Q80T69

PR
Gene name
Rsbn1 (Kiaa3002, Rsbn)
Protein name
Lysine-specific demethylase 9
Names
KDM9, Round spermatid basic protein 1, Rosbin
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:229675
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q80T69

Entry ID Method Resolution Chain Position Source
AF-Q80T69-F1 Predicted AlphaFoldDB

16 variants for Q80T69

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388655829 30 R>* No EVA
rs3388643662 37 V>I No EVA
rs3388644253 58 V>L No EVA
rs3388652508 218 E>* No EVA
rs3388647034 276 K>N No EVA
rs3388643725 339 T>A No EVA
rs3388655071 340 H>Q No EVA
rs3388643701 403 N>I No EVA
rs3393019862 405 K>S No EVA
rs3388643681 493 E>A No EVA
rs3388659261 499 E>* No EVA
rs3388651522 586 V>G No EVA
rs3388655851 588 Q>R No EVA
rs3388648586 688 T>A No EVA
rs3388648588 706 P>L No EVA
rs3393440483 740 R>S No EVA

No associated diseases with Q80T69

No regional properties for Q80T69

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q80T69

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
histone H4-methyl-lysine-20 demethylase activity Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5VWQ0 RSBN1 Lysine-specific demethylase 9 Homo sapiens (Human) PR
10 20 30 40 50 60
MFRSTRTTDQ WRVGERLQCP AGHARAALAR TADGGAVGPF KCVFVGEMAA QVGAVRVVRA
70 80 90 100 110 120
VAAQEEPDKE GKEKPHVGVS PRGVKRQRRA SSGGSQEKRG RPSQDPPLAP PHRRRRSRQH
130 140 150 160 170 180
PGPLPPTNAA PTVPGPVEPL LLPPPPPPSL APAGPTVAAP LPAPGTSALF TFSPLTVSAA
190 200 210 220 230 240
GPKHKGHKER HKHHHHRGSD GDPGACVPGD LKHKDKQENG ERSGGVPLIK APKRETADEN
250 260 270 280 290 300
GKTQRADDFV LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQLNS
310 320 330 340 350 360
TSGVNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFTTH QEHSIRRNFL KTGTKFSNFI
370 380 390 400 410 420
HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF SENEKNAAYY ALAIVHGAAA
430 440 450 460 470 480
YLPDFLDYFA FNFPNTPVKM EILGKKDIET TTISNFHTQV NRTYCCGTYR AGPMRQISLV
490 500 510 520 530 540
GAVDEEVGDY FPEFLDMLEE SPFLKMTLPW GTLSSLQLQC RSQSDDGPIM WVRPGEQMIP
550 560 570 580 590 600
TADMPKSPFK RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
610 620 630 640 650 660
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV DEAKLNQMRR
670 680 690 700 710 720
EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR LKQYHPVVET AQNTESNSNM
730 740 750 760 770 780
DCGLEVDSQC VRIKTESEER CTEMQLLTTA SPSFPPPSEL HLQDLKTQPL PVFKVESRLD
790
SDQQHSLQAH PSTPV