Q7ZXH1
Gene name |
dhcr7 |
Protein name |
7-dehydrocholesterol reductase |
Names |
7-DHC reductase, Sterol Delta(7)-reductase |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:379273 |
EC number |
1.3.1.21: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7ZXH1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7ZXH1-F1 | Predicted | AlphaFoldDB |
No variants for Q7ZXH1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7ZXH1 | |||||
No associated diseases with Q7ZXH1
2 regional properties for Q7ZXH1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Sterol reductase, conserved site | 211 - 226 | IPR018083-1 |
| conserved_site | Sterol reductase, conserved site | 437 - 460 | IPR018083-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.21 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7-dehydrocholesterol reductase activity | Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. |
| NADP binding | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGERRRANAS | RGDKKVANGE | KQHVGQWGRA | WEVDYFSLAS | VIFLLAFAPL | IVYYFVMSCD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QYQCALTAPV | LDLYSGKARL | SDIWDKTPAL | TWTAVKIYLA | WVSFQVFLYM | FLPDILHKFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGYEGGVQEG | ARTPAGLINK | YQVNGLQAWT | ITHLLWFANA | YHFHWFSPTI | VIDNWIPLLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CANLLGYSVA | TFALVKANFF | PTNANDCKFT | GNFFYDYMMG | IEFNPRIGKW | FDFKLFFNGR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGIVAWTLIN | LSYAAKQQEL | YGQVTNSMIL | VNVLQAIYVV | DFFWNESWYL | KTIDICHDHF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GWYLGWGDCV | WLPYLYTLQG | LYLVYNPVEL | STTAAVAVLL | LGLIGYYIFR | MTNHQKDLFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTNGNCKIWG | KKPKSIECFY | VSADGKRHYS | KLMISGFWGV | ARHLNYTGDL | MGSLAYCLAC |
| 430 | 440 | 450 | 460 | 470 | |
| GFDHLLPYFY | FIYMTILLVH | RCIRDEHRCS | SKYGKDWKLY | TSAVPYRLLP | GLF |