Q7YXU4

PR
Gene name
cpnA (DDB_G0293008)
Protein name
Copine-A
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0293008
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7YXU4

Entry ID Method Resolution Chain Position Source
AF-Q7YXU4-F1 Predicted AlphaFoldDB

No variants for Q7YXU4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7YXU4

No associated diseases with Q7YXU4

5 regional properties for Q7YXU4

Type Name Position InterPro Accession
domain C2 domain 1 - 111 IPR000008-1
domain C2 domain 116 - 246 IPR000008-2
domain von Willebrand factor, type A 284 - 484 IPR002035
domain Copine, C-terminal 305 - 518 IPR010734
domain Copine, C2B domain 136 - 246 IPR037768

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
  • In starved cells it binds transiently and in a calcium-dependent manner to the plasma membrane and intracellular vacuoles
  • In some cells, the transient membrane localization is observed to occur multiple times in an oscillatory manner over several minutes
  • Also found to be associated to the plasma membrane, contractile vacuoles, organelles of the endolysosomal pathway and phagosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
contractile vacuolar membrane The lipid bilayer surrounding the contractile vacuole.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane The lipid bilayer surrounding an early endosome.
late endosome membrane The lipid bilayer surrounding a late endosome.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
metal ion binding Binding to a metal ion.

15 GO annotations of biological process

Name Definition
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
contractile vacuole discharge The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane.
contractile vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores.
culmination involved in sorocarp development The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.
hypotonic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
negative regulation of exocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
positive phototaxis The directed movement of a cell or organism towards a source of light.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of aggregate size involved in sorocarp development Any process that modulates the size of the aggregate formed during sorocarp formation.
regulation of post-lysosomal vacuole size Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.
response to ammonium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.
response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
sorocarp stalk cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum.
thermotaxis The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLKPPTSKV ELRIKCHKIL DKDTLSKSDP RASVYEKDRA GQFRLIGKTE TIQNQLNPEF
70 80 90 100 110 120
KTPIVIDYRF EEIQVLKFEI HDVDKNDEDF IGDASCTLTS ILSKPGQTVC LQLLTKSGKH
130 140 150 160 170 180
AGSMTVIAEE IKNTLQTIKF NLIGKKFDKK DLFGAGCDPY LIISRKVPST NTFVKIYESQ
190 200 210 220 230 240
VQKGTLNPVF SGIEMKLEEL CGGDMQREIK FEFYDWDRIG KHDYIGEFHT NAQELLQPNQ
250 260 270 280 290 300
AFNVINSHKQ EKKSGYKNSG TVSVSDAVIE REYNFLEYIM GGCQMNLIVG IDCTASNGDS
310 320 330 340 350 360
NDPNSLHYKN AQGLNQYANA ICSVGNVIVP YTTTPLIPVY GFGGIMPGQS EVSHCFPMTL
370 380 390 400 410 420
NASNTLCCGV NGVLDCYYDN ISKIQLHGPT YFAPLINMAA RYASQGQSQS NQKYTILMII
430 440 450 460 470 480
TDGEILDADN TIDAIVKSSG LPLSIIIVGV GNANFTNMNI LDGDDAALQS GGVRAERDIV
490 500 510 520 530 540
QFVAMRDYLN RPNELAAEVL REIPTQFLSF MKKYKFRPNP PPPPPPVIIG APPQYDNPTT
550 560 570 580 590
TTTATSPSTG IDLNKGSNVG LNLTKTESSP SPSGGAGIDL NKGSVVDITK GVSNVSLEKN