Q7Z5Q1

PR
Gene name
CPEB2
Protein name
Cytoplasmic polyadenylation element-binding protein 2
Names
CPE-BP2, CPE-binding protein 2, hCPEB-2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:132864
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

52-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7Z5Q1

Entry ID Method Resolution Chain Position Source
AF-Q7Z5Q1-F1 Predicted AlphaFoldDB

No variants for Q7Z5Q1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7Z5Q1

No associated diseases with Q7Z5Q1

3 regional properties for Q7Z5Q1

Type Name Position InterPro Accession
domain RNA recognition motif domain 331 - 420 IPR000504-1
domain RNA recognition motif domain 440 - 518 IPR000504-2
domain Cytoplasmic polyadenylation element-binding protein, ZZ domain 513 - 575 IPR032296

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
messenger ribonucleoprotein complex A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

9 GO annotations of molecular function

Name Definition
GTPase inhibitor activity Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
mRNA 3'-UTR AU-rich region binding Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA regulatory element binding translation repressor activity Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
ribosomal large subunit binding Binding to a large ribosomal subunit.
ribosomal small subunit binding Binding to a small ribosomal subunit.
ribosome binding Binding to a ribosome.
RNA binding Binding to an RNA molecule or a portion thereof.
translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.

7 GO annotations of biological process

Name Definition
cellular response to arsenic-containing substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
negative regulation of cytoplasmic translation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.
negative regulation of cytoplasmic translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation.
negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q812E0 Cpeb2 Cytoplasmic polyadenylation element-binding protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPPPSPDSEN GFYPGLPSSM NPAFFPSFSP VSPHGCTGLS VPTSGGGGGG FGGPFSATAV
70 80 90 100 110 120
PPPPPPAMNI PQQQPPPPAA PQQPQSRRSP VSPQLQQQHQ AAAAAFLQQR NSYNHHQPLL
130 140 150 160 170 180
KQSPWSNHQS SGWGTGSMSW GAMHGRDHRR TGNMGIPGTM NQISPLKKPF SGNVIAPPKF
190 200 210 220 230 240
TRSTPSLTPK SWIEDNVFRT DNNSNTLLPL QVRSSLQLPA WGSDSLQDSW CTAAGTSRID
250 260 270 280 290 300
QDRSRMYDSL NMHSLENSLI DIMRAEHDPL KGRLSYPHPG TDNLLMLNGR SSLFPIDDGL
310 320 330 340 350 360
LDDGHSDQVG VLNSPTCYSA HQNGERIERF SRKVFVGGLP PDIDEDEITA SFRRFGPLVV
370 380 390 400 410 420
DWPHKAESKS YFPPKGYAFL LFQEESSVQA LIDACIEEDG KLYLCVSSPT IKDKPVQIRP
430 440 450 460 470 480
WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM DRLYGGVCYA GIDTDPELKY
490 500 510 520 530 540
PKGAGRVAFS NQQSYIAAIS ARFVQLQHGD IDKRVEVKPY VLDDQMCDEC QGARCGGKFA
550 560 570 580
PFFCANVTCL QYYCEFCWAN IHSRAGREFH KPLVKEGADR PRQIHFRWN