Q80UP5
Gene name |
Ankrd13a (Ankrd13) |
Protein name |
Ankyrin repeat domain-containing protein 13A |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68420 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80UP5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80UP5-F1 | Predicted | AlphaFoldDB |
30 variants for Q80UP5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388774803 | 33 | N>K | No | EVA | |
| rs3388777505 | 70 | E>K | No | EVA | |
| rs3388774857 | 87 | P>S | No | EVA | |
| rs3388753745 | 114 | H>Q | No | EVA | |
| rs3388753700 | 116 | I>F | No | EVA | |
| rs3396094000 | 120 | P>L | No | EVA | |
| rs3388753705 | 160 | T>I | No | EVA | |
| rs3388783361 | 167 | M>K | No | EVA | |
| rs3388783363 | 182 | D>Y | No | EVA | |
| rs3388777487 | 291 | K>R | No | EVA | |
| rs3395685653 | 296 | D>A | No | EVA | |
| rs3396083163 | 306 | T>S | No | EVA | |
| rs3388774872 | 307 | V>E | No | EVA | |
| rs3388775238 | 321 | C>G | No | EVA | |
| rs3388784236 | 346 | D>N | No | EVA | |
| rs3388783441 | 368 | E>D | No | EVA | |
| rs3388772151 | 374 | L>F | No | EVA | |
| rs3388772134 | 390 | A>D | No | EVA | |
| rs3388753741 | 397 | D>E | No | EVA | |
| rs3388764402 | 401 | L>V | No | EVA | |
| rs3388783355 | 429 | N>Y | No | EVA | |
| rs3388783276 | 460 | V>I | No | EVA | |
| rs3388781229 | 483 | Y>* | No | EVA | |
| rs3388753667 | 486 | M>L | No | EVA | |
| rs3388776345 | 490 | I>F | No | EVA | |
| rs3388769532 | 498 | S>C | No | EVA | |
| rs3388781233 | 499 | R>T | No | EVA | |
| rs3395685659 | 527 | Q>HVG* | No | EVA | |
| rs3388789585 | 551 | D>V | No | EVA | |
| rs253772767 | 566 | R>Q | No | EVA |
No associated diseases with Q80UP5
1 regional properties for Q80UP5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Olfactomedin-like domain | 230 - 489 | IPR003112 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin-dependent protein binding | Binding to a protein upon ubiquitination of the target protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of protein localization to endosome | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endosome. |
| negative regulation of receptor internalization | Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IZ07 | ANKRD13A | Ankyrin repeat domain-containing protein 13A | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSARDTSSR | FPLHLLVWNN | DYEQLEKELR | DQNAEALDPR | GRTLLHLAVS | LGHLESARVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRHKADVTKE | NGQGWTVLHE | AVSTGDPEMV | YTVLQHRDYH | NTSMALEGVP | ELLHKILEAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFYVQMKWEF | TSWVPLVSRI | CPNDVCRIWK | SGAKLRVDIT | LLGFENMSWI | RGRRSFIFKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GDNWAELMEV | NHDDRVVTTE | HFDLSQEMER | LTLDLMKPKS | REVERRLTSP | VINTSLDTKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAFERTKSGF | WGWRTDKAEV | VNGYEAKVYS | VNNVSVITRI | RTEHLTEEEK | KRYKEDRNPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESLLGTVEHQ | FGAQGDLATE | CATVNNPTAI | TPDEYFDEDF | DLKDRDIGRP | KELTIRTQKF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KATLWMCEEF | PLSLVEQVIP | IIDLMARTSA | HFARLRDFIK | LDFPPGFPVK | IEIPLFHVLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ARITFGNVNG | CSTADESQGV | EGTPAEAVSE | ATNFEVDQSV | FEIPESYHIQ | DNGRNVHLQD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EDYEIMQFAI | QQSLLESSRS | QDLSGPASNG | GVSHTHSYEA | QYERAIQESL | LTNMEGRCPG |
| 550 | 560 | 570 | 580 | ||
| GLSESSRFDS | DLQLAMELSA | KELAERELRL | QEEEAELQQV | LQLSLTEK |