Q80X82
PR
Gene name |
Sympk |
Protein name |
Symplekin |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68188 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80X82
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80X82-F1 | Predicted | AlphaFoldDB |
47 variants for Q80X82
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3397821641 | 3 | S>I | No | EVA | |
| rs3388867776 | 12 | R>L | No | EVA | |
| rs3388886551 | 30 | M>I | No | EVA | |
| rs3388886499 | 66 | D>E | No | EVA | |
| rs3388863670 | 85 | S>F | No | EVA | |
| rs3388881564 | 171 | L>I | No | EVA | |
| rs3388883941 | 172 | L>W | No | EVA | |
| rs3397263435 | 182 | H>D | No | EVA | |
| rs3397625086 | 182 | H>Q | No | EVA | |
| rs3397711444 | 185 | K>E | No | EVA | |
| rs242637735 | 236 | V>L | No | EVA | |
| rs3397586284 | 332 | Q>* | No | EVA | |
| rs3396883907 | 332 | Q>P | No | EVA | |
| rs3388886485 | 353 | T>I | No | EVA | |
| rs3388872159 | 471 | Q>E | No | EVA | |
| rs3388880160 | 536 | G>S | No | EVA | |
| rs3388886865 | 554 | T>K | No | EVA | |
| rs3388858752 | 558 | V>M | No | EVA | |
| rs3388858804 | 591 | S>N | No | EVA | |
| rs3388880176 | 598 | S>P | No | EVA | |
| rs3388881647 | 659 | Q>* | No | EVA | |
| rs3388858812 | 686 | C>* | No | EVA | |
| rs3388885072 | 721 | S>N | No | EVA | |
| rs3388890172 | 744 | Q>E | No | EVA | |
| rs3388883971 | 748 | Y>H | No | EVA | |
| rs3388883940 | 752 | F>S | No | EVA | |
| rs3388886928 | 768 | V>M | No | EVA | |
| rs3412824827 | 805 | I>M | No | EVA | |
| rs3388875455 | 823 | V>M | No | EVA | |
| rs3388890156 | 829 | Q>E | No | EVA | |
| rs3388881579 | 831 | I>F | No | EVA | |
| rs3411747127 | 832 | R>L | No | EVA | |
| rs3388863677 | 835 | G>D | No | EVA | |
| rs3388883883 | 849 | P>L | No | EVA | |
| rs3388886488 | 880 | L>V | No | EVA | |
| rs3388876292 | 938 | S>F | No | EVA | |
| rs3388881582 | 942 | P>S | No | EVA | |
| rs3388867763 | 996 | M>K | No | EVA | |
| rs3388881632 | 1005 | S>T | No | EVA | |
| rs3388872166 | 1013 | G>E | No | EVA | |
| rs3397724017 | 1015 | F>I | No | EVA | |
| rs3397626352 | 1015 | F>L | No | EVA | |
| rs3388875464 | 1021 | A>S | No | EVA | |
| rs263068246 | 1205 | V>I | No | EVA | |
| rs246216032 | 1267 | A>T | No | EVA | |
| rs6211046 | 1271 | A>T | No | EVA | |
| rs3397626392 | 1281 | E>D | No | EVA |
No associated diseases with Q80X82
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mRNA cleavage and polyadenylation specificity factor complex | A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nuclear stress granule | A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| mRNA polyadenylation | The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
| negative regulation of protein binding | Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. |
| positive regulation of protein dephosphorylation | Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92797 | SYMPK | Symplekin | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASSSGDSVT | RRSVASQFFT | QEEGPSIDGM | TTSERVVDLL | NQAALITNDS | KITVLKQVQE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIINKDPTLL | DNFLDEIIAF | QADKSIEVRK | FVIGFIEEAC | KRDIELLLKL | IANLNMLLRD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENVNVVKKAI | LTMTQLYKVA | LQWMVKSRVI | SDLQEACWDM | VSSMAGEIIL | LLDSDNDGIR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| THAIKFVEGL | IVTLSPRMAD | SEVPRRQEHD | ISLDRIPRDH | PYIQYNVLWE | EGKAAVEQLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFMVHPAISS | INLTTALGSL | ANIARQRPMF | MSEVIQAYET | LHANLPPTLA | KSQVSSVRKN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKLHLLSVLK | HPASLEFQAQ | ITTLLVDLGT | PQAEIARNMP | SSKDSRKRPR | DDTDSTLKKM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLEPNLGEDD | EDKDLEPGPS | GTSKASAQIS | GQSDTDITAE | FLQPLLTPDN | VANLVLISMV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLPETMPASF | QAIYTPVESA | GTEAQIKHLA | RLMATQMTAA | GLGPGVEQTK | QCKEEPKEEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VVKPESVLIK | RRLSVQGQAI | SVVGSQSTMS | PLEEEVPQAK | RRPEPIIPVT | QPRLAGAGGR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKIFRLSDVL | KPLTDAQVEA | MKLGAVKRIL | RAEKAVACSG | AAQVRIKILA | SLVTQFDSGF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KAEVLSFILE | DVRARLDLAF | AWLYQEYNAY | LAAGTSGTLD | KYEDCLICLL | SGLQEKPDQK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DGIFTKVVLE | APLITESALE | VIRKYCEDES | RAYLGMSTLG | DLIFKRPSRQ | FQYLHVLLDL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSHEKDRVRS | QALLFIKRMY | EKEQLREYVE | KFALNYLQLL | VHPNPPSVLF | GADKDTEVAA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PWTEETVKQC | LYLYLALLPQ | NHKLIHELAA | VYTEAIADIK | RTVLRVIEQP | IRGMGMNSPE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LLLLVENCPK | GAETLVTRCL | HSLTDKVPPS | PELVKRVRDL | YHKRLPDVRF | LIPVLNGLEK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KEVIQALPKL | IKLNPIVVKE | VFNRLLGTQH | GEGNSALSPL | NPGELLIALH | NIDSVKCDMK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SIIKATNLCF | AERNVYTSEV | LAVVMQQLME | QSPLPMLLMR | TVIQSLTMYP | RLGGFVMNIL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ARLIMKQVWK | YPKVWEGFIK | CCQRTKPQSF | QVILQLPPQQ | LGAVFDKCPE | LREPLLAHVR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SFTPHQQAHI | PNSIMTILEA | TGKQEPEVKE | APSGPLEEDD | LEPLALALAP | APAPAPAPAP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| APAPAPRPPQ | DLIGLRLAQE | KALKRQLEEE | QKQKPTGIGA | PAACVSSTPS | VPAAARAGPT |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PAEEVMEYRE | EGPECETPAI | FISMDDDSGL | AETTLLDSSL | EGPLPKEAAA | VGSSSKDERS |
| 1270 | 1280 | ||||
| PQNLSHAVEE | ALKTSSPETR | EPESKGNS |