Q7ZVL2

PR
Gene name
wdr24
Protein name
GATOR complex protein WDR24
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:406336
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

436-642 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZVL2

Entry ID Method Resolution Chain Position Source
AF-Q7ZVL2-F1 Predicted AlphaFoldDB

No variants for Q7ZVL2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZVL2

No associated diseases with Q7ZVL2

6 regional properties for Q7ZVL2

Type Name Position InterPro Accession
repeat WD40 repeat 62 - 97 IPR001680-1
repeat WD40 repeat 103 - 186 IPR001680-2
repeat WD40 repeat 190 - 239 IPR001680-3
repeat WD40 repeat 238 - 276 IPR001680-4
repeat WD40 repeat 280 - 321 IPR001680-5
conserved_site WD40 repeat, conserved site 217 - 231 IPR019775

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Lysosome membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GATOR2 complex A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
cellular response to amino acid starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
positive regulation of TORC1 signaling Any process that activates or increases the frequency, rate or extent of TORC1 signaling.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKMTRVSTI NGRTMFCHLD APANAISVCR DATQVVVAGR NIFKIYGLEE DGFVERLNLR
70 80 90 100 110 120
VGRKPSLNFS CADVMWHQME ENLLATAATN GAVVTWNLSR PCRNKQEQLF TEHKRTVNKV
130 140 150 160 170 180
CFHPTEVNML LSGSQDGFMK CFDLRKKESV STFSGQSESV RDVQFSMKDY FTFAASFENG
190 200 210 220 230 240
NVQLWDIRRP DRYERMFTAH TGPVFCCDWH PEDRGWLATG GRDKMVKVWD MSTNRVKEIY
250 260 270 280 290 300
CVQTFASVAR VKWRPERRYH LATCSMMVDH NIYVWDVRRP FIPFATFEEH KDVTTGIVWR
310 320 330 340 350 360
HQHDPYFLLS GSKDSTLYQH MFKDASRPVD RANPEGLCFG LFGDLAFAAK ESLMSAPASA
370 380 390 400 410 420
GDVGRKTYPG GDRRYPIFFF KKPDVTEQFA QVSSALSVFE SEADSSAGMD WFINTAQSYL
430 440 450 460 470 480
LSGKPFAELC EHNAHVAKSL NRPQESTTWT MLRIMFSEPA NPSLSTNHNL NKSGNLPLVN
490 500 510 520 530 540
SFSMKEMSGA LNERNKENRQ DNIHSLETNL NNNDENEETE GSEGQAEYLF VDDELDDDEL
550 560 570 580 590 600
YSMEHDNQPA EESEYLLPQE AFPLRHEIMD HPSAPEPLQE KQESPHVSGS EAESMCLTPM
610 620 630 640 650 660
ESFSLISVSQ QLFSPHLPPK FFCPIVKEML CYYAEQGDVQ MAVSVLIVLG DRIRKEIDEL
670 680 690 700 710 720
MQEHWYMSYI DLLQRFELWN VSNEVIKLST CGAIMCLNQA STTLHINCSN CKRPMSNKGW
730 740 750 760 770
ICDRCHQCAS VCAVCHHVVK GLFVWCQGCS HGGHLEHVME WLKQSKHCPA GCGHLCEYT