Q82ML4

PR
Gene name
dxs1
Protein name
1-deoxy-D-xylulose-5-phosphate synthase 1
Names
1-deoxyxylulose-5-phosphate synthase 1, DXP synthase 1, DXPS 1
Species
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
KEGG Pathway
sma:SAVERM_1646
EC number
2.2.1.7: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-132 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q82ML4

Entry ID Method Resolution Chain Position Source
AF-Q82ML4-F1 Predicted AlphaFoldDB

No variants for Q82ML4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q82ML4

No associated diseases with Q82ML4

4 regional properties for Q82ML4

Type Name Position InterPro Accession
domain Transketolase, N-terminal 29 - 48 IPR005474
domain Transketolase-like, pyrimidine-binding domain 316 - 480 IPR005475
binding_site Transketolase binding site 422 - 438 IPR020826
domain Transketolase, C-terminal domain 499 - 612 IPR033248

Functions

Description
EC Number 2.2.1.7 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTMLENIRGP RDLKALSEAE LGELAEEIRE FLVHAVARTG GHLGPNLGVV ELSVALHRAF
70 80 90 100 110 120
ESPVDRILWD TGHQSYVHKL LTGRQDFSKL RSKGGLSGYP SREESEHDVI ENSHASTVLG
130 140 150 160 170 180
WADGLAKARQ VQGEKGHVVA VIGDGALTGG MAWEALNNIA AAKDRPLIIV VNDNERSYSP
190 200 210 220 230 240
TIGGLANHLA TLRTTDSYEK VLAWGKDVLL RTPVVGNTLY ESLHGAKKGF KDAFAPQGMF
250 260 270 280 290 300
EDLGLKYVGP IDGHDMKAME SAFRRAKRFH GPVLIHCLTE KGRGYEPALA HDEDRFHTVG
310 320 330 340 350 360
VMDPLTCEPL APSNGPSWTS VFGDEIVRIG EEREDVVAIT AAMLHPVGLN KFAEKFPGRV
370 380 390 400 410 420
WDVGIAEQHA AVSAAGLATG GLHPVVAVYA TFLNRAFDQL LMDVALHRCG VTFVLDRAGV
430 440 450 460 470 480
TGVDGASHNG MWDMSILQVV PGLRIAAPRD ADQLRAQLRE AVAVDDAPTL LRFPKESVGP
490 500 510 520 530 540
AIPAVDHVGG MDVLHRFPES PQVLLVAVGV MAPVCLQAAE LLEARGIGCT VVDPRWVKPV
550 560 570 580 590 600
DPSLPGLAAE HRLVAVVEDN SRAAGVGAAV ALALSDAEVD VPVRRFGIPE QFLAHAKRAE
610 620 630
VLADIGLTPV EIAGRISAGL ATKEELSKEK QE