AiPD: Autoinhibited Protein Database

Q7Z7C7

Gene name	STRA8
Protein name	Stimulated by retinoic acid gene 8 protein homolog
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:346673
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-87 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q7Z7C7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7Z7C7-F1	Predicted				AlphaFoldDB

125 variants for Q7Z7C7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1208099371 CA369343386	4	I>T		No	ClinGen gnomAD
CA4496901 rs765127846	6	V>A		No	ClinGen ExAC TOPMed gnomAD
CA369343414 rs765127846	6	V>G		No	ClinGen ExAC TOPMed gnomAD
CA369343429 rs1585461757	7	D>E		No	ClinGen Ensembl
rs752702647 CA4496902	7	D>Y		No	ClinGen ExAC gnomAD
CA167041213 rs953698195	8	K>E		No	ClinGen TOPMed gnomAD
CA369343443 COSM1548646 rs1312203249	8	K>N	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs762330819 CA4496903	9	I>N		No	ClinGen ExAC TOPMed gnomAD
rs762330819 CA4496904	9	I>T		No	ClinGen ExAC TOPMed gnomAD
rs773111637 CA4496905	10	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1274163833 CA369343501	12	F>S		No	ClinGen TOPMed
CA369343529 rs1235597855	13	N>H		No	ClinGen TOPMed
rs1210944974 CA369343582	15	E>G		No	ClinGen gnomAD
rs781689842 CA4496907	16	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1585461794 CA369343604	16	I>S		No	ClinGen Ensembl
TCGA novel	19	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	20	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA167041238 rs900991954	20	Q>R		No	ClinGen TOPMed gnomAD
CA4496926 rs762963765	21	L>F		No	ClinGen ExAC TOPMed gnomAD
rs763501090 CA4496927	22	I>L		No	ClinGen ExAC TOPMed
VAR_081144	25	T>I	found in patients with non-obstructive azoospermia; unknown pathological significance [UniProt]	No	UniProt
rs751184856 CA4496928	25	T>N		No	ClinGen ExAC gnomAD
TCGA novel	27	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369346821 rs1471465556	29	N>K		No	ClinGen gnomAD
CA4496929 rs761530053	30	S>R		No	ClinGen ExAC gnomAD
CA4496930 rs767331592	31	N>H		No	ClinGen ExAC gnomAD
rs1457128949 CA369346894	32	P>L		No	ClinGen gnomAD
TCGA novel	33	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs536092049 CA4496932	33	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA369346954 rs1409913869	34	D>N		No	ClinGen gnomAD
CA4496933 rs780468268	36	A>V		No	ClinGen ExAC gnomAD
CA4496936 rs148605566	38	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369347105 rs1585469457	40	L>M		No	ClinGen Ensembl
rs748266573 CA4496937	41	P>L		No	ClinGen ExAC gnomAD
CA4496938 rs772260341	42	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4496939 rs777932586	43	Q>P		No	ClinGen ExAC gnomAD
rs747258828 CA4496940	46	E>D		No	ClinGen ExAC gnomAD
rs1250924112 CA369347352	48	E>A		No	ClinGen gnomAD
rs1205996229 CA369347345	48	E>K		No	ClinGen gnomAD
rs776940808 CA4496943	50	R>L		No	ClinGen ExAC TOPMed gnomAD
rs776940808 CA4496942	50	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs769415938 CA4496941	50	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA369347485 rs1585469518	51	V>G		No	ClinGen Ensembl
rs1485511380 CA369347544	52	A>G		No	ClinGen TOPMed
rs1485511380 CA369347547	52	A>V		No	ClinGen TOPMed
CA167051747 rs762351840 COSM452396	53	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs773972478 CA4496945 COSM1448251	53	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs373793185 CA4496948	55	R>P		No	ClinGen ExAC TOPMed gnomAD
rs373793185 CA4496947	55	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs765416789 CA4496946	55	R>W		No	ClinGen ExAC TOPMed gnomAD
CA369347675 rs1370458408	57	S>P		No	ClinGen gnomAD
CA369347704 rs1585469589	58	Q>R		No	ClinGen Ensembl
rs10230595 CA4496950	60	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4496951 rs754296969	60	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1585469615 CA369347803	61	H>P		No	ClinGen Ensembl
CA4496952 rs369945906	62	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA369347824 rs369945906	62	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs765782279 CA4496953	62	R>Q		No	ClinGen ExAC gnomAD
CA369347899 rs1490885608	65	L>Q		No	ClinGen gnomAD
rs1344611497 CA369347907	66	A>T		No	ClinGen gnomAD
CA369347932 rs1229205307	66	A>V		No	ClinGen TOPMed gnomAD
CA4496955 rs753234386	67	A>E		No	ClinGen ExAC TOPMed gnomAD
CA4496954 rs753234386	67	A>G		No	ClinGen ExAC TOPMed gnomAD
CA4496956 rs753234386	67	A>V		No	ClinGen ExAC TOPMed gnomAD
CA369347996 rs1395296796	69	F>V		No	ClinGen TOPMed
CA4496959 rs779678974	70	N>S		No	ClinGen ExAC TOPMed gnomAD
rs749153982 CA4496960	71	N>D		No	ClinGen ExAC gnomAD
rs1006494430 CA369348177	75	T>A		No	ClinGen TOPMed gnomAD
rs1006494430 CA167051790	75	T>P		No	ClinGen TOPMed gnomAD
rs12669242 CA167051796	76	V>E		No	ClinGen Ensembl
CA369348198 rs1475181144	76	V>M		No	ClinGen TOPMed
rs1562969364 CA369348218	77	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA369348308 rs1167414523	81	D>H		No	ClinGen gnomAD
CA167051809 rs1016381200	81	D>V		No	ClinGen TOPMed gnomAD
rs1415696192 CA369348381	83	I>L		No	ClinGen gnomAD
CA4496964 rs771653049	83	I>T		No	ClinGen ExAC TOPMed gnomAD
rs959564655 CA167051810	85	S>*		No	ClinGen TOPMed
rs1196670380 CA369348517	86	K>R		No	ClinGen TOPMed
rs1290153678 COSM204439 CA369349031	87	W>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs746579673 CA4496984	89	V>G		No	ClinGen ExAC gnomAD
rs1207912588 CA369349194	91	N>S		No	ClinGen gnomAD
rs1562970008 CA369349286	93	A>E		No	ClinGen Ensembl
rs969145646 CA167053037	94	K>E		No	ClinGen TOPMed gnomAD
rs761401922 CA167053059	94	K>R		No	ClinGen Ensembl
CA4496985 rs770370441 CA4496986	95	S>R		No	ClinGen ExAC gnomAD
rs1221626102 CA369349395	96	H>R		No	ClinGen gnomAD
rs770128779 CA4496988	100	L>R		No	ClinGen ExAC
CA4496989 rs775897039	101	E>*		No	ClinGen ExAC gnomAD
CA167053118 rs779662938	101	E>G		No	ClinGen Ensembl
rs181931268 CA4496990	102	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4496991 rs764707502	102	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA4496992 rs752025503	103	T>S		No	ClinGen ExAC gnomAD
rs1158375165 CA369349599	104	L>P		No	ClinGen gnomAD
CA369349683 rs1562970069	109	K>T		No	ClinGen Ensembl
TCGA novel	111	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1286356263 CA369349805	114	F>L		No	ClinGen TOPMed
CA369349839 rs1448483018	116	L>Q		No	ClinGen gnomAD
rs1283194377 CA369349851	117	E>G		No	ClinGen TOPMed gnomAD
rs760950896 CA4497017	125	E>K		No	ClinGen ExAC TOPMed gnomAD
CA369349965 rs760950896	125	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA369350000 rs1274784358	127	V>F		No	ClinGen gnomAD
CA4497018 rs201416012	132	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA369350110 rs1249041346	134	M>R		No	ClinGen gnomAD
CA4497019 rs754136315	136	S>C		No	ClinGen ExAC gnomAD
TCGA novel	137	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4497020 rs528155972	138	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559062896 CA167054627	141	F>L		No	ClinGen Ensembl
CA369351358 rs1585473802	143	Q>E		No	ClinGen Ensembl
CA369351391 rs1383820062	145	G>C		No	ClinGen TOPMed gnomAD
CA4497039 rs543917338	145	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA369351409 rs1302821836	146	S>C		No	ClinGen gnomAD
CA369351436 rs1403978636	148	P>T		No	ClinGen TOPMed gnomAD
rs763215346	155	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	202	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	204	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	208	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	215	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1430655522	229	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	234	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355302246	264	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	294	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1363088441	299	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	310	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317444089	323	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs771273096	327	D>N	Variant assessed as Somatic; 5.105e-05 impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q7Z7C7

1 regional properties for Q7Z7C7

Type	Name	Position	InterPro Accession
domain	DNA replication/recombination mediator RecO, N-terminal	44 - 116	IPR022572

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Shuttles between nucleus and cytoplasm Nuclear export is XPO1-dependent
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

7 GO annotations of biological process

Name	Definition
activation of meiosis	Any process that starts the inactive process of meiosis.
cellular response to retinoic acid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
oogenesis	The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MGKIDVDKIL	FFNQEIRLWQ	LIMATPEENS	NPHDRATPQL	PAQLQELEHR	VARRRLSQAR
70	80	90	100	110	120
HRATLAALFN	NLRKTVYSQS	DLIASKWQVL	NKAKSHIPEL	EQTLDNLLKL	KASFNLEDGH
130	140	150	160	170	180
ASSLEEVKKE	YASMYSGNDS	FPQNGSSPWY	LNFYKQTMDL	LTGSGIITPQ	EAALPIVSAA
190	200	210	220	230	240
ISHLWQNLSE	ERKASLRQAW	AQKHRGPATL	AEACREPACA	EGSVKDSGVD	SQGASCSLVS
250	260	270	280	290	300
TPEEILFEDA	FDVASFLDKS	EVPSTSSSSS	VLASCNPENP	EEKFQLYMQI	INFFKGLSCA
310	320
NTQVKQEASF	PVDEEMIMLQ	CTETFDDEDL