Q82U01

PR
Gene name
dxr
Protein name
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Names
DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase
Species
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
KEGG Pathway
neu:NE1712
EC number
1.1.1.267: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q82U01

Entry ID Method Resolution Chain Position Source
AF-Q82U01-F1 Predicted AlphaFoldDB

No variants for Q82U01

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q82U01

No associated diseases with Q82U01

3 regional properties for Q82U01

Type Name Position InterPro Accession
domain 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal 7 - 135 IPR013512
domain 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal 149 - 237 IPR013644
domain DXP reductoisomerase C-terminal domain 269 - 385 IPR026877

Functions

Description
EC Number 1.1.1.267 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH.
metal ion binding Binding to a metal ion.
NADPH binding Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

2 GO annotations of biological process

Name Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKTRHLTIL GSTGSIGEST LDVVARHPGR YQVVALTADR NVEKMFEQCI QFHPPYAVML
70 80 90 100 110 120
DAQSAEQLED RLHAAGLDTR VLSGIESLEK VASLPEIDTV MAAIVGAAGI RPTLAAARTG
130 140 150 160 170 180
KHILLANKET LVMAGRVFMD TLRQHHATLL PIDSEHNAIF QSLPQHFNGD LAGSGVRRIL
190 200 210 220 230 240
LTASGGPFRT VDLKILETVT PEQACAHPNW VMGRKISVDS ATMMNKGLEV IEAHWLFNAV
250 260 270 280 290 300
PEKIQVVIHP QSVIHSMVEY IDGSVLAQLG NPDMRTPIAH ALSYPERMES GVQSLDMFKV
310 320 330 340 350 360
ARLDFESPDF KRFPCLRLAY EALAAGGNMP AVLNAANEVA VEVFLAGRIP FTAIPVMIED
370 380 390 400 410
VMKSTERRDV PDLEGVLLAD LQARATAREW LACNIRQSTG QPGKPASSLS AGQ