Q824C8

PR
Gene name
glyA
Protein name
Serine hydroxymethyltransferase
Names
SHMT, Serine methylase
Species
Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC) (Chlamydophila caviae)
KEGG Pathway
cca:CCA_00224
EC number
2.1.2.1: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q824C8

Entry ID Method Resolution Chain Position Source
AF-Q824C8-F1 Predicted AlphaFoldDB

No variants for Q824C8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q824C8

No associated diseases with Q824C8

4 regional properties for Q824C8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 10 - 21 IPR001412
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 4 - 321 IPR020058
domain Glutamyl-tRNA synthetase 5 - 329 IPR033910
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 336 - 480 IPR045462

Functions

Description
EC Number 2.1.2.1 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASLLHKFLE NASGKKGQDL ASTAYLAALD HLLHSFPSIG KSVIDELKGQ RSRLKMIASE
70 80 90 100 110 120
NYASISVQLA MGNLLTDKYC EGSPFKRFYS CCENVDAIEW ECAETAKELF GAESAFVQPH
130 140 150 160 170 180
SGADANLLAM MAIITQKIQG PAVKRLGYKT INDLTDKEYA ELKAEIGSHV CLGPSLNSGG
190 200 210 220 230 240
HLTHGTVRMN VMSKLMRCLP YEVNKKTERF DYAEIARLVR THKPTVLVAG YSSYSRRLNF
250 260 270 280 290 300
STLKQIADDC GAVLWVDMAH FAGLVAGGVF VEEENPIPFA DIVTTTTHKT LRGPRGGLVL
310 320 330 340 350 360
ASKEYDGIIN RACPLMMGGP LPHVIAAKAV ALKEALTVDF KKYAHQVVDN ARTLAEHFQK
370 380 390 400 410 420
QGLRLLTGGT DNHMLIIDLT SLGISGRIAE DILSSIGIAV NRNTIPSDAV GKWDTSGIRL
430 440 450 460 470 480
GTPALTTLGM GSDEMEEVAN IIVKVLRNIT LRRNADDSFS KSEGELPENI AQEARARVAD
490
LLSRFPLYPE IDLETLV