEIAR LEKELDKWTK EVKRVQGKLS
850 860 870
NERFVSNAPD EVVEAERAKE KDYLEKQEAV KERIAQLRSI