Q82FV6

PR
Gene name
purC
Protein name
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Names
SAICAR synthetase
Species
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
KEGG Pathway
sma:SAVERM_4146
EC number
6.3.2.6: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

208-296 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q82FV6

Entry ID Method Resolution Chain Position Source
AF-Q82FV6-F1 Predicted AlphaFoldDB

No variants for Q82FV6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q82FV6

No associated diseases with Q82FV6

2 regional properties for Q82FV6

Type Name Position InterPro Accession
conserved_site SAICAR synthetase, conserved site 204 - 212 IPR018236
domain SAICAR synthetase/ADE2, N-terminal 16 - 295 IPR028923

Functions

Description
EC Number 6.3.2.6 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGFVEKPEP LQVPGLVHLH TGKVRDLYQN EAGDLVMVAS DRLSAFDWVL PTEIPDKGRV
70 80 90 100 110 120
LTQLSLWWFD RLVDLAPNHV LSTELPPGAP ADWQGRTLIC KSLKMEPVEC VARGYLTGSG
130 140 150 160 170 180
LVEYNETRTV CGLALPEGLV DGSELPGPIF TPATKAAVGE HDENVSYEEV ARQVGAETAA
190 200 210 220 230 240
KLRQTTLAVY ARARDIARRR GIILADTKFE FGFDGDTLVL ADEVLTPDSS RFWPADQWEP
250 260 270 280 290
GRAQPSFDKQ FVRDWLTSPE SGWDRKSEQP PPPLPQHVVD ATRAKYVEAY ERLTGANWS