Q82EB2

PR
Gene name
cseC (SAV_4703)
Protein name
Sensor protein CseC
Names
Species
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
KEGG Pathway
sma:SAVERM_4703
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q82EB2

Entry ID Method Resolution Chain Position Source
AF-Q82EB2-F1 Predicted AlphaFoldDB

No variants for Q82EB2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q82EB2

No associated diseases with Q82EB2

4 regional properties for Q82EB2

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 359 - 472 IPR003594
domain HAMP domain 204 - 262 IPR003660
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 261 - 321 IPR003661
domain Histidine kinase domain 270 - 472 IPR005467

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGNLRRPGP AGTAGPGRTG IRTSADGGRA RPRTGAGTGV RAGVRSGVVG VGAGIRTGVR
70 80 90 100 110 120
WKISAAIALV GALVALALSL VVHNAARVSM LDNARDLADE RIQVAERMYE AGRAQSFGVK
130 140 150 160 170 180
LDDPAIPRDL MMKVTQGRRA TYVADGPHGV PDIWAAVPLK DGRVLSLHTR FTDRSADIMK
190 200 210 220 230 240
DLDQALIIGS IAVVFGGSAL GVLIGGQLSR RLRKAAAAAN QVAQGERDVR VRDAIGGVVR
250 260 270 280 290 300
DETDDLARAV DAMADALQQR IEAERRVTAD IAHELRTPVT GLLTAAELLP PGRPTELVRD
310 320 330 340 350 360
RAQAMRTLVE DVLEVARLDG ASERAELQDI MLGEFVSRRV AAKDADIEVR VVHESEVTTD
370 380 390 400 410 420
PRRLERVLFN LLANAARHGK PPIEVSVEGR VIRVRDHGPG FPEELLADGP RRFRTGSTDR
430 440 450 460 470 480
AGHGHGLGLT IAAGQARVLG ARLTFRNVRP AGAPGDVPAE GAVAVLWLPE HAPTNTGSFP
MLPLSGG