Q80XM9
Gene name |
Slc66a2 (Pqlc1) |
Protein name |
Solute carrier family 66 member 2 |
Names |
PQ-loop repeat-containing protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66943 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80XM9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80XM9-F1 | Predicted | AlphaFoldDB |
11 variants for Q80XM9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389504866 | 9 | L>P | No | EVA | |
| rs3389508058 | 28 | G>V | No | EVA | |
| rs3389523488 | 35 | P>T | No | EVA | |
| rs3389515454 | 41 | R>W | No | EVA | |
| rs3407735873 | 70 | G>T* | No | EVA | |
| rs3389507971 | 75 | S>C | No | EVA | |
| rs3389469862 | 92 | L>M | No | EVA | |
| rs3389490607 | 148 | Q>P | No | EVA | |
| rs3389490549 | 178 | A>V | No | EVA | |
| rs3389469849 | 182 | E>D | No | EVA | |
| rs3389469848 | 268 | T>S | No | EVA |
No associated diseases with Q80XM9
2 regional properties for Q80XM9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | PQ-loop repeat | 18 - 76 | IPR006603-1 |
| repeat | PQ-loop repeat | 171 - 229 | IPR006603-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phospholipid translocation | The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N2U9 | SLC66A2 | Solute carrier family 66 member 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAEGLGWLL | VPLHQLVSWV | AAGAMVFGGV | VPYIPQYRDI | RRTQNADGFS | THVCLVLLVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NILRILFWFG | RHFESPLLWQ | SIVMILTMLL | MLKLCTEVRV | ANELNIKRRS | FAATDSKDEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRVPPRRPYL | DFDPHHFWHW | SSFSDYVQCV | LAFTGVAGYI | TYLSIDSALF | VETLGFLAVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TEAMLGVPQL | YRNYCHRSTE | GMSLKMVLMW | TSGDTFKTAY | FLLNGAPLQF | SVCGLLQVMV |
| 250 | 260 | 270 | |||
| DLVILGQAYA | FAHHPQKPAA | HAVHPASTKA | L |