Q7ZWS1

PR
Gene name
dus3l
Protein name
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
Names
mRNA-dihydrouridine synthase DUS3L, tRNA-dihydrouridine synthase 3-like
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:379349
EC number
1.3.1.89: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZWS1

Entry ID Method Resolution Chain Position Source
AF-Q7ZWS1-F1 Predicted AlphaFoldDB

No variants for Q7ZWS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZWS1

No associated diseases with Q7ZWS1

5 regional properties for Q7ZWS1

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 123 - 153 IPR000571-1
domain Zinc finger, CCCH-type 161 - 191 IPR000571-2
conserved_site tRNA-dihydrouridine synthase, conserved site 380 - 398 IPR018517
domain DUS-like, FMN-binding domain 296 - 531 IPR035587
domain E3 ligase, CCCH-type zinc finger 127 - 151 IPR041367

Functions

Description
EC Number 1.3.1.89 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
metal ion binding Binding to a metal ion.
tRNA dihydrouridine synthase activity Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
tRNA dihydrouridine synthesis The process whereby a uridine in a transfer RNA is converted to dihydrouridine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAESEGSNTE NGKVGAVKSE NLDRGVAAIK NQFLTTKEKF HAFIDADGKD VTEKETCSEL
70 80 90 100 110 120
SLNDAENTTR TENAAEPEAK RIKLDDGSSE GQDQPPKTAE NKQEKKRARG QNKSRPHMKH
130 140 150 160 170 180
SQFEENKLCP SVTQECASKC FFGDKCKFSH DVAKYVSQKP EDIRPNCHLY ETFGKCIYGV
190 200 210 220 230 240
TCRFAKSHLG EDFKNIINEE LMKEWEGKVL VKNSLDKSLK EQLRKKKVVF EKSDKYLKLC
250 260 270 280 290 300
FKSGDSSKMK NPVVKEDSAV QVTQKDSPIT TVGAVTDEDV IKLRPCEKKT IDFRNKLYLA
310 320 330 340 350 360
PLTTCGNLPF RRICKRLGAD ITCGEMAMCT NLLQGQPSEW ALLKRHHSED IFGVQLEGAF
370 380 390 400 410 420
PDTMTKCAEL LNRTIDVDFV DINVGCPIDL VYKKGGGCGL MNRTNKFEQI VKGMNSVLDV
430 440 450 460 470 480
PLTVKIRTGV QEKVNIAHKL IPNLRDWGVS LVTLHGRSRE QRYTKLANWE YIDQCAKIAS
490 500 510 520 530 540
PVPLFGNGDI ISYEDANRAL QTGVAGVMLA RGALFKPWLF TEIKEQRHWD ISSTERFDIL
550 560 570 580 590 600
KDFTNYGLEH WGSDCQGVEK TRKFMLEWLS FLCRYIPVGL LEHVPQKINE RPPYYMGRDY
610 620 630
LETLMASQNV TDWIKISEML LGPVPPNFTF LPKHKANSYK