AiPD: Autoinhibited Protein Database

Q7Z5D8

Gene name	NANOGNB
Protein name	NANOG neighbor homeobox
Names	Homeobox protein C14
Species	Homo sapiens (Human)
KEGG Pathway	hsa:360030
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-123 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

31-123 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q7Z5D8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7Z5D8-F1	Predicted				AlphaFoldDB

188 variants for Q7Z5D8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA383769930 rs1448697391	2	H>Y		No	ClinGen gnomAD
rs775855759 CA232529466	3	R>G		No	ClinGen ExAC TOPMed gnomAD
rs866678269 CA383769960	3	R>P		No	ClinGen TOPMed gnomAD
rs866678269 CA232529472	3	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs775855759 CA232529468	3	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1004499232 CA232529476	4	A>V		No	ClinGen TOPMed gnomAD
CA232529477 rs747317808	5	R>G		No	ClinGen ExAC TOPMed gnomAD
CA383770002 rs141049797	5	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6429820 rs141049797	5	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383769997 rs141049797	5	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6429819 rs747317808	5	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1193948826 CA383770006	6	W>R		No	ClinGen TOPMed
CA383770048 rs1363620658	8	T>M		No	ClinGen TOPMed gnomAD
CA383770100 rs1298795291	12	P>L		No	ClinGen gnomAD
CA232529491 rs796713985	13	A>E		No	ClinGen TOPMed gnomAD
rs1344595825 CA383770107	13	A>T		No	ClinGen gnomAD
CA232529493 rs796713985	13	A>V		No	ClinGen TOPMed gnomAD
rs1258329211 CA383770126	14	L>F		No	ClinGen TOPMed
TCGA novel	14	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357079068 CA383770148	15	W>*		No	ClinGen TOPMed gnomAD
rs1211690983 CA383770154	15	W>*		No	ClinGen gnomAD
CA383770143 rs1264965838	15	W>R		No	ClinGen gnomAD
CA232529497 rs886214263	16	E>D		No	ClinGen TOPMed
rs1266206139 CA383770173	16	E>G		No	ClinGen TOPMed gnomAD
CA383770198 rs149820722	17	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs149820722 CA6429821	17	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383770213 rs1421693425	18	E>G		No	ClinGen gnomAD
rs1249603000 CA383770203	18	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383770236 rs1368562230	19	A>G		No	ClinGen TOPMed gnomAD
rs12818448 CA6429823	19	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1368562230 CA383770238	19	A>V		No	ClinGen TOPMed gnomAD
rs913303343 CA383770259	21	R>G		No	ClinGen gnomAD
CA383770270 rs1457167753	22	S>T		No	ClinGen gnomAD
CA383770280 rs1367741383	23	R>*		No	ClinGen gnomAD
rs1394528557 CA383770283	23	R>Q		No	ClinGen TOPMed gnomAD
CA383770298 rs1464066389	25	Q>K		No	ClinGen TOPMed
CA383770302 rs1384149279	25	Q>R		No	ClinGen gnomAD
rs1341261705 CA383770330	27	I>F		No	ClinGen gnomAD
CA383770339 rs1247167975	27	I>M		No	ClinGen gnomAD
rs1427988437 CA383770337	27	I>S		No	ClinGen TOPMed
CA383770344 rs1266300920	28	E>*		No	ClinGen TOPMed gnomAD
CA383770341 rs1266300920	28	E>K		No	ClinGen TOPMed gnomAD
rs1478589413 CA383770350	28	E>V		No	ClinGen TOPMed
CA383770360 rs1193354082	29	T>A		No	ClinGen TOPMed
CA383770381 rs1199258327	30	I>M		No	ClinGen TOPMed
CA383770374 rs1209208359	30	I>N		No	ClinGen TOPMed gnomAD
rs1209208359 CA383770379	30	I>S		No	ClinGen TOPMed gnomAD
rs763011633 CA6429825	32	A>S		No	ClinGen ExAC gnomAD
CA383770415 rs1258791968	34	K>Q		No	ClinGen TOPMed
CA383770418 rs1199645570	34	K>T		No	ClinGen gnomAD
CA383770973 rs1183670554	35	K>N		No	ClinGen TOPMed gnomAD
CA232532940 rs1034341755	37	S>T		No	ClinGen TOPMed
CA232532946 rs778968033	38	A>G		No	ClinGen Ensembl
rs1260603097 CA383770998	39	M>I		No	ClinGen gnomAD
rs755627184 CA6429831	40	P>L		No	ClinGen ExAC gnomAD
CA383771006 rs1433479206	41	W>R		No	ClinGen TOPMed
rs1436850930 CA383771044	45	P>L		No	ClinGen TOPMed gnomAD
CA383771046 rs1463684279	46	E>Q		No	ClinGen TOPMed
rs1306356071 CA383771058	47	Q>L		No	ClinGen TOPMed gnomAD
rs1306356071 CA383771057	47	Q>R		No	ClinGen TOPMed gnomAD
CA383771073 rs1435887727	50	G>R		No	ClinGen gnomAD
CA383771080 rs1565471587	51	N>D		No	ClinGen Ensembl
rs1427686963 CA383771103	52	Y>*		No	ClinGen TOPMed
CA383771118 rs1410560373	54	E>K		No	ClinGen gnomAD
CA6429833 rs114136506	58	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1218520248 CA383771199	59	G>E		No	ClinGen gnomAD
rs1592110296 CA383771206	60	K>R		No	ClinGen Ensembl
CA383771272 rs1225869520	63	W>C		No	ClinGen gnomAD
CA383771260 rs1008856218	63	W>G		No	ClinGen TOPMed gnomAD
CA232532982 rs1008856218	63	W>R		No	ClinGen TOPMed gnomAD
CA383771279 rs1249277936	64	R>K		No	ClinGen TOPMed
rs1249277936 CA383771280	64	R>T		No	ClinGen TOPMed
rs1322694842 CA383771320	67	G>*		No	ClinGen TOPMed
rs758922229 CA6429834	69	A>T		No	ClinGen ExAC gnomAD
CA232533013 rs929362242	74	E>K		No	ClinGen Ensembl
CA6429835 rs185000545	75	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383771442 rs1244414463	75	R>Q		No	ClinGen TOPMed gnomAD
rs769053712 CA6429837	76	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1487793811 CA383771449	76	E>K		No	ClinGen gnomAD
CA383771516 rs1167068511	80	K>I		No	ClinGen gnomAD
rs1455893486	81	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6429838 rs774570733	81	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	81	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143895543 CA6429840	82	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1348135869 CA383771573	84	E>A		No	ClinGen gnomAD
CA6429841 rs776296089	85	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs899708417 CA232533065	89	Q>*		No	ClinGen TOPMed gnomAD
rs899708417 CA383771624	89	Q>E		No	ClinGen TOPMed gnomAD
rs1432713702 CA383771685	93	R>K		No	ClinGen gnomAD
CA232533071 rs932491421	93	R>S		No	ClinGen Ensembl
CA6429842 rs763066551	95	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	96	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1365487163 CA383771723	96	E>K		No	ClinGen gnomAD
rs1417091123 CA383771766	98	E>V		No	ClinGen TOPMed
CA383771774 rs1181833946	99	K>E		No	ClinGen TOPMed
rs373676869 CA6429843	102	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA232533086 rs924409705	102	Q>R		No	ClinGen TOPMed
rs1221633120 CA383771827	104	P>L		No	ClinGen gnomAD
rs1320541317 CA383771822	104	P>S		No	ClinGen TOPMed gnomAD
rs1470218122 CA383771832	105	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	106	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759460411 CA6429845	107	R>I		No	ClinGen ExAC gnomAD
rs993148562 CA383771872	107	R>S		No	ClinGen TOPMed
rs767321679 CA6429846	108	L>*		No	ClinGen ExAC TOPMed gnomAD
rs917955933 CA232533124	108	L>F		No	ClinGen TOPMed
CA232533128 rs1053589945	109	V>I		No	ClinGen Ensembl
rs948031139 CA232533129	112	S>C		No	ClinGen TOPMed
CA6429847 rs752332013	115	H>R		No	ClinGen ExAC gnomAD
rs749994978 CA6429848	116	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1165562657 CA383772014	118	W>*		No	ClinGen gnomAD
CA6429849 rs763596163	118	W>R		No	ClinGen ExAC gnomAD
CA383772026 rs1396670870	119	A>E		No	ClinGen gnomAD
CA383772030 rs1396670870	119	A>G		No	ClinGen gnomAD
CA383772061 rs1455520176	121	F>Y		No	ClinGen gnomAD
rs1216201382 CA383772073	122	K>R		No	ClinGen gnomAD
rs1389050325 CA383772108	124	N>K		No	ClinGen gnomAD
CA232533147 rs1045049151	124	N>S		No	ClinGen TOPMed gnomAD
rs1459694844 CA383772115	125	R>K		No	ClinGen TOPMed
rs1159073365 CA383772131	126	C>Y		No	ClinGen TOPMed
CA383772145 rs1282118809	127	P>S		No	ClinGen gnomAD
CA232533151 rs893631836	128	T>I		No	ClinGen TOPMed
CA383772174 rs1294583298	129	I>M		No	ClinGen gnomAD
rs1228464836 CA383772165	129	I>V		No	ClinGen gnomAD
rs1337603031 CA383772177	130	Q>*		No	ClinGen TOPMed gnomAD
rs1337603031 CA383772178	130	Q>E		No	ClinGen TOPMed gnomAD
rs1207316556 CA383772183	130	Q>P		No	ClinGen gnomAD
rs1009345618 CA232533155	132	S>N		No	ClinGen TOPMed
CA383772241 rs1447982666	134	S>A		No	ClinGen TOPMed gnomAD
CA383772237 rs1447982666	134	S>T		No	ClinGen TOPMed gnomAD
rs906235511 CA232533160	137	F>S		No	ClinGen TOPMed
rs756756506 CA6429851	139	F>V		No	ClinGen ExAC TOPMed gnomAD
CA383772323 rs1301512948	140	D>G		No	ClinGen TOPMed
CA383772315 rs1453256049	140	D>N		No	ClinGen TOPMed gnomAD
CA383772342 rs1565471700	141	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA383772332 rs1420028097	141	M>L		No	ClinGen gnomAD
rs1420028097 CA383772330	141	M>V		No	ClinGen gnomAD
CA383772354 rs1471587269	142	T>K		No	ClinGen gnomAD
CA383772367 rs1421305006	143	H>R		No	ClinGen TOPMed gnomAD
rs1393420217 CA383772361	143	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1033935847 CA232533197	144	K>Q		No	ClinGen TOPMed gnomAD
CA232533201 rs959864912	145	Q>H		No	ClinGen Ensembl
CA6429857 rs748408334	146	I>L		No	ClinGen ExAC TOPMed gnomAD
rs748408334 CA6429856	146	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1471113052 CA383772732	147	S>R		No	ClinGen gnomAD
rs1170611480 CA383772744	148	Q>H		No	ClinGen gnomAD
rs1424127864 CA383772755	150	F>I		No	ClinGen gnomAD
rs1435307624 CA383772767	151	C>S		No	ClinGen TOPMed
CA383772772 rs1376715336	152	K>E		No	ClinGen TOPMed
CA232533277 rs77290736	153	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6429858 COSM943676 rs77290736	153	T>M	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs968445530 CA232533269	153	T>P		No	ClinGen TOPMed gnomAD
CA383772809 rs1336880724	157	Y>C		No	ClinGen gnomAD
CA232533305 rs548793247	158	N>D		No	ClinGen 1000Genomes gnomAD
rs1273473394 CA383772819	158	N>S		No	ClinGen gnomAD
CA383772828 rs1344691464	159	K>E		No	ClinGen gnomAD
rs1486969213 CA383772845	160	E>*		No	ClinGen TOPMed
rs1340297913 CA383772866	161	M>I		No	ClinGen gnomAD
rs992784929 CA232533323	161	M>T		No	ClinGen TOPMed
CA383772859 rs1282785980	161	M>V		No	ClinGen gnomAD
rs1439498615 CA383772896 COSM943677	163	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1251265431 CA383772885	163	K>Q		No	ClinGen gnomAD
rs1196616546 CA383772900	164	R>G		No	ClinGen gnomAD
CA232533334 rs932585824	164	R>K		No	ClinGen Ensembl
CA383772935 rs1308232216	166	H>R		No	ClinGen TOPMed
rs1275362113 CA383772965	168	K>R		No	ClinGen TOPMed
CA232533336 rs376922335	169	K>N		No	ClinGen Ensembl
CA6429861 rs774477338	170	H>R		No	ClinGen ExAC TOPMed gnomAD
CA383773029 rs1454576237	172	R>I		No	ClinGen gnomAD
CA232536110 rs1000835827	173	W>R		No	ClinGen TOPMed gnomAD
TCGA novel	174	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195276652 CA383773767	175	S>A		No	ClinGen TOPMed gnomAD
CA383773865 rs1350012375	179	Q>*		No	ClinGen TOPMed
rs1033363486 CA232536127	179	Q>R		No	ClinGen Ensembl
rs955955665 CA232536132	180	G>D		No	ClinGen Ensembl
rs955955665 CA383773889	180	G>V		No	ClinGen Ensembl
rs1448531706 CA383773915	181	W>*		No	ClinGen TOPMed gnomAD
rs1448531706 CA383773924	181	W>C		No	ClinGen TOPMed gnomAD
rs1592111454 CA383773930	182	S>A		No	ClinGen Ensembl
rs184126538 CA6429875	183	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6429876 rs538087276	183	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA383773958 rs1592111465	184	T>P		No	ClinGen Ensembl
TCGA novel	185	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383773991 rs1408625352	185	P>L		No	ClinGen TOPMed
rs1024117210 CA232536152	186	A>V		No	ClinGen Ensembl
CA383774012 rs1160291210	187	L>F		No	ClinGen TOPMed
CA383774019 rs1468109251	187	L>P		No	ClinGen TOPMed
CA383774058 rs1471546293	189	K>L		No	ClinGen TOPMed gnomAD
rs1471546293 CA383774047	189	K>S		No	ClinGen TOPMed gnomAD

No associated diseases with Q7Z5D8

1 regional properties for Q7Z5D8

Type	Name	Position	InterPro Accession
domain	Homeobox domain	100 - 160	IPR001356

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MHRARWLTPV	IPALWEAEAG	RSRGQEIETI	LANKKQSAMP	WDQDPEQSTG	NYSEDEQNGK
70	80	90	100	110	120
QKWREEGEAG	RKREREKEEK	NEKELQDEQE	NKRKRENEKQ	KQYPEKRLVS	KSLMHTLWAK
130	140	150	160	170	180
FKLNRCPTIQ	ESLSLSFEFD	MTHKQISQWF	CKTRKKYNKE	MSKRKHKKKH	MRWRSLCCQG

WSRTPALK