Q82EX8
Gene name |
grpE1 |
Protein name |
Protein GrpE 1 |
Names |
HSP-70 cofactor 1 |
Species |
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) |
KEGG Pathway |
sma:SAVERM_4485 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q82EX8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q82EX8-F1 | Predicted | AlphaFoldDB |
No variants for Q82EX8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q82EX8 | |||||
No associated diseases with Q82EX8
16 regional properties for Q82EX8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 481 - 770 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 481 - 757 | IPR001245 |
| domain | Immunoglobulin subtype 2 | 53 - 114 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 170 - 238 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 269 - 349 | IPR003598-3 |
| domain | Immunoglobulin subtype | 47 - 125 | IPR003599-1 |
| domain | Immunoglobulin subtype | 164 - 249 | IPR003599-2 |
| domain | Immunoglobulin subtype | 263 - 360 | IPR003599-3 |
| domain | Immunoglobulin-like domain | 39 - 125 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 154 - 247 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 256 - 358 | IPR007110-3 |
| active_site | Tyrosine-protein kinase, active site | 622 - 634 | IPR008266 |
| domain | Immunoglobulin I-set | 172 - 248 | IPR013098-1 |
| domain | Immunoglobulin I-set | 264 - 359 | IPR013098-2 |
| binding_site | Protein kinase, ATP binding site | 487 - 517 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 481 - 757 | IPR020635 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenyl-nucleotide exchange factor activity | Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. |
| chaperone binding | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEETPGFDE | KPDVPSGATP | EDAEPKAAPS | EGAAPAGDAA | AAAQTAAQTA | GLTAQLDQVR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TALGERTADL | QRLQAEYQNY | RRRVERDRIA | VKEIAIANLL | TELLPTLDDI | GRAREHGELV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGFKSVAESL | ETVAAKMGLQ | QFGKEGEPFD | PTIHEALMHS | YAPDVTETTC | VAILQPGYRI |
| 190 | 200 | 210 | 220 | ||
| GERTIRPARV | AVAEPQPGAQ | TVKADEAEAA | DDKESGGPEE | G |