Q7ZTS4

PR
Gene name
krt18
Protein name
Keratin, type I cytoskeletal 18
Names
Cytokeratin-18, CK-18, Dorsal aorta proneprin kinesin-1, DreK18, Keratin-18, K18
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:352912
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZTS4

Entry ID Method Resolution Chain Position Source
AF-Q7ZTS4-F1 Predicted AlphaFoldDB

No variants for Q7ZTS4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZTS4

No associated diseases with Q7ZTS4

2 regional properties for Q7ZTS4

Type Name Position InterPro Accession
conserved_site Intermediate filament protein, conserved site 381 - 389 IPR018039
domain Intermediate filament, rod domain 83 - 395 IPR039008

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

1 GO annotations of biological process

Name Definition
intermediate filament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05783 KRT18 Keratin, type I cytoskeletal 18 Homo sapiens (Human) PR
Q6P864 krt18 Keratin, type I cytoskeletal 18 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSLRTSYSVR SSTSQVPVSQ VSIKRTTNVP TYRAASIYGG AGGQGTRISS ASYSGVRSGL
70 80 90 100 110 120
GVPSMSSSIQ VSASGSTGEI MGNEKMAMQN LNDRLASYLE KVRILEQANS KLELKIREAL
130 140 150 160 170 180
EKRGPDVHDY SRFQPIVDEL RKKIFDATTN NARLVLQIDN ARLAADDFRV KYESELSIRQ
190 200 210 220 230 240
GVEADITGLR KVIDDTNLNR MNLESEIEAL KEELIFLKKN HDNEVMELRN QISQSGVQVD
250 260 270 280 290 300
VDAPKGQDLS QIMEEIRAKY EKMALKNQEE LKAWHESQIT EVQVQVTQNT EALQGARSEV
310 320 330 340 350 360
NELRRQIQTL EIELESQKNL KGSLEGTLRD TEMRYNMEIE NLNTIILQLE AELTQLRGNI
370 380 390 400 410 420
QHQTQEYEAL LNIKMKLEAE IATYRRLLDG GDFKLQDALE EQKKVKVMTV TQTLVDGKVV
430
SSSTETKERK L