Q7ZT46
Gene name |
gins2 (psf2) |
Protein name |
DNA replication complex GINS protein PSF2 |
Names |
GINS complex subunit 2 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:444053 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q7ZT46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8Q6O | EM | 314 A | H/N | 1-185 | PDB |
| AF-Q7ZT46-F1 | Predicted | AlphaFoldDB |
No variants for Q7ZT46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7ZT46 | |||||
No associated diseases with Q7ZT46
1 regional properties for Q7ZT46
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GINS subunit, domain A | 42 - 153 | IPR021151 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| GINS complex | A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| DNA strand elongation involved in DNA replication | The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. |
| regulation of DNA-templated transcription elongation | Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDASEVEFLA | EKEQVTVIPN | FSLDKVYLIG | GDLGPFNPSL | PVEVPLWLAI | NLKQRQKCRI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPPEWMDVEK | LEAIRDQERR | EETFTPMPSP | YYMELTKLLL | NHAADNIPKA | DEIRTLVKDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WDTRIAKLRL | SADSFVKGQE | AHAKLDNLTL | MEINTIGTFF | TESLNHMYKL | RTSLQNPEEG |
| QSQDY |