Q7ZXK3

PR
Gene name
stat3.2 (stat3-a)
Protein name
Signal transducer and activator of transcription 3.2
Names
Protein Stat3-A
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:379264
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-230 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZXK3

Entry ID Method Resolution Chain Position Source
AF-Q7ZXK3-F1 Predicted AlphaFoldDB

No variants for Q7ZXK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZXK3

No associated diseases with Q7ZXK3

5 regional properties for Q7ZXK3

Type Name Position InterPro Accession
domain SH2 domain 580 - 674 IPR000980
domain STAT transcription factor, protein interaction 2 - 122 IPR013799
domain STAT transcription factor, all-alpha domain 145 - 312 IPR013800
domain STAT transcription factor, DNA-binding 326 - 464 IPR013801
domain STAT3, SH2 domain 554 - 715 IPR035855

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the nucleus and the cytoplasm
  • Constitutive nuclear presence is independent of tyrosine phosphorylation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

4 GO annotations of biological process

Name Definition
mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE SHATLVFHNL
70 80 90 100 110 120
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSTYLEKPME IARIVARCLW EEGRLLQTAV
130 140 150 160 170 180
AAAQQGGPAS HPNAAVITEK QQMLEQHLQD VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK
190 200 210 220 230 240
SQSDLSELNG NNQSVTRQKM QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKNLTDEEL
250 260 270 280 290 300
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IRKLEELQQK VSYKGDPIVQ
310 320 330 340 350 360
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR LLVKFPELNY
370 380 390 400 410 420
QLKIKVCIDK DSGEGAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
430 440 450 460 470 480
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
490 500 510 520 530 540
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
550 560 570 580 590 600
GCQITWAKFC KENMAGKGFS FWVWLDNLID LVKKYMLALW NEGYIIGFIS KERERALLSP
610 620 630 640 650 660
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM
670 680 690 700 710 720
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP GTAPYLRTMF ICVTPTTCTL
730 740 750 760
DLPMSPGTFD SVMQFPGEGS ESGNGNQFET LTFDVDLPSE CAASPM