Q7ZV14

PR
Gene name
gpx8 (zgc:56280)
Protein name
Probable glutathione peroxidase 8
Names
GPx-8, GSHPx-8
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393191
EC number
1.11.1.9: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZV14

Entry ID Method Resolution Chain Position Source
AF-Q7ZV14-F1 Predicted AlphaFoldDB

No variants for Q7ZV14

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZV14

No associated diseases with Q7ZV14

2 regional properties for Q7ZV14

Type Name Position InterPro Accession
domain Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal 180 - 320 IPR006109
domain Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal 7 - 160 IPR011128

Functions

Description
EC Number 1.11.1.9 Peroxidases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
glutathione peroxidase activity Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

1 GO annotations of biological process

Name Definition
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS YEVKDARGRT
70 80 90 100 110 120
VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS HFNVLAFPCS QYGDTESGTS
130 140 150 160 170 180
REIEAFAKSN YGVTFPIFNK IKIMGSEAEP AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR
190 200
FWKPEEPVSD IRKEATTLVR NIILKKRQEL