| adult walking behavior |
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. |
| bone mineralization |
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. |
| CAAX-box protein processing |
The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. |
| calcium ion import into sarcoplasmic reticulum |
The directed movement of calcium ions into a sarcoplasmic reticulum. |
| CAMKK-AMPK signaling cascade |
The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. |
| cardiac conduction |
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. |
| cardiac muscle cell development |
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. |
| cardiac ventricle development |
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. |
| cellular lipid metabolic process |
The chemical reactions and pathways involving lipids, as carried out by individual cells. |
| cellular response to DNA damage stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| cellular response to gamma radiation |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. |
| chromatin organization |
The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| chromosome organization |
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. |
| determination of adult lifespan |
The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| DNA repair |
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| epidermis development |
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. |
| growth plate cartilage development |
The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. |
| hair follicle development |
The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. |
| heart morphogenesis |
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| histone H2B acetylation |
The modification of histone H2B by the addition of an acetyl group. |
| histone H2B-K5 acetylation |
The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone. |
| hypomethylation of CpG island |
An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. |
| inflammatory cell apoptotic process |
Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. |
| kidney morphogenesis |
Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. |
| liver development |
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| maintenance of rDNA |
Any process involved in sustaining the fidelity and copy number of rDNA repeats. |
| multicellular organism growth |
The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| negative regulation of gene expression |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of miRNA maturation |
Any process that stops, prevents or reduces the frequency, rate or extent of maturation of miRNAs. |
| neuromuscular process |
Any process pertaining to the functions of the nervous and muscular systems of an organism. |
| nuclear envelope organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. |
| nucleus organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. |
| positive regulation of gene expression |
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| prenylated protein catabolic process |
The chemical reactions and pathways resulting in the breakdown of prenylated proteins. |
| protein processing |
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
| regulation of autophagy |
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| regulation of blood circulation |
Any process that modulates the frequency, rate or extent of blood circulation. |
| regulation of bone mineralization |
Any process that modulates the frequency, rate or extent of bone mineralization. |
| regulation of cell shape |
Any process that modulates the surface configuration of a cell. |
| regulation of cellular senescence |
Any process that modulates the frequency, rate or extent of cellular senescence. |
| regulation of defense response to virus |
Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. |
| regulation of DNA damage response, signal transduction by p53 class mediator |
Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. |
| regulation of DNA methylation |
Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. |
| regulation of DNA-templated transcription |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of fibroblast proliferation |
Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
| regulation of glucose metabolic process |
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. |
| regulation of heart contraction |
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. |
| regulation of histone H4 acetylation |
Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. |
| regulation of histone H4-K16 acetylation |
Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation. |
| regulation of hormone metabolic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. |
| regulation of lipid metabolic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. |
| regulation of mitotic cell cycle |
Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
| regulation of mitotic cell cycle DNA replication |
Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication. |
| regulation of multicellular organism growth |
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
| regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. |
| regulation of stress-activated protein kinase signaling cascade |
Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. |
| regulation of termination of RNA polymerase I transcription |
Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription. |
| regulation of TOR signaling |
Any process that modulates the frequency, rate or extent of TOR signaling. |
| regulation of ventricular cardiac muscle cell membrane repolarization |
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. |
| response to DNA damage checkpoint signaling |
A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling. |
| thymus development |
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. |
| ventricular cardiac muscle tissue development |
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. |
