Q7ZUM8
Gene name |
usp44 (zgc:55661) |
Protein name |
Ubiquitin carboxyl-terminal hydrolase 44 |
Names |
Deubiquitinating enzyme 44, Ubiquitin thioesterase 44, Ubiquitin-specific-processing protease 44 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:393227 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7ZUM8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7ZUM8-F1 | Predicted | AlphaFoldDB |
No variants for Q7ZUM8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7ZUM8 | |||||
No associated diseases with Q7ZUM8
5 regional properties for Q7ZUM8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | 295 - 681 | IPR001394 |
| domain | Zinc finger, UBP-type | 2 - 99 | IPR001607 |
| conserved_site | Ubiquitin specific protease, conserved site | 296 - 311 | IPR018200-1 |
| conserved_site | Ubiquitin specific protease, conserved site | 625 - 643 | IPR018200-2 |
| domain | Ubiquitin specific protease domain | 295 - 684 | IPR028889 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| central nervous system morphogenesis | The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| cranial skeletal system development | The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. |
| negative regulation of ubiquitin protein ligase activity | Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRCKHVGRL | RLAQDHSILN | PQKWHCVDCN | TTESVWACLS | CSHVACGRYI | EEHALQHFKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QHHPLALEVN | ELYVYCYLCD | DYVLNDNATG | DLKLLRSTLS | AIKSQCYEVT | TRSGRTLRSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SANGDQLSPS | TQELQLRDED | RMFTALWHRR | RALIGRLFRL | WFAQTERGKK | RLEEERQQEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEERKREARE | RRRQLKRQLK | EELESAPPRK | SHRIRRQSLK | ATSVKPARAP | AKSTKSVRRR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SAPARVSTPT | PRTPRERTPQ | QRPRPQAKAK | RPQAPPSKTG | DSPVKRRPTV | TPGVTGLRNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GNTCYMNSIL | QVLSHLHVFR | ECFLRLDLNQ | ALELLASAVS | RKLGLSAQRV | IQPKGLNQGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLSGGASRSR | NMELIQPKEP | SSKHISLCHE | LHTLFPVMWS | GKWALVSPFA | MLHSVWQLIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AFRGYAQQDA | QEFLCELLDK | VQHELERTRT | LTPATVPANQ | RRLIKQVLSV | VNTIFHGQLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SQVRCLACDH | RSNTIEPFWD | LSLEFPERYH | SNSKDAAQVP | CGLTEMLAKF | TETEALEGAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YACDYCNNKR | RRFCSKQVVL | TEAQKQLMVH | KLPHVLRLHL | KRFRWSGRNH | REKIGVHVQF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EQELNMEPYC | CKDSGNLPHP | QHFLYQLSAV | VMHHGKGFGS | GHYTAFCYNT | EGGFWVHCND |
| 670 | 680 | 690 | |||
| SKLSVCAVEE | VCKAQAYILF | YTQRNAQDKS | KESDL |