Q811Q9
Gene name |
Pcyt1b |
Protein name |
Choline-phosphate cytidylyltransferase B |
Names |
EC 2.7.7.15 , CCT-beta , CTP:phosphocholine cytidylyltransferase B , CCT B , CT B , Phosphorylcholine transferase B |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
mmu:236899 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
202-223 (alphaE helices within the catalytic domain) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q811Q9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q811Q9-F1 | Predicted | AlphaFoldDB |
24 variants for Q811Q9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411126243 | 4 | L>I | No | EVA | |
| rs3389579040 | 68 | R>C | No | EVA | |
| rs3389515980 | 96 | L>R | No | EVA | |
| rs3389561854 | 101 | T>A | No | EVA | |
| rs3411335969 | 110 | V>A | No | EVA | |
| rs3389516000 | 136 | L>P | No | EVA | |
| rs3389567697 | 174 | S>F | No | EVA | |
| rs3410322443 | 189 | G>D | No | EVA | |
| rs3389561878 | 202 | T>I | No | EVA | |
| rs3389516039 | 212 | D>N | No | EVA | |
| rs3411016149 | 218 | R>W | No | EVA | |
| rs3389576627 | 268 | E>D | No | EVA | |
| rs3389525434 | 281 | K>N | No | EVA | |
| rs3389577491 | 298 | A>T | No | EVA | |
| rs3389564482 | 299 | W>S | No | EVA | |
| rs3389569820 | 337 | T>I | No | EVA | |
| rs3408679663 | 354 | A>S | No | EVA | |
| rs3409831804 | 356 | A>P | No | EVA | |
| rs3409831804 | 356 | A>S | No | EVA | |
| rs3409831834 | 360 | S>C | No | EVA | |
| rs3411284620 | 363 | E>* | No | EVA | |
| rs3389561879 | 363 | E>G | No | EVA | |
| rs3411506422 | 365 | D>G | No | EVA | |
| rs3389569762 | 369 | K>* | No | EVA |
No associated diseases with Q811Q9
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| choline-phosphate cytidylyltransferase activity | Catalysis of the reaction |
| phosphatidylcholine binding | Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-choline pathway | The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. |
| ovarian follicle development | The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. |
| phosphatidylcholine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49585 | PCYT1A | Choline-phosphate cytidylyltransferase A | Homo sapiens (Human) | SS |
| Q9Y5K3 | PCYT1B | Choline-phosphate cytidylyltransferase B | Homo sapiens (Human) | PR |
| P49586 | Pcyt1a | Choline-phosphate cytidylyltransferase A | Mus musculus (Mouse) | SS |
| P19836 | Pcyt1a | Choline-phosphate cytidylyltransferase A | Rattus norvegicus (Rat) | EV |
| Q9QZC4 | Pcyt1b | Choline-phosphate cytidylyltransferase B | Rattus norvegicus (Rat) | PR |
| F4JJE0 | CCT2 | Choline-phosphate cytidylyltransferase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSILYALVAR | GTVVLAELST | TSTNASTIAK | QILEKIPGNG | DSHVSYSQDR | YVFHVKRTDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTVLCMADED | AGRRIPFSFL | EDIHQRFVRT | YGRAIHSAQA | YAMNDEFSRV | LNQQIEYYSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPNADTISRI | KGEMNQVRDV | MIENIDNILD | RGERLELLVD | KTANMQGNTF | RFRKQTRRFN |
| 190 | 200 | 210 | |||
| NTVWWRNCKL | TLLLILVLLV | IIYIGVAFAC | HGPTLPSCV |