Q819Y5

PR
Gene name
polC
Protein name
DNA polymerase III PolC-type
Names
PolIII
Species
Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
KEGG Pathway
bce:BC3816
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q819Y5

Entry ID Method Resolution Chain Position Source
AF-Q819Y5-F1 Predicted AlphaFoldDB

No variants for Q819Y5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q819Y5

No associated diseases with Q819Y5

10 regional properties for Q819Y5

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 334 - 401 IPR003141
domain PHP domain 335 - 692 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 412 - 633 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 825 - 1005 IPR011708-1
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 1017 - 1092 IPR011708-2
domain Exonuclease, RNase T/DNA polymerase III 419 - 585 IPR013520
domain DNA polymerase III PolC-like, N-terminal domain II 98 - 207 IPR024754
domain DNA polymerase III PolC-type, N-terminal domain I 12 - 82 IPR028112
domain DNA polymerase, helix-hairpin-helix motif 1350 - 1426 IPR029460
domain DNA polymerase III alpha subunit finger domain 1096 - 1239 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLMSLTNEQQ ERFQILLQQL QIPDDLINQY LQGGGIERLV IDKANKSWHF DLQVPRILPT
70 80 90 100 110 120
ELYELLETKL KQSFSHIART TFALETENKQ FTEEEVRAYW PLCTERITFS PMFAYLKKQL
130 140 150 160 170 180
PQVNGVKLLI NVNNELESTA LKKNVAKPVG DQYEVFGFPR FQLDTHIQQN TEEMQKFREQ
190 200 210 220 230 240
TQQEDRERVI QAMEEMAKKQ AEESSVVYEG PITLGYLIKP DEEITPMREI QDEERRKTVQ
250 260 270 280 290 300
GYVFHVETKE LRSGRTLLTL KITDYTDSIM IKMFSRDKED IPMLQSLKKG MWVKARGSVQ
310 320 330 340 350 360
NDTFVRDLVM IANDINEITG PSRKDKAPEG EKRVELHLHT PMSQMDAVTP VSKLVAQAGK
370 380 390 400 410 420
WGHEAIAVTD HAVAQSFPEA YSAGKKAGVK VIYGVEANLV NDGVPIAYNE AHRLLAEETY
430 440 450 460 470 480
VVFDVETTGL SAVYDTVIEL AAVKVKGGEI IDRFESFANP HQPLSATIIE LTGITDDMLT
490 500 510 520 530 540
DAPEVDEVFK KFEEWMGDHT LVAHNASFDM GFINVGFKKA GLEKTNNPVI DTLELARFLF
550 560 570 580 590 600
PEMKNHRLNT MCKKLDIELT QHHRAIYDTE ATGYLLVKML KDVIEKGFEY HDQLNDSMGQ
610 620 630 640 650 660
GDAYKRGRPS HMTLLATSDV GLKNLYKLVS YSHLNYFYRV PRVPRSLLKK YREGILVGTA
670 680 690 700 710 720
CDKGEVFEAM MQKAPEEVEE IAQFYDYIEV MPPEVLRHLV ERELVRDEGQ LKTIISNLVK
730 740 750 760 770 780
LGETLDKPVV ATGNVHYLDP EDAMYRKILV SSQGGANPLN RHSLPPVHFR TTDEMLECFS
790 800 810 820 830 840
FLGEDKAKEV VVTNTQKIAS LIGDVHPVKD DLYTPKIEGA DDETRDMSYK MARSIYGEEL
850 860 870 880 890 900
PEIVEARLEK ELKSIIGHGF AVIYLISHKL VKKSLVDGYL VGSRGSVGSS FVATMMEITE
910 920 930 940 950 960
VNPLPPHYVC PKCKQSEFFN DGSVGSGFDL PDKECPACNI PYVKDGHDIP FETFLGFKGD
970 980 990 1000 1010 1020
KVPDIDLNFS GEYQPRAHNY TKVLFGEDYV YRAGTIGTVA EKTAYGYVKG YANDHNLTIR
1030 1040 1050 1060 1070 1080
NAEIDRLVAG CTGVKRTTGQ HPGGIIVVPD YMDIFDFSPI QYPADSIGAE WRTTHFDFHS
1090 1100 1110 1120 1130 1140
IHDNLLKLDI LGHDDPTVIR MLQDLSGIDP KTIPTDDPEV MKIFSGPESL GVTEEQINCK
1150 1160 1170 1180 1190 1200
TGTLGIPEFG TKFVRQMLEE TKPTTFSELV QISGLSHGTD VWLGNANELI YNGTCTLSEV
1210 1220 1230 1240 1250 1260
IGCRDDIMVY LIYQGLDPSL AFKIMESVRK GKGVPEEWEE DMKNNNVPGW YIDSCKKIKY
1270 1280 1290 1300 1310 1320
MFPKAHAAAY VLMAVRIAYF KVHFALLFYA AYFTVRADDF DVEAMAKGSA SIRARIDEIA
1330 1340 1350 1360 1370 1380
QKGLDAAPKE KSLLTVLEMT LEMCERGYSF QKVDLYRSHA TEFIIDGDTL IPPFNAVPGL
1390 1400 1410 1420 1430
GTNAALSIVE ARKNGDFLSK EDLQQRSKVS KTIIEYLDSQ GCLGDLPDQN QLSLF