AiPD: Autoinhibited Protein Database

Gene name	Cnksr2 (Kiaa0902)
Protein name	Connector enhancer of kinase suppressor of ras 2
Names	Connector enhancer of KSR 2, CNK homolog protein 2, CNK2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:245684
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

651-725 (Predicted disordered autoinhibitory region) PR

651-725 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q80YA9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3412781008	69	A>T	No	EVA
rs3389559949	72	L>P	No	EVA
rs3389559989	75	A>V	No	EVA
rs1132423844	97	K>*	No	EVA
rs1135352438	98	N>Y	No	EVA
rs1132622623	103	I>T	No	EVA
rs3412573792	105	G>V	No	EVA
rs3389579659	107	R>*	No	EVA
rs3389574127	109	S>R	No	EVA
rs3389590523	111	H>L	No	EVA
rs3389592903	194	V>I	No	EVA
rs3389590456	224	S>G	No	EVA
rs3412565533	235	Y>*	No	EVA
rs3412394158	244	T>S	No	EVA
rs3412572880	247	N>K	No	EVA
rs3412572840	266	N>I	No	EVA
rs3412565253	296	R>P	No	EVA
rs3412393367	297	P>L	No	EVA
rs3389548575	324	R>K	No	EVA
rs3412476830	408	E>D	No	EVA
rs3389581361	444	V>L	No	EVA
rs3389592966	451	D>N	No	EVA
rs3412475897	473	S>Y	No	EVA
rs3411039207	482	Y>C	No	EVA
rs3412647916	485	Q>H	No	EVA
rs3412571459	485	Q>L	No	EVA
rs3412647890	486	R>*	No	EVA
rs216636923	507	A>T	No	EVA
rs247338304	508	H>Q	No	EVA
rs239782804	522	Q>P	No	EVA
rs3412475860	536	H>Q	No	EVA
rs3389574674	539	Q>*	No	EVA
rs3389574124	550	K>N	No	EVA
rs3389590485	554	A>T	No	EVA
rs3389584554	561	R>K	No	EVA
rs3389577399	563	I>T	No	EVA
rs3389574594	579	K>N	No	EVA
rs3389592949	580	K>Q	No	EVA
rs3389584560	583	A>T	No	EVA
rs3389590527	646	S>R	No	EVA
rs3412359706	654	L>H	No	EVA
rs3412830274	708	D>G	No	EVA
rs3389539132	722	Y>*	No	EVA
rs3412570231	757	P>R	No	EVA
rs3409737656	763	S>R	No	EVA
rs3412570214	767	S>C	No	EVA
rs3412357944	769	Q>L	No	EVA
rs3389574111	818	Q>H	No	EVA
rs3389581274	829	S>G	No	EVA
rs3389592893	856	C>F	No	EVA
rs3389592946	902	K>R	No	EVA
rs3389548556	952	R>M	No	EVA
rs3389584494	978	D>V	No	EVA
rs3389532609	1009	S>N	No	EVA

Type	Name	Position	InterPro Accession
domain	PDZ domain	215 - 297	IPR001478
domain	Sterile alpha motif domain	8 - 76	IPR001660
domain	Pleckstrin homology domain	570 - 671	IPR001849
domain	Connector enhancer of kinase suppressor of ras 2/3 domain	340 - 495	IPR010599
domain	CRIC domain	84 - 178	IPR017874

		Description
EC Number
Subcellular Localization	Cytoplasm Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extrinsic component of postsynaptic density membrane	The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic membrane	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
postsynapse organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
regulation of signal transduction	Any process that modulates the frequency, rate or extent of signal transduction.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins