AiPD: Autoinhibited Protein Database

Q7Z628

Gene name	NET1 (ARHGEF8)
Protein name	Neuroepithelial cell-transforming gene 1 protein
Names	Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10276
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-175 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-175 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q7Z628

Entry ID	Method	Resolution	Chain	Position	Source
3EO2	X-ray	260 A	A	161-373	PDB
4XH9	X-ray	200 A	A/D	149-501	PDB
AF-Q7Z628-F1	Predicted				AlphaFoldDB

473 variants for Q7Z628

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA375892427 rs1554818513 RCV000577843	166	E>D	Ependymoma [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA204082 rs796052153 RCV000190140	195	L>F	Long QT syndrome [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs775840996 CA5392230	2	E>D		No	ClinGen ExAC gnomAD
TCGA novel	2	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375900782 rs1461138277	3	P>L		No	ClinGen gnomAD
rs1371010835 CA375900772	3	P>T		No	ClinGen gnomAD
CA375900827 rs1449724074	7	A>T		No	ClinGen TOPMed gnomAD
CA375900831 rs1401074413	7	A>V		No	ClinGen TOPMed
rs1324464509 CA375900839	8	Q>P		No	ClinGen gnomAD
CA375900875 rs1303435307	11	P>L		No	ClinGen TOPMed gnomAD
rs1387402474 CA375900873	11	P>S		No	ClinGen gnomAD
rs1161682058 CA375900880	12	R>*		No	ClinGen TOPMed gnomAD
CA202194191 rs982596347	12	R>Q		No	ClinGen TOPMed gnomAD
rs1165143144 CA375900889	13	P>A		No	ClinGen TOPMed
rs763284083 CA5392231	13	P>Q		No	ClinGen ExAC gnomAD
CA202194227 rs1015542810	14	R>P		No	ClinGen TOPMed gnomAD
CA202194225 rs1015542810	14	R>Q		No	ClinGen TOPMed gnomAD
CA202194216 rs1045722841	14	R>W		No	ClinGen TOPMed gnomAD
CA375900920 rs1428969000	16	R>Q		No	ClinGen TOPMed
rs774046393 CA5392233	17	S>R		No	ClinGen ExAC TOPMed gnomAD
CA5392232 rs763917013	17	S>R		No	ClinGen ExAC gnomAD
rs1192460303 CA375900940	18	R>C		No	ClinGen gnomAD
rs1258973960 CA375900944	18	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1258973960 CA375900947	18	R>L		No	ClinGen TOPMed gnomAD
rs761761946 CA5392234	19	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1313290331 CA375900971	21	S>A		No	ClinGen TOPMed gnomAD
rs1193918004 CA375900974	21	S>F		No	ClinGen gnomAD
CA375900989 rs1219623712	24	S>G		No	ClinGen TOPMed
rs544068938 CA5392235	25	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1588419499 CA375901029	27	G>E		No	ClinGen Ensembl
rs1163464412 CA375901023	27	G>R		No	ClinGen TOPMed gnomAD
rs750418616 CA5392236	28	A>E		No	ClinGen ExAC TOPMed gnomAD
rs750418616 CA375901039	28	A>G		No	ClinGen ExAC TOPMed gnomAD
CA375901052 rs1329421015	29	T>M		No	ClinGen TOPMed gnomAD
rs991902356 CA202194270	30	G>E		No	ClinGen Ensembl
rs1356093770 CA375901086	33	A>T		No	ClinGen TOPMed
rs1208890071 CA375901095	33	A>V		No	ClinGen gnomAD
CA5392240 rs754654538	34	D>E		No	ClinGen ExAC gnomAD
rs1427861719 CA375901104	34	D>Y		No	ClinGen TOPMed
rs1483910219 CA375901147	37	G>A		No	ClinGen TOPMed gnomAD
CA375901145 rs1483910219	37	G>E		No	ClinGen TOPMed gnomAD
TCGA novel	37	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1483910219 CA375901149	37	G>V		No	ClinGen TOPMed gnomAD
CA375901143 rs1342199935	37	G>W		No	ClinGen gnomAD
CA5392243 rs757679685	39	E>Q		No	ClinGen ExAC gnomAD
rs781545991 CA5392244	40	L>V		No	ClinGen ExAC gnomAD
CA375901183 rs1252582870	41	D>N		No	ClinGen TOPMed
CA202194323 rs950242118	42	G>E		No	ClinGen TOPMed gnomAD
rs1471845223 CA375901199	42	G>R		No	ClinGen TOPMed gnomAD
rs950242118 CA375901205	42	G>V		No	ClinGen TOPMed gnomAD
CA375901202 rs1471845223	42	G>W		No	ClinGen TOPMed gnomAD
CA5392246 rs769935178	43	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1368211231 CA375901208	43	R>K		No	ClinGen TOPMed
rs1459502842 CA375888540	43	R>S		No	ClinGen Ensembl
rs1407838605 CA375888554	45	S>F		No	ClinGen gnomAD
CA5392261 rs752461321	46	L>P		No	ClinGen ExAC gnomAD
CA375888562 rs374584284	47	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392262 rs374584284	47	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA375888561 rs1159337301	47	R>W		No	ClinGen gnomAD
CA5392263 rs368254317	49	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs990353482 CA375888583	50	S>R		No	ClinGen TOPMed gnomAD
CA5392264 rs746311540	53	T>A		No	ClinGen ExAC gnomAD
rs756721974 CA5392265	53	T>I		No	ClinGen ExAC gnomAD
rs749357959 CA5392267	55	L>S		No	ClinGen ExAC gnomAD
CA202210777 rs921086882	58	G>S		No	ClinGen TOPMed
CA375888639 rs1588426315	60	N>H		No	ClinGen Ensembl
CA5392269 rs779002760	60	N>I		No	ClinGen ExAC TOPMed gnomAD
rs938984799 CA375888643	60	N>K		No	ClinGen TOPMed gnomAD
CA5392270 rs779002760	60	N>S		No	ClinGen ExAC TOPMed gnomAD
CA202210796 rs1036063177	62	D>E		No	ClinGen TOPMed gnomAD
CA5392271 rs771709270	62	D>G		No	ClinGen ExAC gnomAD
CA5392272 rs773087864	64	T>P		No	ClinGen ExAC gnomAD
rs1160082298 CA375889027	66	K>E		No	ClinGen TOPMed
COSM918880 rs776534266 CA5392294	69	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs201465257 CA5392295	69	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs201465257 CA375889078	69	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392296 rs375050925	70	R>S		No	ClinGen ESP ExAC gnomAD
CA5392297 rs775097623	72	K>E		No	ClinGen ExAC gnomAD
CA5392299 rs763782441	73	D>N		No	ClinGen ExAC gnomAD
CA5392301 rs199764175	76	V>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5392300 rs751299175	76	V>I		No	ClinGen ExAC gnomAD
rs766910511 CA5392302	80	S>R		No	ClinGen ExAC gnomAD
rs754342915 CA375889236	81	S>R		No	ClinGen ExAC gnomAD
CA375889279 rs1255515255	85	K>E		No	ClinGen TOPMed
rs778806339 CA5392305	85	K>T		No	ClinGen ExAC TOPMed
CA5392362 rs775748520	86	E>D		No	ClinGen ExAC gnomAD
rs1200544182 CA375891565	86	E>K		No	ClinGen gnomAD
rs559018095 CA5392364	88	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs774878618 CA5392365	88	S>R		No	ClinGen ExAC TOPMed
rs376079720 CA5392366	92	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA202222937 rs267602526	93	R>*		No	ClinGen gnomAD
CA375891617 rs1219783347	94	P>S		No	ClinGen gnomAD
rs750603546 CA5392368	97	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375891633 rs750603546	97	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5392369 rs368625548	97	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA375891647 rs1338208554 COSM427672 COSM427671	99	T>M	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs754857685 CA5392372	100	S>C		No	ClinGen ExAC gnomAD
CA375891653 rs1319933132	101	L>V		No	ClinGen gnomAD
rs752738079 CA5392374	103	N>K		No	ClinGen ExAC
rs1451368480 CA375891699	108	V>I		No	ClinGen gnomAD
rs757921645 CA5392376	110	N>H		No	ClinGen ExAC gnomAD
TCGA novel	112	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375891735 rs1211322981	113	V>A		No	ClinGen TOPMed gnomAD
CA375891732 rs1256039366	113	V>L		No	ClinGen Ensembl
rs770943371 CA5392378	115	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5392379 rs758032740	115	R>H		No	ClinGen ExAC gnomAD
rs1288843575 CA375891768	117	G>D		No	ClinGen TOPMed
CA202222977 rs1015944287	120	I>V		No	ClinGen TOPMed
rs1487034115 CA375891963 COSM179204 COSM179203	122	S>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA5392392 rs754177120	123	F>C		No	ClinGen ExAC gnomAD
rs1424863316 CA375891998	126	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5392394 rs146200933	126	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392395 rs146200933	126	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA375892002 rs146200933	126	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs763610743 CA5392397	127	G>D		No	ClinGen ExAC gnomAD
rs139203225 CA5392396	127	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs756832701 CA202223134	128	D>H		No	ClinGen ExAC gnomAD
CA5392398 rs756832701	128	D>N		No	ClinGen ExAC gnomAD
CA5392399 rs756832491	128	D>V		No	ClinGen ExAC gnomAD
rs780704844 CA5392400	129	H>R		No	ClinGen ExAC gnomAD
rs1588439755 CA375892041	131	S>P		No	ClinGen Ensembl
CA202223150 rs374406538	133	A>G		No	ClinGen Ensembl
TCGA novel	133	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392402 rs755279200	134	S>F		No	ClinGen ExAC TOPMed gnomAD
rs531210844 CA202223156	136	Q>P		No	ClinGen 1000Genomes
CA5392403 rs149871083	137	K>R		No	ClinGen ESP ExAC gnomAD
CA5392404 rs748617913	138	F>L		No	ClinGen ExAC gnomAD
rs772482746 CA375892150	141	R>G		No	ClinGen ExAC TOPMed gnomAD
rs773822256 CA5392406	141	R>S		No	ClinGen ExAC gnomAD
CA375892171 rs1310025485	143	T>A		No	ClinGen TOPMed gnomAD
rs1588439789 CA375892185	144	V>A		No	ClinGen Ensembl
CA202223175 rs564198399	146	T>I		No	ClinGen Ensembl
CA375892204 rs564198399	146	T>K		No	ClinGen Ensembl
CA375892196 rs1588439795	146	T>P		No	ClinGen Ensembl
CA5392409 rs776932264	147	P>R		No	ClinGen ExAC gnomAD
rs926410877 CA202223177	147	P>S		No	ClinGen Ensembl
CA5392412 rs775446522	148	A>S		No	ClinGen ExAC TOPMed gnomAD
rs775446522 CA5392413	148	A>T		No	ClinGen ExAC TOPMed gnomAD
CA375892229 rs1185961933	149	K>R		No	ClinGen gnomAD
CA5392414 rs552295716	151	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA375892247 rs552295716	151	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs751581044 CA5392415	152	S>N		No	ClinGen ExAC gnomAD
CA5392417 rs570787226	159	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	160	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375892362 rs1175112861	161	D>G		No	ClinGen TOPMed gnomAD
rs1412920656 CA375892358	161	D>N		No	ClinGen gnomAD
rs1359515175 CA375892381	163	T>A		No	ClinGen gnomAD
CA202223218 rs572860536 CA375892390	164	M>L		No	ClinGen TOPMed
CA5392418 rs760269274	164	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375892407 rs1588439862	165	K>T		No	ClinGen Ensembl
rs755797607 CA375892441	168	L>F		No	ClinGen ExAC TOPMed gnomAD
rs755797607 CA5392419	168	L>V		No	ClinGen ExAC TOPMed gnomAD
CA202223222 rs77554069	170	T>A		No	ClinGen ESP TOPMed
rs1446909061 CA375892462	170	T>I		No	ClinGen gnomAD
rs1564468048 CA375892466	171	R>K		No	ClinGen Ensembl
CA5392421 rs748493518	172	E>K		No	ClinGen ExAC gnomAD
rs1588439889 CA375892490	173	I>F		No	ClinGen Ensembl
TCGA novel	174	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392424 rs747561109	175	R>Q		No	ClinGen ExAC gnomAD
CA5392423 COSM1135023 COSM1135024 rs778125606	175	R>W	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5392425 rs770846739	176	Q>H		No	ClinGen ExAC gnomAD
CA375892527 rs1210653803	177	E>K		No	ClinGen TOPMed
CA375892585 rs1177007720	178	A>V		No	ClinGen TOPMed
TCGA novel	179	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392443 rs781776606	180	Y>C		No	ClinGen ExAC gnomAD
rs369746605 CA5392444	182	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1469894849 CA375892624	182	M>V		No	ClinGen TOPMed
rs373461269 CA5392445	184	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	184	R>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377267362 CA375892648	184	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs377267362 CA5392446	184	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392447 rs749539181	185	G>A		No	ClinGen ExAC gnomAD
CA375892656 rs749539181	185	G>V		No	ClinGen ExAC gnomAD
CA5392448 rs768271056	187	Q>*		No	ClinGen ExAC gnomAD
CA202223451 rs1033527845	187	Q>R		No	ClinGen Ensembl
rs1404266358 CA375892678	188	D>N		No	ClinGen gnomAD
rs200860140 CA202223456	190	I>T		No	ClinGen TOPMed gnomAD
CA375892722 rs1209462563	191	E>D		No	ClinGen TOPMed
rs1287651014 CA375892755	194	K>R		No	ClinGen TOPMed
rs370808971 CA5392450	197	R>G		No	ClinGen ESP ExAC gnomAD
rs4567355 CA375892859 CA375892857	200	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756205462 CA5392464	201	H>R		No	ClinGen ExAC gnomAD
VAR_035972	202	D>N	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
rs894380059 CA202223637	204	M>T		No	ClinGen TOPMed
CA375892956 rs1385079822	209	I>T		No	ClinGen gnomAD
rs768947309 CA5392467	211	S>A		No	ClinGen ExAC gnomAD
rs1252124237 CA375893054	217	H>Y		No	ClinGen TOPMed
CA375893069 rs1206680688	218	I>T		No	ClinGen gnomAD
rs779055914 CA5392468	218	I>V		No	ClinGen ExAC gnomAD
CA5392469 rs747947249	219	F>L		No	ClinGen ExAC gnomAD
CA375893081 rs1286430184	219	F>Y		No	ClinGen gnomAD
TCGA novel	220	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375893122 rs1198987509	223	D>Y		No	ClinGen TOPMed
CA5392470 rs771925361	225	Y>C		No	ClinGen ExAC gnomAD
rs771925361 CA375893142	225	Y>S		No	ClinGen ExAC gnomAD
rs746950171 CA5392472	226	I>V		No	ClinGen ExAC gnomAD
rs770384396 CA5392473	227	P>S		No	ClinGen ExAC gnomAD
CA375893176 rs1228145582	229	H>Y		No	ClinGen gnomAD
rs1177412078 CA375893188	230	E>A		No	ClinGen gnomAD
rs1380558860 CA375893195	231	D>N		No	ClinGen gnomAD
CA375893321 rs1475434998	239	A>T		No	ClinGen TOPMed gnomAD
CA5392496 rs372145323	240	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA375893354 rs1393402928	242	P>S		No	ClinGen gnomAD
CA5392499 rs773741515	244	G>E		No	ClinGen ExAC gnomAD
rs766884323 CA5392501	248	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA375893419 rs766884323	248	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA202223892 rs755077949	249	I>M		No	ClinGen ExAC TOPMed gnomAD
rs775310225 CA5392502	249	I>T		No	ClinGen ExAC gnomAD
rs564836015 CA5392504	251	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5392505 rs752870844	252	I>T		No	ClinGen ExAC gnomAD
rs1397098323 CA375893485	254	V>A		No	ClinGen TOPMed
rs151234884 CA5392507	254	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs151234884 CA5392506	254	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA375893498 rs201881295	255	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA202224332 rs893612064	258	P>L		No	ClinGen Ensembl
rs758204951 CA5392528	259	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5392529 rs750324554	259	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1165670097 CA375893904	261	N>S		No	ClinGen gnomAD
rs995954594 CA202224341	262	A>V		No	ClinGen Ensembl
rs1364186746 CA375893923	264	R>K		No	ClinGen TOPMed
rs1286838364 CA375893929	265	G>R		No	ClinGen gnomAD
rs756036110 CA5392530	265	G>V		No	ClinGen ExAC gnomAD
rs1452817963 CA375893940	266	Y>*		No	ClinGen gnomAD
rs61754990 CA5392533	272	A>T		No	ClinGen ExAC gnomAD
TCGA novel	274	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392534 rs778699391	275	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1328399768 CA375894014	278	D>N		No	ClinGen TOPMed
CA375894019 rs1382851060	278	D>V		No	ClinGen gnomAD
CA202224358 rs146985331	279	Q>E		No	ClinGen ESP TOPMed
CA354942 RCV000209865 rs869312683	280	K>R		No	ClinGen ClinVar Ensembl dbSNP
rs371688080 CA5392535	281	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392536 rs771282421	283	D>H		No	ClinGen ExAC gnomAD
rs771282421 CA375894052	283	D>Y		No	ClinGen ExAC gnomAD
rs1215521207 CA375894062	284	P>L		No	ClinGen gnomAD
CA5392537 rs776894777	285	R>G		No	ClinGen ExAC gnomAD
rs759987982 CA5392538	287	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs759987982 CA202224399	287	Q>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	288	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392539 rs770265697	292	R>L		No	ClinGen ExAC gnomAD
CA5392540 rs770265697	292	R>Q		No	ClinGen ExAC gnomAD
CA202224430 rs931423338	293	C>R		No	ClinGen TOPMed
rs1445287809 CA375894120	293	C>W		No	ClinGen gnomAD
TCGA novel	294	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	294	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751723448 CA5392543	295	E>D		No	ClinGen ExAC gnomAD
CA5392542 rs764163990	295	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1343012741 CA375894132	295	E>V		No	ClinGen TOPMed gnomAD
CA202224434 rs911304753	296	S>F		No	ClinGen TOPMed
rs761963072 CA5392544	297	P>A		No	ClinGen ExAC gnomAD
CA5392545 rs767303188	299	S>G		No	ClinGen ExAC gnomAD
rs962117665 CA375894160	300	R>*		No	ClinGen gnomAD
CA5392546 rs750153130	300	R>Q		No	ClinGen ExAC gnomAD
rs1406672362 CA375894169	301	K>N		No	ClinGen gnomAD
CA5392547 rs755984653	302	L>R		No	ClinGen ExAC gnomAD
CA375894172 rs1454151007	302	L>V		No	ClinGen gnomAD
CA375894185 rs1223977566	304	L>F		No	ClinGen gnomAD
CA5392548 rs750390330	305	W>C		No	ClinGen ExAC gnomAD
CA375894211 rs1272407678	307	F>L		No	ClinGen TOPMed
rs753890242 CA5392549	310	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375894228 rs1319072958	310	I>V		No	ClinGen gnomAD
rs1263085638 CA375894238	312	R>*		No	ClinGen gnomAD
CA202224472 rs994565979	312	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs754467713 CA5392550	313	S>N		No	ClinGen ExAC gnomAD
CA375894252 rs1205204380	314	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5392551 rs778576326	315	L>P		No	ClinGen ExAC gnomAD
rs1588441267 CA375894256	315	L>V		No	ClinGen Ensembl
TCGA novel	320	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	322	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392554 rs777534435	323	K>R		No	ClinGen ExAC gnomAD
rs1409956306 CA375894322	325	I>F		No	ClinGen gnomAD
TCGA novel	326	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392556 rs746208601	326	L>I		No	ClinGen ExAC TOPMed gnomAD
CA5392555 rs746208601	326	L>V		No	ClinGen ExAC TOPMed gnomAD
CA5392557 rs377523635	331	K>E		No	ClinGen ESP ExAC gnomAD
CA375894363 rs1429917139	331	K>R		No	ClinGen gnomAD
CA5392558 rs749810077	333	H>L		No	ClinGen ExAC gnomAD
rs1328752255 CA375894405	337	Q>L		No	ClinGen TOPMed gnomAD
CA5392560 rs774324552	340	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs545979388 CA5392561	341	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA5392572 rs746680053	343	I>V		No	ClinGen ExAC gnomAD
CA5392573 rs756413323	344	L>W		No	ClinGen ExAC gnomAD
CA5392574 rs780419709	348	G>E		No	ClinGen ExAC gnomAD
rs1346509294 CA375894493	349	V>I		No	ClinGen gnomAD
CA5392575 rs749754949	350	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	352	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA202224778 rs201182048	353	I>T		No	ClinGen 1000Genomes
CA375894528 rs1268959924	354	N>T		No	ClinGen gnomAD
rs769120430 CA5392576	357	K>T		No	ClinGen ExAC gnomAD
CA5392577 rs774969026	358	G>R		No	ClinGen ExAC gnomAD
CA5392578 rs748162590	360	S>F		No	ClinGen ExAC gnomAD
COSM3807334 COSM3807333 CA5392580 rs773238555	361	E>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA202224817 rs377334144	362	C>F		No	ClinGen ESP
CA375894580 rs1269379691	362	C>R		No	ClinGen TOPMed gnomAD
rs1319588194 CA375894590	363	Q>R		No	ClinGen TOPMed
CA375894599 rs1191176049	364	Y>F		No	ClinGen gnomAD
rs766223722 CA5392582	365	Y>N		No	ClinGen ExAC gnomAD
CA5392584 rs780878115	367	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5392588 rs763676175	373	D>G		No	ClinGen ExAC gnomAD
rs572187183 CA5392587	373	D>N		No	ClinGen ExAC gnomAD
CA375894680 rs1173804499	376	Q>*		No	ClinGen gnomAD
rs1316600418 CA375894722	382	E>K		No	ClinGen gnomAD
CA5392590 rs756934022	383	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5392593 rs755393221	385	K>E		No	ClinGen ExAC
CA375894748 rs1564469415	385	K>N		No	ClinGen Ensembl
rs1380631661 CA375894759	387	L>P		No	ClinGen gnomAD
CA375894778 rs1306668516	390	H>R		No	ClinGen gnomAD
CA5392596 rs150393153	394	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141666952 CA5392595	394	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392597 rs777927954	398	G>R		No	ClinGen ExAC gnomAD
CA5392598 rs371604395	399	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	404	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375894890 rs1160618737	405	L>V		No	ClinGen gnomAD
rs1427822887 CA375894899	406	F>C		No	ClinGen gnomAD
rs775386441 CA5392620	407	Q>H		No	ClinGen ExAC gnomAD
CA5392619 rs746108427	407	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs746108427 CA5392618	407	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA5392621 rs762696046	409	I>L		No	ClinGen ExAC gnomAD
rs1389938583 CA375894920	409	I>M		No	ClinGen gnomAD
rs1195033836 CA375894918	409	I>T		No	ClinGen TOPMed gnomAD
CA375894929 rs1336535761	411	V>L		No	ClinGen gnomAD
rs199808307 CA202225337	414	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs199808307 CA5392623	414	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA375894951 rs1408725996	415	P>T		No	ClinGen TOPMed
CA5392625 rs149569698	416	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA375894955 rs149569698	416	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA375894961 rs1224038057	417	T>A		No	ClinGen gnomAD
CA5392626 RCV000959705 rs34658946 VAR_051982	417	T>I		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs34658946 CA5392627	417	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371131105 CA5392628	418	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs758752089 CA5392630	420	E>K		No	ClinGen ExAC gnomAD
CA5392632 rs752119110	421	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5392631 rs139037982	421	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA202225377 rs901120132	423	S>F		No	ClinGen TOPMed
CA591842167 rs1480435073	424	Y>*		No	ClinGen gnomAD
rs1475584668 CA375895264	425	Q>L		No	ClinGen TOPMed
rs746037180 CA5392635	427	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs746037180 CA375895286	427	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA5392637 rs780188577	428	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5392636 rs756328814	428	R>W		No	ClinGen ExAC gnomAD
CA375895302 rs1483112892	429	Q>K		No	ClinGen TOPMed
rs1462870235 CA375895322	430	P>S		No	ClinGen gnomAD
CA5392638 rs540059620 COSM212015 COSM212014	431	I>V	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs969922933 CA202225420	434	Q>R		No	ClinGen gnomAD
CA375895391 rs1285144439	435	E>Q		No	ClinGen gnomAD
CA5392640 rs774206420	436	L>V		No	ClinGen ExAC gnomAD
rs1226066671 CA375895422	438	L>I		No	ClinGen gnomAD
rs1341109609 CA375895440	439	E>G		No	ClinGen gnomAD
rs1290102993 CA375895452	440	D>H		No	ClinGen TOPMed gnomAD
rs1290102993 CA375895448	440	D>N		No	ClinGen TOPMed gnomAD
CA5392642 rs146371164	445	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA375895532 rs1200547755	446	V>M		No	ClinGen gnomAD
rs772735811 CA5392643	448	M>K		No	ClinGen ExAC gnomAD
CA5392644 rs772735811	448	M>T		No	ClinGen ExAC gnomAD
rs981110431 CA202225440	450	G>A		No	ClinGen Ensembl
rs766045697 CA5392645	453	R>*		No	ClinGen ExAC gnomAD
CA202225445 rs928258554	453	R>Q		No	ClinGen TOPMed gnomAD
CA5392648 rs764570797	458	N>S		No	ClinGen ExAC gnomAD
CA375895720 rs1304664294	459	S>L		No	ClinGen gnomAD
rs757872779 CA5392650	462	A>T		No	ClinGen ExAC gnomAD
TCGA novel	464	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM262387 COSM262388 rs150542987 CA5392675	469	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA5392676 rs750957300	469	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750957300 CA375895909	469	R>L		No	ClinGen ExAC TOPMed gnomAD
CA202225752 rs373651845	471	H>Y		No	ClinGen ESP
rs1018720035 CA202225755	472	D>A		No	ClinGen Ensembl
CA375895970 rs1466589618	473	P>L		No	ClinGen gnomAD
rs760741100 CA5392677	473	P>S		No	ClinGen ExAC TOPMed gnomAD
rs760741100 CA375895961	473	P>T		No	ClinGen ExAC TOPMed gnomAD
CA202225756 rs975094171	475	P>Q		No	ClinGen TOPMed gnomAD
rs766382399 CA5392678	477	Q>*		No	ClinGen ExAC gnomAD
rs1408111953 CA375896011	477	Q>R		No	ClinGen TOPMed
rs754039301 CA5392679	480	T>I		No	ClinGen ExAC TOPMed gnomAD
CA375896044 rs1165972919	480	T>S		No	ClinGen gnomAD
rs754039301 CA375896050	480	T>S		No	ClinGen ExAC TOPMed gnomAD
CA375896055 rs1405583239	481	L>V		No	ClinGen gnomAD
CA375896062 rs1418315678	482	Q>K		No	ClinGen gnomAD
CA375896080 rs1159480466	483	A>S		No	ClinGen gnomAD
rs374195268 CA5392681	486	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs752463889 CA5392682	487	F>L		No	ClinGen ExAC
CA375896268 rs1322633964	490	Q>P		No	ClinGen gnomAD
TCGA novel	493	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777702059 CA5392684	495	C>R		No	ClinGen ExAC TOPMed gnomAD
CA5392685 rs149676418	497	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs147838790 CA5392687	498	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5392689 rs769549692	499	A>S		No	ClinGen ExAC TOPMed gnomAD
CA202225823 rs1043593176	500	I>F		No	ClinGen TOPMed
CA5392691 rs762261978	502	P>A		No	ClinGen ExAC gnomAD
CA5392692 rs201622703	502	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201622703 CA375896423	502	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201622703 CA202225841	502	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	503	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866502717 CA202225846	503	F>Y		No	ClinGen Ensembl
CA5392694 rs773709899	504	Q>H		No	ClinGen ExAC TOPMed
CA375896451 rs1212280704	504	Q>R		No	ClinGen gnomAD
rs766438612 CA5392696	505	S>L		No	ClinGen ExAC TOPMed gnomAD
CA5392695 rs761104612	505	S>P		No	ClinGen ExAC gnomAD
rs765444267 CA5392699	506	A>S		No	ClinGen ExAC TOPMed gnomAD
rs765444267 CA375896473	506	A>T		No	ClinGen ExAC TOPMed gnomAD
rs758135988 CA5392701	509	P>L		No	ClinGen ExAC gnomAD
CA375896573 rs1462170828	513	Q>H		No	ClinGen TOPMed gnomAD
CA375896577 rs1309091434	514	G>C		No	ClinGen TOPMed gnomAD
rs1352682828 CA375896580	514	G>D		No	ClinGen gnomAD
rs1309091434 CA375896575	514	G>S		No	ClinGen TOPMed gnomAD
rs781241424 CA5392705	516	P>L		No	ClinGen ExAC gnomAD
rs1368836922 CA375896591	517	E>*		No	ClinGen gnomAD
CA375896593 rs1368836922	517	E>K		No	ClinGen gnomAD
CA375896596 rs1485880930	517	E>V		No	ClinGen gnomAD
CA5392707 rs769494085	519	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA375896606 rs1157668334	519	H>Y		No	ClinGen TOPMed
CA375896614 rs1307201123	520	E>G		No	ClinGen TOPMed gnomAD
COSM427675 CA5392709 RCV000948826 rs34821949 COSM427676	520	E>K	breast [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs34821949 CA375896611	520	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5392711 rs201895973	521	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1588442717 CA375896627	522	C>G		No	ClinGen Ensembl
CA5392712 rs761136760	522	C>Y		No	ClinGen ExAC gnomAD
rs374018048 CA5392713	525	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	525	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1588442735 CA375896658	526	H>P		No	ClinGen Ensembl
CA375896662 rs1206789519	527	P>A		No	ClinGen TOPMed
CA5392715 rs759548072	527	P>H		No	ClinGen ExAC TOPMed gnomAD
CA375896664 rs759548072	527	P>L		No	ClinGen ExAC TOPMed gnomAD
rs527266291 CA5392716	529	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs77930344 CA5392717	529	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1170071768 CA375896681	530	R>S		No	ClinGen TOPMed gnomAD
CA375896686 rs1161477456	531	K>T		No	ClinGen gnomAD
rs751290567 CA5392720	535	Q>H		No	ClinGen ExAC gnomAD
rs201555159 CA5392722	536	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs755625540 CA5392724	538	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779732760 CA5392725	540	T>A		No	ClinGen ExAC gnomAD
rs1564470185 CA375896745	541	V>I		No	ClinGen Ensembl
CA5392726 rs748905401	543	S>G		No	ClinGen ExAC TOPMed gnomAD
CA5392727 rs754551039	543	S>R		No	ClinGen ExAC gnomAD
rs1221489341 CA375896768	544	V>A		No	ClinGen gnomAD
CA5392729 rs778674040	545	T>I		No	ClinGen ExAC gnomAD
rs531847425 CA5392730	546	Q>*		No	ClinGen 1000Genomes ExAC
rs151075877 CA5392731	547	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs746400460 CA5392733	549	V>A		No	ClinGen ExAC TOPMed gnomAD
rs746400460 CA202226025	549	V>G		No	ClinGen ExAC TOPMed gnomAD
rs139000528 CA5392735	553	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150193970 CA202226031	553	A>T		No	ClinGen ESP TOPMed gnomAD
CA5392734 rs139000528	553	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM268138 rs763143040 CA375896839 COSM268139	555	R>S	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5392737 rs764210399	556	C>S		No	ClinGen ExAC TOPMed gnomAD
rs761445992 CA5392739	557	G>V		No	ClinGen ExAC TOPMed gnomAD
CA375896856 rs767356420	558	S>C		No	ClinGen ExAC TOPMed gnomAD
rs767356420 CA5392740	558	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1226214091 CA375896860	559	G>D		No	ClinGen TOPMed gnomAD
rs1226214091 CA375896862	559	G>V		No	ClinGen TOPMed gnomAD
CA375896870 rs1295792847	560	M>I		No	ClinGen TOPMed
CA375896863 rs1435907174	560	M>L		No	ClinGen gnomAD
rs1322574540 CA375896881	562	M>V		No	ClinGen gnomAD
rs1380935307 CA375896894	563	A>V		No	ClinGen gnomAD
CA5392742 rs142260154	564	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs55901782 CA202226079	565	D>N		No	ClinGen Ensembl
rs766456457 CA5392743	568	S>T		No	ClinGen ExAC gnomAD
rs753371663 CA5392744	569	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	571	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392745 rs754572273	571	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1283516350 CA375896961	572	H>Q		No	ClinGen gnomAD
TCGA novel	574	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5392746 rs778422389	576	P>L		No	ClinGen ExAC gnomAD
rs1240718633 CA375896989	577	G>S		No	ClinGen gnomAD
rs926523708 CA202226100	579	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs757517284 CA5392748	579	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5392749 rs781572048	581	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5392750 rs746275592	581	A>V		No	ClinGen ExAC TOPMed gnomAD
CA5392752 rs776035764	583	D>A		No	ClinGen ExAC gnomAD
rs1342449461 CA375897059	588	G>D		No	ClinGen TOPMed gnomAD
CA5392754 rs768787790	589	G>V		No	ClinGen ExAC gnomAD
rs149626244 CA5392756	591	R>Q	Variant assessed as Somatic; 5.117e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs138397277 CA5392755	591	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA375897081 rs1322239067	592	K>E		No	ClinGen gnomAD
TCGA novel	593	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q7Z628

No regional properties for Q7Z628

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q7Z628

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

10 GO annotations of biological process

Name	Definition
cellular response to hydrogen peroxide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
cellular response to ionizing radiation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
myoblast migration	The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
positive regulation of Rho protein signal transduction	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NR81	ARHGEF3	Rho guanine nucleotide exchange factor 3	Homo sapiens (Human)	PR

10	20	30	40	50	60
MEPELAAQKQ	PRPRRRSRRA	SGLSTEGATG	PSADTSGSEL	DGRCSLRRGS	SFTFLTPGPN
70	80	90	100	110	120
WDFTLKRKRR	EKDDDVVSLS	SLDLKEPSNK	RVRPLARVTS	LANLISPVRN	GAVRRFGQTI
130	140	150	160	170	180
QSFTLRGDHR	SPASAQKFSS	RSTVPTPAKR	RSSALWSEML	DITMKESLTT	REIRRQEAIY
190	200	210	220	230	240
EMSRGEQDLI	EDLKLARKAY	HDPMLKLSIM	SEEELTHIFG	DLDSYIPLHE	DLLTRIGEAT
250	260	270	280	290	300
KPDGTVEQIG	HILVSWLPRL	NAYRGYCSNQ	LAAKALLDQK	KQDPRVQDFL	QRCLESPFSR
310	320	330	340	350	360
KLDLWSFLDI	PRSRLVKYPL	LLKEILKHTP	KEHPDVQLLE	DAILIIQGVL	SDINLKKGES
370	380	390	400	410	420
ECQYYIDKLE	YLDEKQRDPR	IEASKVLLCH	GELRSKSGHK	LYIFLFQDIL	VLTRPVTRNE
430	440	450	460	470	480
RHSYQVYRQP	IPVQELVLED	LQDGDVRMGG	SFRGAFSNSE	KAKNIFRIRF	HDPSPAQSHT
490	500	510	520	530	540
LQANDVFHKQ	QWFNCIRAAI	APFQSAGSPP	ELQGLPELHE	ECEGNHPSAR	KLTAQRRAST
550	560	570	580	590
VSSVTQVEVD	ENAYRCGSGM	QMAEDSKSLK	THQTQPGIRR	ARDKALSGGK	RKETLV