Q80KJ7

PR
Gene name
ORF1
Protein name
Non-structural polyprotein 1AB
Names
Species
Mink astrovirus 1 (MAstV-1)
KEGG Pathway
vg:29200741
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

630-714 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q80KJ7

Entry ID Method Resolution Chain Position Source

No variants for Q80KJ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q80KJ7

No associated diseases with Q80KJ7

2 regional properties for Q80KJ7

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, C-terminal domain 913 - 1305 IPR001205
domain RNA-directed RNA polymerase, catalytic domain 1122 - 1254 IPR007094

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • Host membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell membrane Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANNTTSALH PRGSGQRCVY DTVLRFGDPD ARRRGFQLDE VSHNKLCDIF DSGPLHFAFG
70 80 90 100 110 120
DLKVMKVAGG VVTPHKTVVK TVYVSGVQEG NDYVTFAFTP GPNEWREVDP RIDKRTALVG
130 140 150 160 170 180
VLVQEHKKLD SDLKESRREL SQLKLEHSLL RHDYERLVRE KPGPAMRTFK FSAVIFYAFF
190 200 210 220 230 240
LGFLLMSAVK GEVYGRCLDS ELNLNGNPEV CLHWEEVKSF SLQVALADFW NMTLDYYATV
250 260 270 280 290 300
APQSPLMDLA LGYFPYFANW HMAAFLVGTA HVVAAERPLY MLVTLVLATL SRFQLVALAA
310 320 330 340 350 360
VPMLDMPSSI GLWVTMVLFA IDQAFAILAS VLISVLLLIL CLAMNDVDYG ALLRGCVTLV
370 380 390 400 410 420
SATVFSHLVS FLHAPGWFTI IAILIYRIPK VLSYVSAERV DIKGPDGKIK ETQNANPSWI
430 440 450 460 470 480
TKMSGLKNFF QRAFRQKVRT GVNPTTRIIP NSLVVIDAKD GRGTGFRVRN YLVTAGHVVG
490 500 510 520 530 540
ADTTVRVRWA DVTSFAHVVY RVPNKDIVLL TLPAEYNSLH SYKLAKEVVD GTVVVVSNGD
550 560 570 580 590 600
GGALSVGISE GVIVGESMTY AINTADGMSG SPLTTTDGRL IGVHQQNTGF TGGAVIFRDT
610 620 630 640 650 660
DFPQPKKPQR EADLEAKVAE LEKALAAYTQ SATGEDIVGL VRVAIQREME VLRKELSNEF
670 680 690 700 710 720
GQAKGKTKHK RRIMAAARSG GKRKPGKVWT EEEYKKLLEE GFTRDQLREM AEAAREADDD
730 740 750 760 770 780
FDDYEEEKNE VDYPVWSDHD SDEEIDRDWF GQNLPTWSSA WSDFEPELDP DVTKTLPCHL
790 800 810 820 830 840
EDKFSLKHYI ITEADLKHFG QEMKEYMDHL DAVIKTHTEK GKWCPNTNTE EILKDLNAMW
850 860 870 880 890 900
FKLNHTMWKN GVAPFMQRKK QKPKKREEGP ERGPINPDEM RLDHWEKMMA PPDAGRRLVP
910 920 930 940 950 960
DDYPVIGKLP INRPISDWDE PVDDLLNLLP PAPDSSAYGP AVWGPEAYVK SFEKFTYAKP
970 980 990 1000 1010 1020
RDSIKRDFPR EWKFACQVLR REFDFLEGSV IMDITATSKN ADSTCAYPKC NYWKTEAEYL
1030 1040 1050 1060 1070 1080
SERGYQDYVS EYKRIHGGAR PKVLWLLFLK KEILKVKKIN DSDIRQIVCA DPIFARIGNA
1090 1100 1110 1120 1130 1140
FEEHQNTLMK HRTATRMPQC GWTPFFNGFK RRIERLLSRK NSVFIEFDWT RYDGTIPREI
1150 1160 1170 1180 1190 1200
FAKIKSFRFS CLAEEFQTDA NRAMYQWYCD SLLDRYVLMP SGEVTRQTKG NPSGQISTTM
1210 1220 1230 1240 1250 1260
DNNLCNVFFQ AFEYAYIHPE KSIEELRESW DRCDSLIYGD DRLTTFDHVP PDYVDRVVHM
1270 1280 1290 1300 1310 1320
YKDVFGMWVK PEKVIVSDTP VGLSFCGFTV GPDLMPVPTD CDKLVASLVT PTKKLQDIVA
1330 1340 1350 1360 1370 1380
LYSKVLCYRI LGHNLSDEHE FKRYVRVALE VLARHIRNLG GEEPVHVTER LLDKLWRGGP
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