Q80ZJ6
Gene name |
Zer1 |
Protein name |
Protein zer-1 homolog |
Names |
Zyg-11 homolog B-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:227693 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80ZJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80ZJ6-F1 | Predicted | AlphaFoldDB |
28 variants for Q80ZJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3391420466 | 47 | C>S | No | EVA | |
| rs3388542201 | 69 | T>A | No | EVA | |
| rs3388542485 | 132 | V>L | No | EVA | |
| rs258623195 | 137 | S>F | No | EVA | |
| rs3388543768 | 145 | E>K | No | EVA | |
| rs3388539320 | 160 | P>T | No | EVA | |
| rs3391357105 | 171 | F>V | No | EVA | |
| rs3410683798 | 175 | S>R | No | EVA | |
| rs3388539242 | 215 | T>S | No | EVA | |
| rs3388544936 | 223 | S>T | No | EVA | |
| rs3388541985 | 246 | H>Y | No | EVA | |
| rs3388539391 | 251 | K>R | No | EVA | |
| rs3391330228 | 260 | I>M | No | EVA | |
| rs3388541031 | 291 | L>P | No | EVA | |
| rs3388543429 | 333 | R>W | No | EVA | |
| rs3388542146 | 379 | H>R | No | EVA | |
| rs3388541045 | 406 | A>T | No | EVA | |
| rs3388541944 | 422 | N>Y | No | EVA | |
| rs3388542011 | 423 | I>F | No | EVA | |
| rs3388542011 | 423 | I>V | No | EVA | |
| rs3388542348 | 467 | V>M | No | EVA | |
| rs3388539380 | 470 | N>K | No | EVA | |
| rs3388542017 | 520 | V>I | No | EVA | |
| rs3388543405 | 560 | S>P | No | EVA | |
| rs3388544343 | 613 | E>K | No | EVA | |
| rs3388541810 | 625 | Q>K | No | EVA | |
| rs3388538158 | 631 | S>R | No | EVA | |
| rs3412967341 | 702 | L>I | No | EVA |
No associated diseases with Q80ZJ6
5 regional properties for Q80ZJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 440 - 480 | IPR000225-1 |
| repeat | Armadillo | 524 - 569 | IPR000225-2 |
| repeat | Armadillo | 571 - 613 | IPR000225-3 |
| repeat | Armadillo | 615 - 656 | IPR000225-4 |
| repeat | Armadillo | 727 - 769 | IPR000225-5 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| Cul2-RING ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein quality control for misfolded or incompletely synthesized proteins | The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7Z7L7 | ZER1 | Protein zer-1 homolog | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASDTPESLM | ALCTDFCLRN | LDGTLGYLLD | KETLRLHPDI | FLPSEICDQL | VNEYVELVSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ACTFEPHETF | FSLFSDPRST | RLTRIHLRED | LVQDQDLEAI | RKQDLVELYL | TNCEKLSAKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQTLRSFRHS | LVSLSLSGCA | NIFYEEDNPG | GCEDECLVNP | TCQVLVKDFT | FEGFSRLRFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NLGRMIDGIP | VESLLRPLNS | LAALDLSGIQ | TSDATFLTQW | KDSLMSLVLY | NMDLSDDHIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIVQLHKLRS | KILTCGPHLI | SSHLDISRDR | LSSYYKFKLT | RKVLSLLVQK | LGNLMSLDIS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GHMILENCSI | SKTDEEAGQT | STEPSKSSIM | PFRALKRPLQ | FLGLFETSLC | RLTHIPAYKV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGDKNEEQVL | NAIEAYTEHR | PEITSRAINL | LFDIARIERC | NQLLRALKLV | ITALKCHKYD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KNIQVTGSAA | LFYLTNSEYR | SEQSVKLRRQ | VIQVVLNGME | SYQEVTVQRN | CCLTLCNFSI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PEELEFQYRR | VNELLLGILS | PTRQDESIQR | IAVHLCNALV | CQVDNDHKEA | VGKMGFVVTM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKLIQKKLLD | KTCDQVMEFS | WSALWNITDE | TPDNCEMFLN | FNGMKLFLDC | LKEFPEKQEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HRNMLGLLGN | VAEVKELRPQ | LMTSQFISVF | SNLLESKADG | IEVSYNACGV | LSHIMFDGPE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AWGVCEPQRA | EVEDRMWAAI | QSWDINSRRN | INYRSFEPIL | RLLPQGISPV | SQHWATWALY |
| 730 | 740 | 750 | 760 | 770 | |
| NLVSVYPDKY | CPLLIKEGGM | PLLRDLIKMA | TARQETKEMA | RKVIEHCSNF | REENMDTSR |