AiPD: Autoinhibited Protein Database

Q7Z602

Gene name	GPR141 (PGR13)
Protein name	Probable G-protein coupled receptor 141
Names	G-protein coupled receptor PGR13
Species	Homo sapiens (Human)
KEGG Pathway	hsa:353345
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

181-250 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

181-250 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q7Z602

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7Z602-F1	Predicted				AlphaFoldDB

281 variants for Q7Z602

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs750102831 CA4221786	3	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1032909436 CA157554997	5	N>D		No	ClinGen TOPMed
CA4221787 rs755641967	5	N>S		No	ClinGen ExAC gnomAD
rs199643208 CA4221789	6	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199643208 COSM746990 CA367277486	6	T>N	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1583584108 CA367277485	6	T>P		No	ClinGen Ensembl
rs758984161 CA4221790	7	S>A		No	ClinGen ExAC gnomAD
rs377059932 CA4221791	7	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367277500 rs1441329355	9	N>D		No	ClinGen gnomAD
rs1251303605 CA367277509	10	S>F		No	ClinGen TOPMed
rs370251580 CA4221792	10	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA157554998 rs767082752	11	S>P		No	ClinGen gnomAD
rs775684518 CA4221797	13	D>G		No	ClinGen ExAC TOPMed gnomAD
CA4221796 rs141399721	13	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM601167 rs141399721 CA4221795	13	D>Y	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA4221799 rs145307889	14	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145307889 CA157555000	14	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA157554999 rs969080271	14	P>T		No	ClinGen TOPMed
CA4221800 rs774171280	16	V>A		No	ClinGen ExAC gnomAD
CA367277550 rs1250139040	17	T>I		No	ClinGen gnomAD
TCGA novel	17	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1300743026 CA367277553	18	P>H		No	ClinGen TOPMed
rs1300743026 CA367277555	18	P>L		No	ClinGen TOPMed
CA4221801 rs761632116	18	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4221803 rs750043890	19	H>R		No	ClinGen ExAC gnomAD
CA367277574 rs1193164216	21	I>T		No	ClinGen gnomAD
rs925160389 CA157555001	22	S>N		No	ClinGen Ensembl
rs144599078 CA157555002	26	I>V		No	ClinGen ESP
CA157555004 rs981243681	28	L>I		No	ClinGen TOPMed gnomAD
rs758817530 CA4221808	29	I>M		No	ClinGen ExAC
CA4221806 rs373988182	29	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs765775402 CA4221805	29	I>V		No	ClinGen ExAC gnomAD
TCGA novel	30	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367277633 rs1301958927	31	G>R		No	ClinGen TOPMed gnomAD
rs1275107869 CA367277649	33	V>G		No	ClinGen gnomAD
rs1368671907 CA367277651	34	G>R		No	ClinGen gnomAD
CA367277666 COSM3394732 rs1293960204	36	I>T	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs867379731 CA157555006	37	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA367277681 rs1344895218	39	L>I		No	ClinGen gnomAD
TCGA novel	40	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745990029 CA4221815	41	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1489889195 CA367277700	42	L>M		No	ClinGen gnomAD
rs749335333 CA4221816	43	V>L		No	ClinGen ExAC TOPMed gnomAD
CA157555007 rs749335333	43	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA367277713 rs1247526767	44	K>R		No	ClinGen gnomAD
CA367277730 rs1475243184	46	N>S		No	ClinGen gnomAD
CA4221818 rs774302831	47	T>A		No	ClinGen ExAC TOPMed gnomAD
CA367277734 rs774302831	47	T>P		No	ClinGen ExAC TOPMed gnomAD
CA157555008 rs140146180	47	T>S		No	ClinGen ESP TOPMed
rs566037940 CA4221820	48	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs761861224 CA4221819	48	R>W		No	ClinGen ExAC gnomAD
CA4221823 rs760399282	51	T>I		No	ClinGen ExAC gnomAD
COSM746989 rs760399282 CA4221822	51	T>N	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4221824 rs753444243	52	T>I		No	ClinGen ExAC gnomAD
rs1051200252 CA157555010	52	T>P		No	ClinGen TOPMed gnomAD
CA367277765 rs1428259741	53	M>I		No	ClinGen gnomAD
CA4221825 rs759017142	53	M>L		No	ClinGen ExAC TOPMed gnomAD
CA157555011 rs759017142	53	M>V		No	ClinGen ExAC TOPMed gnomAD
CA4221826 rs534808178	54	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs80037837 CA157555012	55	V>G		No	ClinGen Ensembl
CA367277797 rs1562795129	58	L>*		No	ClinGen Ensembl
CA367277810 rs1314970724	60	V>A		No	ClinGen gnomAD
CA367277812 rs1230090119	61	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA367277822 rs1420449141	62	H>R		No	ClinGen TOPMed
CA4221829 rs372117075	63	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4221831 rs750847818	64	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1010134580 CA157555013	66	L>M		No	ClinGen TOPMed gnomAD
rs780257890 CA4221833	68	T>A		No	ClinGen ExAC gnomAD
rs1473772428 CA367277865	69	V>G		No	ClinGen TOPMed gnomAD
rs571386238 CA4221836	70	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4221837 rs150971296	72	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
VAR_074185 rs772202718 CA4221838 COSM1089429	72	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs772202718 CA157555014	72	R>L		No	ClinGen ExAC TOPMed gnomAD
CA367277894 rs1436295272	74	T>I		No	ClinGen gnomAD
CA367277902 rs1438084491	75	Y>*		No	ClinGen TOPMed gnomAD
rs1339223098 CA367277899	75	Y>C		No	ClinGen gnomAD
rs1339223098 CA367277900	75	Y>F		No	ClinGen gnomAD
CA157555016 rs1034108600	78	K>Q		No	ClinGen TOPMed gnomAD
CA4221840 rs760487084	79	K>E		No	ClinGen ExAC
rs1325096796 CA367277939	81	W>*		No	ClinGen TOPMed gnomAD
rs1232527888 CA367277951	82	M>I		No	ClinGen TOPMed
rs1284834288 CA367277946	82	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4221841 rs574260060	85	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1562795340 CA367277973	86	P>S		No	ClinGen Ensembl
CA157555019 COSM1549917 rs984533010	87	F>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA4221842 rs776299996	87	F>Y		No	ClinGen ExAC gnomAD
rs764774782 CA4221844	88	C>*		No	ClinGen ExAC TOPMed gnomAD
CA4221843 rs759162458	88	C>S		No	ClinGen ExAC gnomAD
CA4221846 rs775048159	89	K>I		No	ClinGen ExAC TOPMed gnomAD
CA4221845 rs775048159	89	K>R		No	ClinGen ExAC TOPMed gnomAD
CA4221847 rs767958768	90	F>L		No	ClinGen ExAC gnomAD
rs750936533 CA4221848	90	F>S		No	ClinGen ExAC gnomAD
CA4221849 rs756463577	91	V>M		No	ClinGen ExAC gnomAD
CA367278011 rs1412236123	92	S>I		No	ClinGen gnomAD
rs754065932 CA4221851	93	A>T		No	ClinGen ExAC gnomAD
CA367278027 rs1350749422	94	M>I		No	ClinGen TOPMed
CA4221853 rs779128214	97	I>N		No	ClinGen ExAC gnomAD
rs748296186 CA4221854	99	M>I		No	ClinGen ExAC gnomAD
CA367278073 rs1408097796	101	L>F		No	ClinGen gnomAD
CA4221855 rs758564434	102	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4221857 rs746948867	103	F>L		No	ClinGen ExAC TOPMed gnomAD
CA4221858 rs770739044	103	F>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	105	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776331619 CA4221860	106	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs934193947 CA157555022	106	Y>D		No	ClinGen TOPMed gnomAD
CA4221861 rs776331619	106	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs776331619 CA4221859	106	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1436067548 CA367278107	107	V>M		No	ClinGen gnomAD
CA367278124 rs763366923	109	I>M		No	ClinGen gnomAD
TCGA novel	110	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762385575 CA4221864	114	Y>*		No	ClinGen ExAC gnomAD
CA4221863 rs775140156	114	Y>F		No	ClinGen ExAC
rs1331271667 CA367278173	117	F>C		No	ClinGen TOPMed gnomAD
rs773657343 CA4221867	120	C>F		No	ClinGen ExAC gnomAD
CA4221868 rs761132797	122	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1173617666 CA367278207	122	D>N		No	ClinGen gnomAD
CA4221869 rs766731087	123	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1309905555 CA367278227	125	E>*		No	ClinGen gnomAD
rs371125432 CA4221871	127	Y>N		No	ClinGen ExAC gnomAD
rs138253244 CA4221873	129	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1402939826 CA367278267	130	L>P		No	ClinGen TOPMed
rs746935561 CA4221876	131	H>P		No	ClinGen ExAC TOPMed gnomAD
rs778049306 CA4221875	131	H>Y		No	ClinGen ExAC gnomAD
rs143977202 CA4221878	133	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs146912152 CA4221879	134	A>P		No	ClinGen ExAC TOPMed gnomAD
rs769585473 CA4221880	135	A>P		No	ClinGen ExAC gnomAD
CA367278299 rs1269042204	136	S>N		No	ClinGen gnomAD
CA367278300 rs1269042204	136	S>T		No	ClinGen gnomAD
TCGA novel	138	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	138	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4221882 rs775086717	139	M>R		No	ClinGen ExAC TOPMed gnomAD
CA4221883 rs150151168	141	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1583585484 CA367278347	143	V>G		No	ClinGen Ensembl
rs768128761 CA4221884	143	V>M		No	ClinGen ExAC gnomAD
rs988047280 CA157555027	144	I>N		No	ClinGen Ensembl
CA367278350 rs1583585500	144	I>V		No	ClinGen Ensembl
TCGA novel	146	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4221885 rs773770767	146	I>T		No	ClinGen ExAC gnomAD
rs761236497 CA4221886	147	V>L		No	ClinGen ExAC gnomAD
rs761236497 CA367278367	147	V>M		No	ClinGen ExAC gnomAD
CA157555029 rs965201686	148	V>E		No	ClinGen gnomAD
rs1407002835 CA367278378	149	P>L		No	ClinGen gnomAD
CA4221888 rs545002848 COSM70948	149	P>S	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs759751488 CA4221889 COSM3768356	151	V>A	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1230472469 CA367278386	151	V>I		No	ClinGen TOPMed gnomAD
CA367278387 rs1230472469	151	V>L		No	ClinGen TOPMed gnomAD
CA367278402 rs1358038827	153	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA367278404 rs374675345	154	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA4221891 rs374675345	154	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4221890 rs147447409	154	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs751648980 CA4221894	155	Y>*		No	ClinGen ExAC gnomAD
CA4221893 rs764266586	155	Y>C		No	ClinGen ExAC gnomAD
rs1463825410 CA367278419	157	I>V		No	ClinGen TOPMed gnomAD
CA4221895 rs751786639	160	E>*		No	ClinGen ExAC TOPMed gnomAD
CA367278460 rs1249174846	162	N>S		No	ClinGen TOPMed gnomAD
CA4221897 rs780929544	163	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	164	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367278477 rs201057852	164	E>D		No	ClinGen TOPMed gnomAD
CA4221899 rs750408189	165	H>Q		No	ClinGen ExAC gnomAD
CA367278491 rs1386099327	166	C>F		No	ClinGen gnomAD
CA367278489 rs1386099327	166	C>Y		No	ClinGen gnomAD
CA367278495 rs1437029965	167	F>L		No	ClinGen TOPMed gnomAD
TCGA novel	167	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148535598 CA4221901	168	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1048405800 CA157555031	172	E>D		No	ClinGen Ensembl
rs373227698 CA4221902	173	L>F		No	ClinGen ESP ExAC gnomAD
CA4221903 rs768359708	175	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	178	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778469645 CA4221904	180	I>T		No	ClinGen ExAC gnomAD
rs747553664 CA4221905	182	N>I		No	ClinGen ExAC gnomAD
rs747553664 CA367278603	182	N>S		No	ClinGen ExAC gnomAD
rs1554347862 CA4221908	184	M>V		No	ClinGen Ensembl
rs770254655 CA4221911	185	I>T		No	ClinGen ExAC gnomAD
rs760141591 CA4221910	185	I>V		No	ClinGen ExAC gnomAD
CA4221914 rs150636183	186	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4221913 rs763255565	186	V>F		No	ClinGen ExAC gnomAD
rs1459085690 CA367278633	187	I>F		No	ClinGen gnomAD
CA367278636 rs1159593782	187	I>T		No	ClinGen gnomAD
TCGA novel	188	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751814120 CA4221915	190	I>M		No	ClinGen ExAC gnomAD
rs1005996976 CA157555032	190	I>T		No	ClinGen TOPMed gnomAD
CA4221916 rs761762672	191	A>D		No	ClinGen ExAC TOPMed gnomAD
rs61729276 CA157555033	191	A>T		No	ClinGen Ensembl
CA4221917 rs139160883	192	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs750308560 CA4221918	193	A>S		No	ClinGen ExAC gnomAD
CA4221919 rs756081456	193	A>V		No	ClinGen ExAC gnomAD
rs1583585950 CA367278677	195	I>V		No	ClinGen Ensembl
rs144094226 CA4221920	196	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA367278693 rs1208589360	197	L>F		No	ClinGen gnomAD
CA4221922 rs754777360	198	V>D		No	ClinGen ExAC gnomAD
CA4221921 rs753686419	198	V>I		No	ClinGen ExAC gnomAD
rs1204482242 CA367278699	199	F>L		No	ClinGen gnomAD
CA157555035 rs1057377290	199	F>S		No	ClinGen gnomAD
CA4221923 rs778362767	201	V>I		No	ClinGen ExAC gnomAD
CA4221925 rs146529395	204	I>F		No	ClinGen ESP TOPMed
rs146529395 CA4221926	204	I>L		No	ClinGen ESP TOPMed
CA4221927 rs146529395	204	I>V		No	ClinGen ESP TOPMed
CA367278742 rs1562796396	205	M>K		No	ClinGen Ensembl
CA4221930 rs777390147	209	Q>*		No	ClinGen ExAC gnomAD
CA4221932 rs375407880	212	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs375407880 CA367278789	212	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs369757172 CA4221934 COSM1450579	212	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs369757172 CA4221933	212	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4221935 rs769100435	213	H>Q		No	ClinGen ExAC gnomAD
CA367278816 rs1282276615	217	S>A		No	ClinGen TOPMed gnomAD
CA367278817 rs1282276615	217	S>T		No	ClinGen TOPMed gnomAD
rs767461242 CA157555037	219	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA4221938 rs767461242	219	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA367278836 rs1361986821	220	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA367278841 rs1217808086	220	E>V		No	ClinGen gnomAD
COSM2157397 CA367278858 rs1158816682	222	W>*	Variant assessed as Somatic; impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs143169383 CA4221939	223	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367278861 rs1303910982	223	A>T		No	ClinGen gnomAD
rs373247764 CA4221940 COSM746988	224	Q>*	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs145445554 CA157555038	224	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	226	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	227	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA157555040 rs371678132	230	F>V		No	ClinGen Ensembl
rs148854754 CA367278916	231	I>K		No	ClinGen ESP ExAC TOPMed
rs148854754 CA4221944	231	I>T		No	ClinGen ESP ExAC TOPMed
rs761658492	231	I>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246324219 CA367278925	233	V>I		No	ClinGen gnomAD
rs371535293 CA4221945	235	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4221946 rs752268545	236	V>A		No	ClinGen ExAC gnomAD
rs1562796654 CA367278943	236	V>I		No	ClinGen Ensembl
CA4221947 rs758137642	241	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA367278993 rs1166646769	243	F>V		No	ClinGen gnomAD
CA4221949 rs746461138	245	R>G		No	ClinGen ExAC gnomAD
TCGA novel	245	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1322358190 CA367279022	247	Y>D		No	ClinGen gnomAD
CA367279031 rs1347720912	248	Y>S		No	ClinGen gnomAD
CA4221950 rs756832913	250	N>D		No	ClinGen ExAC gnomAD
CA4221953 rs768882527	251	V>A		No	ClinGen ExAC TOPMed gnomAD
CA4221952 rs749839455	251	V>L		No	ClinGen ExAC gnomAD
rs117528446 CA4221954	253	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	255	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1229195209 CA367279083	256	N>S		No	ClinGen gnomAD
TCGA novel	257	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376076843 CA4221956	258	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs376076843 CA367279096	258	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA157555042 rs952828044	260	S>G		No	ClinGen Ensembl
TCGA novel	260	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4221958 rs760678080	262	V>D		No	ClinGen ExAC gnomAD
TCGA novel	264	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM70949 rs766476489 CA4221959	265	Y>C	ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA367279158 rs759565313	267	E>*		No	ClinGen ExAC gnomAD
COSM1089434 CA4221961 rs759565313	267	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA367279167 rs1341857408	268	I>T		No	ClinGen TOPMed
CA4221962 rs190677168	268	I>V		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	270	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382417669 CA367279194	272	V>L		No	ClinGen TOPMed
TCGA novel	273	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4221965 rs752596433	274	A>T		No	ClinGen ExAC gnomAD
CA367279211 rs1411064681	275	I>V		No	ClinGen TOPMed gnomAD
rs1406678518 CA367279219	276	S>C		No	ClinGen gnomAD
CA4221966 rs770851503	276	S>N		No	ClinGen ExAC TOPMed gnomAD
rs778807658 CA4221967	278	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1199887479 CA367279246	279	D>E		No	ClinGen Ensembl
rs1478817081 CA367279280	284	V>A		No	ClinGen TOPMed
TCGA novel	284	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4221969 rs756782086	285	F>C		No	ClinGen ExAC gnomAD
rs780900599 CA4221970	286	G>A		No	ClinGen ExAC gnomAD
CA157555044 rs928646174	288	S>G		No	ClinGen TOPMed gnomAD
rs749784262 CA4221971	288	S>N		No	ClinGen ExAC gnomAD
rs755571982 CA4221972	289	H>R		No	ClinGen ExAC TOPMed gnomAD
rs938639708 CA157555045	289	H>Y		No	ClinGen TOPMed gnomAD
rs1290886369 CA367279341	293	Q>R		No	ClinGen TOPMed gnomAD
rs748484853 CA367279354	295	I>L		No	ClinGen ExAC TOPMed gnomAD
rs748484853 CA4221974	295	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4221975 rs772324619	296	I>T		No	ClinGen ExAC gnomAD
rs1269855834 CA367279370	297	G>V		No	ClinGen gnomAD
rs1220976253 CA367279372	298	L>I		No	ClinGen TOPMed
rs777930630 CA4221976	298	L>S		No	ClinGen ExAC gnomAD
TCGA novel	299	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200611102 CA4221978	300	N>D		No	ClinGen 1000Genomes ExAC gnomAD
rs200611102 CA367279387	300	N>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs776730509 CA4221979	302	V>F		No	ClinGen ExAC
rs76924160 CA4221981	305	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM70950 CA4221983 rs775296772	305	R>H	ovary oesophagus large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4221982 rs775296772	305	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1450584 rs76924160 CA367279421	305	R>S	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with Q7Z602

1 regional properties for Q7Z602

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	33 - 283	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MPGHNTSRNS	SCDPIVTPHL	ISLYFIVLIG	GLVGVISILF	LLVKMNTRSV	TTMAVINLVV
70	80	90	100	110	120
VHSVFLLTVP	FRLTYLIKKT	WMFGLPFCKF	VSAMLHIHMY	LTFLFYVVIL	VTRYLIFFKC
130	140	150	160	170	180
KDKVEFYRKL	HAVAASAGMW	TLVIVIVVPL	VVSRYGIHEE	YNEEHCFKFH	KELAYTYVKI
190	200	210	220	230	240
INYMIVIFVI	AVAVILLVFQ	VFIIMLMVQK	LRHSLLSHQE	FWAQLKNLFF	IGVILVCFLP
250	260	270	280	290	300
YQFFRIYYLN	VVTHSNACNS	KVAFYNEIFL	SVTAISCYDL	LLFVFGGSHW	FKQKIIGLWN

CVLCR