Q802A6

PR
Gene name
STK4
Protein name
Serine/threonine-protein kinase 3/4
Names
STE20-like kinase MST1/2, sMST1/2
Species
Squalus acanthias (Spiny dogfish)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

168-191 (Activation loop from InterPro)

Target domain

32-283 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q802A6

Entry ID Method Resolution Chain Position Source
AF-Q802A6-F1 Predicted AlphaFoldDB

No variants for Q802A6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q802A6

No associated diseases with Q802A6

4 regional properties for Q802A6

Type Name Position InterPro Accession
domain Protein kinase domain 32 - 283 IPR000719
domain SARAH domain 437 - 484 IPR011524
binding_site Protein kinase, ATP binding site 38 - 61 IPR017441
domain Mst1 SARAH domain 437 - 484 IPR024205

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • The caspase-cleaved form cycles between nucleus and cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEVQRRQHP HPRRSLKKLS EDSLTKQPEE VFDVLEKLGE GSYGSVFKAI HKESGQVVAI
70 80 90 100 110 120
KQVPVESDLQ EIIKEISIMQ QCDSPHVVKY YGSYFKNTDL WIVMEYCGAG SVSDLIRIRN
130 140 150 160 170 180
KTLTEDEIAT ILQSTLKGLE YLHFMRKIHR DIKAGNILLN NEGHAKLADF GVAGQLTDTM
190 200 210 220 230 240
AKRNTVIGTP FWMAPEVIQE IGYNCVADIW SLGISAIEMA EGKPPYADIH PMRAIFMIPT
250 260 270 280 290 300
NPPPTFRKPE LWTDEFTDFV KQCLVKNPEQ RAAATQLLQH PFIKNAKPVS ILRDLITDMM
310 320 330 340 350 360
EIKLKRQEEQ QRDLDQDDEE NSEEDDMDSG TMVRASAEDT GTMRAASTLS DGARTMIEHD
370 380 390 400 410 420
SSTLDSQMGT MVINSGEDEE DGTMKRKEET IQQSKPSFLE YFEQKEKENQ ANSHSNRNAQ
430 440 450 460 470 480
ALQNSSDNWK VPQDGDFESL KSWSVEELQR RLASLDPTME QEIEEIRQRY QAKRQPILDA
490
IDAKKRWQQN F