Q80VH0
PR
Gene name |
Bank1 |
Protein name |
B-cell scaffold protein with ankyrin repeats |
Names |
Protein AVIEF |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:242248 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80VH0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80VH0-F1 | Predicted | AlphaFoldDB |
57 variants for Q80VH0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388662092 | 27 | K>E | No | EVA | |
| rs266067918 | 33 | Y>H | No | EVA | |
| rs3388660477 | 34 | E>G | No | EVA | |
| rs3388667124 | 41 | A>V | No | EVA | |
| rs3388663416 | 51 | V>D | No | EVA | |
| rs221130279 | 61 | P>T | No | EVA | |
| rs3388667113 | 74 | N>Y | No | EVA | |
| rs30260564 | 75 | F>L | No | EVA | |
| rs238346737 | 76 | Y>N | No | EVA | |
| rs3388660484 | 79 | K>* | No | EVA | |
| rs3411153015 | 92 | D>V | No | EVA | |
| rs3388669370 | 125 | Y>F | No | EVA | |
| rs3393808352 | 159 | E>G | No | EVA | |
| rs3388663459 | 166 | I>S | No | EVA | |
| rs30774411 | 170 | S>A | No | EVA | |
| rs3388663881 | 172 | A>G | No | EVA | |
| rs3388667133 | 193 | S>Y | No | EVA | |
| rs252761437 | 233 | N>S | No | EVA | |
| rs262764415 | 249 | H>R | No | EVA | |
| rs230222930 | 249 | H>Y | No | EVA | |
| rs232134504 | 264 | I>V | No | EVA | |
| rs3388666521 | 273 | T>I | No | EVA | |
| rs3388669299 | 274 | T>P | No | EVA | |
| rs3388665301 | 277 | K>N | No | EVA | |
| rs264987856 | 288 | P>A | No | EVA | |
| rs217762324 | 303 | I>V | No | EVA | |
| rs229356426 | 318 | I>M | No | EVA | |
| rs247292160 | 328 | A>T | No | EVA | |
| rs3393742061 | 363 | Q>P | No | EVA | |
| rs3393695898 | 369 | R>S | No | EVA | |
| rs3393703727 | 369 | R>T | No | EVA | |
| rs50828248 | 375 | A>T | No | EVA | |
| rs47442962 | 375 | A>V | No | EVA | |
| rs3393490680 | 381 | L>P | No | EVA | |
| rs247828554 | 410 | K>E | No | EVA | |
| rs259009459 | 417 | E>D | No | EVA | |
| rs235211583 | 425 | Y>C | No | EVA | |
| rs232479266 | 433 | A>T | No | EVA | |
| rs3388665269 | 455 | S>C | No | EVA | |
| rs3388653030 | 458 | M>K | No | EVA | |
| rs3388653030 | 458 | M>R | No | EVA | |
| rs3388662111 | 458 | M>V | No | EVA | |
| rs3412942325 | 460 | E>G | No | EVA | |
| rs3388654609 | 463 | A>T | No | EVA | |
| rs211935347 | 469 | R>P | No | EVA | |
| rs3388667090 | 491 | P>S | No | EVA | |
| rs215417754 | 541 | S>N | No | EVA | |
| rs230416925 | 569 | E>Q | No | EVA | |
| rs3388663891 | 634 | F>L | No | EVA | |
| rs3388669296 | 660 | M>T | No | EVA | |
| rs212531533 | 668 | T>I | No | EVA | |
| rs3388665247 | 686 | V>I | No | EVA | |
| rs3388667097 | 700 | F>L | No | EVA | |
| rs3388654627 | 703 | W>C | No | EVA | |
| rs3388654586 | 704 | Q>* | No | EVA | |
| rs3388665284 | 747 | G>S | No | EVA | |
| rs258380885 | 783 | H>N | No | EVA |
No associated diseases with Q80VH0
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| phospholipase binding | Binding to a phospholipase. |
| protease binding | Binding to a protease or a peptidase. |
| protein tyrosine kinase binding | Binding to protein tyrosine kinase. |
| signaling adaptor activity | The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell activation | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of B cell activation | Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. |
| negative regulation of interleukin-6 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. |
| negative regulation of protein kinase B signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| negative regulation of translational initiation | Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of peptidyl-tyrosine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| protein kinase B signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NDB2 | BANK1 | B-cell scaffold protein with ankyrin repeats | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLPVASGTRG | STQDLFQVGL | APPGNAKDIL | LLYEEDAEEW | ALYLREIFMR | VVEREAILLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLHSFSSSHL | EMLNFYAYKC | KLLIISNSLL | KDLTPKKCQF | LEKILHSTGN | VVTLLCGMES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDPFYQLLSI | PRKRWEISTE | QDPDGYISVI | RQILDQGPED | YLEVSIPTDS | RAKYPEDTSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QKGTDVLASL | RPSVPRVLVL | PGEIPCEKPG | EIFILLKDEL | IGEILEVEFI | STNKRLRARP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ARWNKSVWHM | KAADFPAGSV | TVNIHCDGII | KATTEIKYCS | AAKATESPFR | VSDPGKSLCQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSIEELDNVL | ASIFKREIPY | YEFKHLQAET | YPQKERTHTT | ELPTLLHCAA | KFGLKNLALH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLQCSGATRA | ARMKATDGSD | LLHIAERHGH | EELKEVFEDF | LSQNTGRNSK | QENDYEEDVI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFSTYSPSMP | SPASLHELRK | THRRNTDRSE | EPERSVEMKE | EEAGAEARRS | LSEGERESSE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQYDDLYVFI | PGFDTEGNSE | EPLPHCRPPL | LPPRPGTAAS | QLERPHFTSQ | GKVLEDQMER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SQNWNDLNAR | PETREESSRE | EKKEEAQEEE | EEEENPYAFA | ETEDNEYDLI | LASKSVKKRT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GNRSFIINRP | PAPTPRPTHI | PPKEETTPYI | AQVFQQKAAR | RQSDGDKFYS | LPKKPDKTRM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EGPTFPSTRD | YLTTGQEELI | LLQERVKNGK | MSVDEALEKF | KHWQMGKSGL | EMIQQEKLRQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRDNIIGKRP | EDENAYDKLT | IVHHPSGNTA | HNENMLYNSP | FNSKFPARIQ | VEKEFGFCCK |
| KDH |