Q82ZG8

PR
Gene name
gshAB
Protein name
Glutathione biosynthesis bifunctional protein GshAB
Names
Gamma-GCS-GS, GCS-GS
Species
Enterococcus faecalis (strain ATCC 700802 / V583)
KEGG Pathway
efa:EF3089
EC number
6.3.2.2: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q82ZG8

Entry ID Method Resolution Chain Position Source
AF-Q82ZG8-F1 Predicted AlphaFoldDB

No variants for Q82ZG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q82ZG8

No associated diseases with Q82ZG8

5 regional properties for Q82ZG8

Type Name Position InterPro Accession
domain Protein kinase domain 18 - 294 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 23 - 287 IPR001245
domain CARD domain 435 - 513 IPR001315
active_site Serine/threonine-protein kinase, active site 142 - 154 IPR008271
domain RIP2, CARD domain 437 - 522 IPR042149

Functions

Description
EC Number 6.3.2.2 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
glutathione synthase activity Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
metal ion binding Binding to a metal ion.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNYRELMQKK NVRPYVLMAR FGLEKENQRS TREGLLATTE HPTVFGNRSY HPYIQTDFSE
70 80 90 100 110 120
TQLELITPVA NSGTEMLRFL DAIHDVARRS IPEDEMLWPL SMPPQLPTKD EEIKIAKLDQ
130 140 150 160 170 180
YDAVLYRRYL AKEYGKRKQM VSGIHFNFEY DQALIQQLYD EQSEVTDCKQ FKTKVYMKVA
190 200 210 220 230 240
RNFLRYRWLI TYLFGASPVS EDRYFRVYDD QPQEPVRSIR NSTYGYRNHD NVKVSYASLE
250 260 270 280 290 300
RYLEDIHRMV ENGLLSEEKE FYAPVRLRGG KQMSDLPKTG IRYIELRNLD LNPFSRLGIV
310 320 330 340 350 360
EDTVDFLHYF MLYLLWTDEK EEADEWVKTG DIFNEQVALG HPHETIKLIA EGDRIFSEMI
370 380 390 400 410 420
DMLDALGIRK GKEVVGKYYQ QLRNPQDTVS GKMWTIIQEN SNSELGNIFG NQYQSMAFER
430 440 450 460 470 480
PYQLAGFREM ELSTQIFLFD AIQKGLEIEI LDEQEQFLKL QHGEHIEYVK NANMTSKDNY
490 500 510 520 530 540
VVPLIMENKT VTKKILSAAG FHVPGGEEFS SFIEAQEAHL RYANKAFVVK PKSTNYGLGI
550 560 570 580 590 600
TIFKEGASLE DFTEALRIAF KEDTAVLIEE FLPGTEYRFF VLDNDVKAIM LRVPANVTGD
610 620 630 640 650 660
GKHTVEELVA AKNSDPLRGT NHRAPLELIQ LNDLEKLMLK EQGLTIYSVP EKEQIVYLRE
670 680 690 700 710 720
NSNVSTGGDS IDMTDVIDDS YKQIAIEAVA ALGAKICGID LIIPDKDVKG TRDSLTYGII
730 740 750
EANFNPAMHM HVYPYAGQGR RLTMDVLKLL YPEVVQ