Q7ZXB1
Gene name |
mcm7-b (cdc47-2) |
Protein name |
DNA replication licensing factor mcm7-B |
Names |
CDC47 homolog B, CDC47-2p, Minichromosome maintenance protein 7-B, xMCM7-B |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:380414 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q7ZXB1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8Q6O | EM | 314 A | 7/F | 1-720 | PDB |
| 8Q6P | EM | 353 A | 7 | 1-720 | PDB |
| AF-Q7ZXB1-F1 | Predicted | AlphaFoldDB |
No variants for Q7ZXB1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7ZXB1 | |||||
No associated diseases with Q7ZXB1
6 regional properties for Q7ZXB1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MCM domain | 321 - 540 | IPR001208 |
| domain | AAA+ ATPase domain | 372 - 525 | IPR003593 |
| conserved_site | Mini-chromosome maintenance, conserved site | 439 - 447 | IPR018525 |
| domain | MCM N-terminal domain | 9 - 138 | IPR027925 |
| domain | MCM OB domain | 148 - 277 | IPR033762 |
| domain | MCM, AAA-lid domain | 557 - 639 | IPR041562 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| regulation of DNA-templated DNA replication initiation | Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRDYQAEKE | KCKTFLQEFY | KDDEFGKKNF | KYGVQLANIA | HREQVALCID | LDDLAEEDPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVDAICENTR | RYTNLFADAV | QELLPQYKER | EVVHKDALDV | YIEHRLMMEQ | RGRDPNEMRD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PHNQYPPELM | RRFELYFKAP | SSSKARVVRD | VKADSIGKLV | TVRGIVTRVT | EVKPMMVVAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YTCDQCGAET | YQPIQSPTFM | PLIMCPSREC | QTNRSGGRLY | LQTRGSKFIK | FQELKIQEHS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DQVPVGNIPR | CMSVYVRGEN | TRLAQPGDHV | GITGVFLPML | RTGFRQVVQG | LLSETYLESH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLVKMNKTED | DELGTEELSE | EELRQITEED | FYEKLAASIA | PEIYGHEDVK | KALLLLLVGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VDHSPRGMKI | RGNINVCLMG | DPGVAKSQLL | SYIDRLAPRS | QYTTGRGSSG | VGLTAAVMKD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PVTGEMTLEG | GALVLADQGV | CCIDEFDKMM | DSDRTAIHEV | MEQQTISIAK | AGIMTTLNAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CSILAAANPA | YGRYNPKKTV | EQNIQLPAAL | LSRFDLLWLI | QDKPDRDNDL | RLAQHITYVH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QHSKQPPSQF | QPMDMKLMRR | YITMCKSKQP | AIPESLADYL | TAAYVEMRKE | ARTNKDMTFT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SARTLLSILR | LSTALARLRL | EDVVEKEDVN | EAMRLTEMSK | DSLQGDKGHA | SRTQRPADVI |
| 670 | 680 | 690 | 700 | 710 | |
| FSTIREMVPE | KGARSVKYSE | AEQRCVSKGF | TPAQFEAALE | EYEELNVWLV | NQARTKITFV |