Q7ZVM1
Gene name |
washc5 |
Protein name |
WASH complex subunit 5 |
Names |
WASH complex subunit strumpellin |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:393152 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7ZVM1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7ZVM1-F1 | Predicted | AlphaFoldDB |
No variants for Q7ZVM1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7ZVM1 | |||||
No associated diseases with Q7ZVM1
No regional properties for Q7ZVM1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q7ZVM1 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| WASH complex | A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament polymerization | Assembly of actin filaments by the addition of actin monomers to a filament. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| endosome fission | The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. |
| endosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. |
| heart contraction | The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of actin nucleation | Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12768 | WASHC5 | WASH complex subunit 5 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDFLAENNL | CGQAILRIVS | RGNAIIAELL | RLSDFIPAVF | RLRDKTDQQK | YGDIICDFSY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKGPEYYEGK | LEAKPELQDL | DEEFRENNIE | ILTRFYLAFE | SVHKYVVDLI | RCLDDLNEGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIQQTLETVL | LNEDGKQLLC | EALYLYGVML | LVIDQKMEGE | VRERMLVSYY | RYSAARSSAD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SNLDDICKLL | RSTGYSSHPG | AKRPTNYPES | YFQRVPISST | FISMVIGRLR | SDDIYNQVSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YPLPEHRSTA | LATQAAMLYV | CLYFTPSILH | TQQAKMREIV | DKYFPDNWVI | SIYMGITVNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEAWEPYKAA | KIALNYTLDT | ANIREQAGRY | AASVETLRPQ | VQQLLKEGFL | REEIILDNIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLLNCLRDCN | VAIRWLMLHT | AESAYDPNNK | RLRQIKDQVI | NDSKYNPKIL | FQLLLDTAQF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EFILKEMFKQ | MLAEKQLKWE | SYKKEGSERM | MELAEVFSGV | KPLTRVEKNE | NLQAWFREIS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KQIESLNYED | STAAGRKTVQ | LIQALVEVQE | FHQLESNLQV | CQFLADTRKF | LHQMIRTINI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KEEVLITMQI | VGDLSYAWQI | IDSFTAIMQE | SIRANPSMVT | KLRATLLKLA | SALDLPLLRI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NQVNSPDLLS | VSQFYSGELV | AYVRKVLQII | PESMFTSLAK | IIKLQIHDIM | EVPTRLDKDK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LKDYSQLSAR | YEVAKLTHAI | SVFTEGILMM | KTTLVGIIQV | DPKQLLEDGI | RKELVKRVAY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALHKGLIFNP | KAKPSELMPK | LKEMAATMDG | FYRSFEYIQD | YVSIYGLKIW | QEEVSRIINY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NVEQECNSFL | RTKIQDWQSV | HQSTHIPIPK | YPSVDESATF | IGRLCREILR | ITDPKVTCYI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DQLNTWYDLR | THQEVTNNRL | FSEIQDTLGT | FGLNGLDRLL | CFMIVKELQN | FLTVLQKSIL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KDKAVVDVFK | ALLTAVNPVK | GIVANASKVY | TNAAAKTQKI | WSPYLESIMK | VGQMQILRQQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IANELNYSCK | FDSKHLAAAL | DNLNKSLLSD | IEAHYQDPSL | PYPKEDNTLL | YEITAYLEAA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GIHNPLNKIY | ITTKRLPYFP | IVNFLFLIAQ | LPKLQYNKSQ | GMACRKPADA | LDWAPLVLGL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LTLLKQFHSR | YTEQFLALIG | QFIRSIMEQC | TSQKIPDMPS | DVVGALMFLE | DYVRYTKLPR |
| 1150 | |||||
| KVAEAHVPSF | IFDEFRTVL |